ISSN:
2225-4110
Content:
The anticonvulsant potential of Ficus carica methanol-extract (Fc) has been studied. It was found that Fc most active fraction is rich in oligosaccharides (OFG). 1H, 13C NMR and Nano-ESI, MALDI MS, and LC-MS techniques proved that OFG contains alpha-glucopyranoside oligomer in high amounts. Both Fc and OFG reduced strychnine (STR) convulsion-action. Fc and OFG fully protected the experimental-animals from STR-lethality. The intracerebroventricular-administration (ICV) of Fc or OFG in combination with glycine in ethanol-treated mice caused a dose-dependent returning to a 2nd-loss of righting-reflex (LORR), and was antagonized by STR. FC and OFG ICV injection counteracted STR-inhibition, confirming that Fc/OFG anticonvulsant mechanism of action was mediated by potentiation of glycine receptor. These results support Fc and OFG potential anticonvulsant-activity with good safety-profile. Keywords: Ficus carica, Moraceae, Nano-ESI MS, MALDI MS, Intracerebroventricular, Anticonvulsant activity.
In:
Journal of traditional and complementary medicine, Mumbai : Medknow Publ., 2011-, Band 9, Heft 4 (2018), Seite 263-270, 2225-4110
In:
volume:9
In:
year:2018
In:
number:4
In:
pages:263-270
In:
extent:8
Language:
English
DOI:
10.1016/j.jtcme.2018.01.007
URN:
urn:nbn:de:hebis:30:3-544961
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