Format:
Online-Ressource
ISSN:
1521-4184
Content:
A set of 6‐substituted quinolone nucleosides linked to aniline or phenol via N or O heteroatom‐bridges presenting new compounds were synthesized by palladium‐catalyzed Buchwald–Hartwig cross‐coupling reactions. 6‐Bromoquinolone nucleoside precursors, being protected by either benzoyl or TBDMS protecting groups on the ribose moiety, were subjected to different Buchwald–Hartwig conditions as the key step. Defined deprotection steps led, in good yields, to the final target compounds that carry, in position 3, either ester, acid, or amide functions. Thus, a series of novel quinolone nucleoside derivatives was obtained via a convergent synthesis route. Biological tests in human chronic myelogenous leukemia K562 cells exerted an efficient antiproliferative activity for two of them without induction of differentiation. These novel nucleosides deserve further experiments to determine their antiproliferative effects on other CML cell lines.
In:
volume:346
In:
number:10
In:
year:2013
In:
pages:757-765
In:
extent:9
In:
Archiv der Pharmazie, Weinheim : Wiley-VCH, 1822-, 346, Heft 10 (2013), 757-765 (gesamt 9), 1521-4184
Language:
English
DOI:
10.1002/ardp.201300232
URN:
urn:nbn:de:101:1-2023020507303657603328
URL:
https://doi.org/10.1002/ardp.201300232
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023020507303657603328
URL:
https://d-nb.info/1280108134/34
URL:
https://doi.org/10.1002/ardp.201300232
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