Kooperativer Bibliotheksverbund

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Format: Online-Ressource , v.: digital

Edition: Online-Ausg. 2005 Springer eBook Collection. Medicine Electronic reproduction; Available via World Wide Web

ISBN: 9781592598519

Series Statement: Cancer Drug Discovery and Development

Content: An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.

Note: Includes bibliographical references and index , Mammalian cell death pathways: intrinsic and extrinsicResistance to apoptosis in cancer therapy -- Structures of TNF receptors and their interactions with ligands -- Death receptor signaling in embryonic ectodermal development -- Adaptor proteins in death receptor signalin -- Caspase activation by the extrinsic pathway -- Death signaling and therapeutic applications of TRAIL -- Death receptor mutations -- Regulation of death receptors -- Regulation of trail receptor expression in human melanoma -- Regulation of death receptors by synthetic retinoids -- Role of p53 in regulation of death receptors -- Proapoptotic gene silencing via methylation in human tumors -- Regulation of death receptor-induced apoptosis by NF-kB and interferon signaling pathways: implications for cancer therapy -- TRAIL in cancer therapy -- Expression and regulation of death receptors in multiple myeloma and prostate carcinoma -- Regulation of TRAIL-induced apoptosis by transcriptional factors -- Sensitizing tumor cells by targeting death receptor signaling inhibitors -- Ceramide, ceramidase, and FasL gene therapy in prostate cancer -- Gene therapy targeting receptor-mediated cell death the cancer -- Combination of chemotherapy and death ligands in cancer therapy. , Electronic reproduction; Available via World Wide Web

Additional Edition: 9781588291721

Additional Edition: Print version Death Receptors in Cancer Therapy

Language: English

Subjects: Medicine

Keywords: Krebs ; Apoptosis

DOI: 10.1385/159259851X

URL: Volltext  (lizenzpflichtig)

URL: Volltext

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Format: VIII, 446 S. : Ill. , 24 cm

ISBN: 9781461461753

Series Statement: Advances in experimental medicine and biology 779

Additional Edition: Erscheint auch als Online-Ausgabe 9781461461760

Language: English

URL: Inhaltsverzeichnis

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Format: VIII, 446 p. 22 illus., 21 illus. in color

ISBN: 9781461461760

Series Statement: Advances in Experimental Medicine and Biology 779

Additional Edition: Erscheint auch als Druck-Ausgabe 9781461461753

Language: English

DOI: 10.1007/978-1-4614-6176-0

URL: http://dx.doi.org/10.1007/978-1-4614-6176-0

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Format: XIX, 657 S. , Ill., graph. Darst. , 26 cm

ISBN: 0896039870 , 1592593291

Series Statement: Tumor suppressor genes Vol. 2

Note: Literaturangaben

Language: English

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Format: XIX, 504 S. , Ill., graph. Darst.

ISBN: 0896039862 , 1592593283

Series Statement: Methods in molecular biology 222

Note: e-book: 1-59259-328-3

In: 1

Language: English

Keywords: Tumorsuppressor-Gen ; Labortechnik

URL: Inhaltsverzeichnis

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Format: XIX, 657 S. , Ill., graph. Darst.

ISBN: 0896039870 , 1592593283

Series Statement: Methods in molecular biology 223

Note: e-book: 1-59259-328-3

In: 2

Language: English

Keywords: Tumorsuppressor-Gen ; Labortechnik

URL: Inhaltsverzeichnis

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Format: Online-Ressource (VIII, 446 p. 22 illus., 21 illus. in color, digital)

ISBN: 9781461461760 , 1283945894 , 9781283945899

Series Statement: Advances in Experimental Medicine and Biology 779

Content: ​​​The topic of ‘Impact of genetic targets on cancer therapy’ has reviews that each focuses on a specific tumor type, review recent knowledge about molecular pathogenesis in general and especially as it impacts response to therapy. The topic is aimed to provide a forum for publication of original peer-reviewed short communications, full-length research and review articles on new research findings and developments in cancer therapies. As the field is highly important it requires co-operation between research communities from all over the world to share their knowledge and experience in order to build a comprehensive knowledge on genetic targets on different cancer therapies. Each chapter also includes a discussion of the impact of the tumor microenvironment and cancer stem cells and cover current knowledge in this area as it pertains to the disease, including emerging therapy targeting the microenvironment and/or cancer stem cells

