Format:
Online-Ressource
ISSN:
1521-4141
Content:
Abstract: The natural killer cell gene complex on human chromosome 12p12‐13 encodes several C‐type lectin receptor genes expressed by NK cells and other hematopoietic cells. We have identified a novel receptor gene in this region encoding a putative type II transmembrane glycoprotein. The product is 54 % identical to the rat mast cell function‐associated antigen (MAFA), which inhibits mast cell activation by IgE. The human MAFA‐like receptor (MAFA‐L) and the rat MAFA protein are expressed by basophils and both have an immunoreceptor tyrosine‐based inhibitory motif in the cytoplasmic tail, consistent with an inhibitory role in basophil activation. Unlike rat MAFA, expression of the MAFA‐L gene is not limited to mast cells and basophils. In common with other genes in the NK cell gene complex MAFA‐L is also expressed by natural killer cells as well as the monocyte‐like cell‐line U937. Expression in NK cells is restricted to peripheral blood NK cells, decidual NK cells do not express MAFA‐L. While MAFA‐L and rat MAFA might have a similar role in basophils, the expression of MAFA‐L in other cell types implies additional functions for this molecule. The presence of the MAFA‐L gene in the human NK cell complex indicates that this locus encodes C‐type lectin receptors expressed by a variety of cells important in host defense.
In:
volume:28
In:
number:11
In:
year:1998
In:
pages:3755-3762
In:
extent:8
In:
European journal of immunology, Weinheim : Wiley-VCH, 1971-, 28, Heft 11 (1998), 3755-3762 (gesamt 8), 1521-4141
Language:
English
DOI:
10.1002/(SICI)1521-4141(199811)28:11〈3755::AID-IMMU3755〉3.0.CO;2-3
URN:
urn:nbn:de:101:1-2023120704301505407145
URL:
https://doi.org/10.1002/(SICI)1521-4141(199811)28:11〈3755::AID-IMMU3755〉3.0.CO;2-3
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023120704301505407145
URL:
https://d-nb.info/1312439785/34
URL:
https://doi.org/10.1002/(SICI)1521-4141(199811)28:11〈3755::AID-IMMU3755〉3.0.CO;2-3
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