Format:
Online-Ressource
ISSN:
1099-0690
Content:
Abstract: The semi‐synthesis of melithiazol C (2b) has been accomplished in 4 steps and 41% overall yield starting from myxothiazol A (1a) produced by fermentation of Myxococcus fulvus. Key steps are a novel reductive cleavage of a thiazole ring by DIBAL‐H and the conversion of the amide 2a into the methyl ester 2b via an imino ester. The biological activities of 2b and of derivatives of its 10‐acetyl group are described.
In:
volume:2000
In:
number:11
In:
year:2000
In:
pages:2021-2026
In:
extent:6
In:
European journal of organic chemistry, Weinheim : Wiley-VCH Verl., 1998-, 2000, Heft 11 (2000), 2021-2026 (gesamt 6), 1099-0690
Language:
English
DOI:
10.1002/1099-0690(200006)2000:11〈2021::AID-EJOC2021〉3.0.CO;2-K
URN:
urn:nbn:de:101:1-2023110305310382282172
URL:
https://doi.org/10.1002/1099-0690(200006)2000:11〈2021::AID-EJOC2021〉3.0.CO;2-K
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023110305310382282172
URL:
https://d-nb.info/1308428480/34
URL:
https://doi.org/10.1002/1099-0690(200006)2000:11〈2021::AID-EJOC2021〉3.0.CO;2-K
Bookmarklink