Format:
Online-Ressource
ISSN:
1521-4184
Content:
Abstract: Synthesis of 2‐chloro‐1,1‐dimethylethyl and 2‐chloro‐2,2‐dimethylethyl analogues of ifosfamide was performed via aziridine intermediate. In vitro metabolic activation showed that both compounds are metabolised at a rate similar to the parent drug. However, their anticancer activity against L1210 leukaemia in mice was lower as compared with ifosfamide. The reduction of antitumour efficiency of examined analogues is probably caused by a lower ability to cross‐link DNA by their final, active metabolites.
In:
volume:334
In:
number:8‐9
In:
year:2001
In:
pages:291-294
In:
extent:4
In:
Archiv der Pharmazie, Weinheim : Wiley-VCH, 1822-, 334, Heft 8‐9 (2001), 291-294 (gesamt 4), 1521-4184
Language:
English
DOI:
10.1002/1521-4184(200109)334:8/9〈291::AID-ARDP291〉3.0.CO;2-J
URN:
urn:nbn:de:101:1-2023111204285022602197
URL:
https://doi.org/10.1002/1521-4184(200109)334:8/9〈291::AID-ARDP291〉3.0.CO;2-J
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023111204285022602197
URL:
https://d-nb.info/1309531013/34
URL:
https://doi.org/10.1002/1521-4184(200109)334:8/9〈291::AID-ARDP291〉3.0.CO;2-J
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