Note: Description based upon print version of record , Impact of Genetic Targetson Cancer Therapy; Forward; Contents; Novel Antineoplastics Targeting Genetic Changes in Colorectal Cancer; Introduction; Overview of Genetic Alterations in Colorectal Cancer; Targeting Cell Death Pathways; Agonistic TRAIL Death Receptor Antibodies; Bcl-2; Targeting Growth Factor Signaling; The EGFR Family; IGF Receptors; Hepatocyte Growth Factor (HGF); Mutant BRAF; MEK; Akt; Mammalian Target of Rapamycin (mTOR); Protein Kinase C (PKC); Targeting Angiogenesis; VEGF Receptors; Other Receptors That Mediate Angiogenesis; Multi-Targeted Agents; Sorafenib; Sunitinib , DasatinibHarnessing the Immune System; Epithelial Cell Adhesion Molecule (EpCAM); Toll-Like Receptor 9 (TLR9); A33; Other Approaches; Wnt and Hedgehog Signaling Pathways; COX-2; Heat Shock Protein 90 (Hsp90); Virotherapy; Colorectal Cancer Stem Cells (CRCSCs); Stem Cell Signaling in CRC; Stem Cell Microenvironment in CRC; References; Update on Clinical Trials: Genetic Targets in Breast Cancer; Cell Membrane Signaling; Growth Factor Receptors EGFR and HER2- neu as Molecular Targets in Breast Cancer; IGF in Breast Cancer; Impact of the Tumor Microenvironment and Cancer Stem Cells , Cancer Stem Cells and Stem Cell Niche in Breast CancerAngiogenic Targets; Intracellular Signaling and Genetic, Epigenetic Targets; Intracellular Signaling; Ras, Raf, mTOR; Post-Translational Modi fi cation: Histone Deacytelase Inhibitors (HDACIs); MicroRNAs and the Molecular Pathogenesis of Breast Cancer; Telomerase Inhibitors in Breast Cancer; PARP in Breast Cancer; Hormone Receptor Positive but Resistant to Hormone Therapy; Mechanisms of Hormone Resistance; Conclusion; References; Impact of Genetic Targets on Cancer Therapy in Esophagogastric Cancer; Introduction , Targeting Epidermal Growth Factor Receptor (EGFR) Family PathwayTargeting Angiogenesis Pathway; Other Potential Targets; Conclusions; References; Impact of Genetic Targets on Cancer Therapy: Hepatocellular Cancer; Introduction; Pathogenesis and Genetics for HCC; Hepatitis Virus Infections and HCC; Sorafenib and Targeted Therapy for HCC; Types of Targeted Therapies; Tyrosine Kinase Inhibitors TKIs; Monoclonal Antibodies (mABs); Enzyme Inhibitors; Miscellaneous Agents; Combination Therapy and Future Directions; Cancer Stem Cells and New Targets in HCC; Conclusion; References , Toward the Goal of Personalized Therapy in Pancreatic Cancer by Targeting the Molecular PhenotypeIntroduction; Genetic Alterations Involved in Pathogenesis of Pancreatic Adenocarcinoma; Genetic Alterations as Therapeutic Targets; Receptor Tyrosine Kinases and Ligands; Epidermal Growth Factor (EGF); Insulin-Like Growth Factor-1 (IGF-1); Hepatocyte Growth Factor (HGF); Signal Transducers; RAS; MEK; AKT; Mammalian Target of Rapamycin (mTOR); Heat Shock Protein (Hsp90); Nuclear Targets; Histone Deacetylases (HDACs); Polo-Like Kinase 1 (Plk1); Ribonucleotide Reductase (RR) , Peroxisome Proliferator-Activated Receptor g (PPAR g) , ​​​Novel antineoplastics targeting genetic changes in colorectal cancer -- Update on Clinical Trials: Genetic Targets in Breast Cancer -- Impact of Genetic Targets on Cancer Therapy in Esophagogastric Cancer -- Impact of Genetic Targets on Cancer Therapy: Liver Cancer -- Targeting the molecular phenotype of pancreatic cancer toward the goal of patient-tailored therapy -- Impact of genetic markers on treatment of Non-small cell lung cancer -- Impact of Genetic Targets on Therapy in Head and Neck Squamous Cell Carcinoma -- Tyrosine Kinase Targeted Treatment of Chronic Myelogenous Leukemia and Other Myeloproliferative Neoplasms -- Targeted Therapy of Multiple Myeloma -- Current and Future Trials of Targeted Therapies in Cutaneous Melanoma -- Current Approaches to Epigenetic therapy for the treatment of Mantle Cell Lymphoma -- Impact of Genetic Targets on Primary Brain Tumor Therapy: What’s Ready for Prime Time? -- Rational therapy for renal cell carcinoma based on its genetic targets -- Molecular and Genetic Markers of Follicular-Cell Thyroid Cancer: Etiology and Diagnostic and Therapeutic Opportunities -- Genetic Targets in Pediatric Acute Lymphoblastic Leukemia -- Emerging molecular therapies for the treatment of Acute Lymphoblastic Leukemia -- Impact of Genetic Targets on Prostate Cancer Therapy -- Small-Cell Lung Cancer: An Update on Targeted Therapies -- Impact of Genetic Targets on Cancer Therapy in Acute Myelogenous Leukemia -- Index.

Additional Edition: ISBN 9781461461753

Additional Edition: Buchausg. u.d.T. ISBN 978-1-461-46175-3

Language: English

DOI: 10.1007/978-1-4614-6176-0

URL: Volltext

URL: Volltext  (lizenzpflichtig)

URL: Cover

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Format: XIX, 657 S.

ISBN: 1592593291

Series Statement: Tumor suppressor genes / ed. by Wafik S. El-Deiry 2

Language: English

Keywords: Aufsatzsammlung

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Format: XI, 374 p. , ill. , 26 cm

Series Statement: Cancer drug discovery and development

Note: Includes bibliographical references and index

Language: English

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Series Statement: Methods in molecular biology ...

Language: English

Keywords: Aufsatzsammlung