Format:
Online-Ressource
ISSN:
1421-9786
Content:
Introduction: Poststroke apathy (PSA) is a common neuropsychiatric disorder that may affect up to 30% of stroke patients. Despite the difficulties of investigating this condition (overlapping with depression, heterogeneity of diagnostic criteria, a small number of studies), some recent diffusion tensor imaging studies have suggested that widespread microstructural white matter (WM) disruption plays a key role in the development of PSA. Therefore, we intended to investigate this hypothesis by evaluating the relationship between WM hyperintensities (WMH) and apathy in patients with cerebrovascular disease. Methods: We studied patients with apathy (n = 7), depression (n = 13), comorbid apathy and depression (n = 13), and controls (n = 20), and we investigated the variables associated with the volume of WMH measured by an automated brain MRI segmentation software. Results: The overall prevalence of PSA was 37.7% (pure and comorbid). Patients with apathy presented a higher volume of WMH in comparison to controls. Mini-Mental State Examination (MMSE), NPI-A, and the number of cerebral microbleeds were the only variables associated with WMH. Conversely, NPI-D did not correlate to WMH. Discussion/Conclusion: This is an exploratory study that supports the view of PSA as a distinct syndrome from PSD mediated mainly by diffuse white matter hyperintensities, which suggests that WM disruption is an important pathway to the development of apathy in stroke patients.
In:
volume:52
In:
number:4
In:
year:2023
In:
pages:435-441
In:
extent:7
In:
Cerebrovascular diseases, Basel : Karger, 1991-, 52, Heft 4 (2023), 435-441 (gesamt 7), 1421-9786
Language:
English
URN:
urn:nbn:de:101:1-2023091400143203271865
URL:
https://doi.org/10.1159/000526939
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023091400143203271865
URL:
https://d-nb.info/1302454412/34
URL:
https://karger.com/ced/article-pdf/52/4/435/3994981/000526939.pdf
URL:
https://karger.com/doi/10.1159/000526939
Bookmarklink