Format:
1 online resource (353 pages)
Edition:
1st ed.
ISBN:
9783642273407
Series Statement:
Current Topics in Microbiology and Immunology Ser. v.369
Content:
Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted.
Content:
Intro -- Hepatitis C Virus: From Molecular Virology to Antiviral Therapy -- Preface -- Contents -- The Origin of Hepatitis C Virus -- 1 HCV Genetic Diversity and Genotype Classification -- 2 The Recent Spread of HCV -- 3 Endemic Circulation of HCV -- 4 Origins of Human Infections and HCV Homologues in Other Mammals -- 5 Concluding Thoughts -- References -- Cell Culture Systems for Hepatitis C Virus -- Abbreviations -- 1 Introduction -- 2 HCV Replicon System -- 2.1 Replication Enhancing Mutations -- 3 Retroviral Pseudoparticles -- 3.1 Other Models to Study Individual Steps of HCV Cell Entry -- 4 Cell Culture Infectious HCV Genomes and Host Cells -- 4.1 JFH1 and Chimeric Genomes -- 4.2 Adaptation of Infectious HCV Genomes to Cell Culture -- 4.3 HCV Trans-Complemented Particles -- 4.4 Permissive Host Cells -- 5 HCV Replication Models in Primary Cells and Patient Isolates -- 6 Future Perspectives and Conclusions -- References -- Animal Models for Hepatitis C -- Abstract -- Abbreviations -- 1 Introduction -- 2 Non-human Primate Models for Hepatitis C -- 2.1 Chimpanzees -- 2.2 Constraints of Other Non-human Primate Models -- 3 Tree Shrews -- 4 HCV Orthologs -- 4.1 GB Virus B -- 4.2 Canine/Non-primate Hepaciviruses -- 5 Rodent Models -- 5.1 Transgenic Animals for the Study of Hepatitis C -- 5.2 Toward a Genetically Humanized Mouse Model for HCV Infection -- 5.3 Expanding the Host Range of HCV by Viral Adaptation -- 5.4 Xenotransplantation Models -- 5.4.1 Hepatoma Transplantation Models -- 5.4.2 Ectopic Liver Implant Models -- 5.4.3 Human Liver Chimeric Mice -- Urokinase Plasminogen Activator Transgenic Mice -- Fumaryl Acetoacetate Hydrolase Deficiency -- Other Liver Injury Models for Human Xenotransplantation -- 5.4.4 Toward a Xenotransplantation Model for the Study of HCV Pathogenesis and Immunity.
Note:
Description based on publisher supplied metadata and other sources
Additional Edition:
9783642429361
Additional Edition:
Erscheint auch als Druck-Ausgabe 9783642429361
Language:
English
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