Format:
1 Online-Ressource (475 Seiten)
ISBN:
9781000462944
Content:
Cover -- Half Title -- Title -- Copyright -- Contents -- Foreword -- Acknowledgments -- Author -- Introduction -- 1. Structure-Activity Relationships (SAR) -- 1.1 Undergraduate Academic Training (1961-1966), School of Pharmacy, Central University of Venezuela -- 1.2 Graduate Studies in Medicinal Chemistry (1966-1970) at the University of Michigan, Ann Arbor, Michigan -- 1.2.1 Antimalarial Agents -- 1.2.2 The Mechanism of Action of Amodiaquine -- 1.2.3 The Mechanism of Action of Chloroquine -- 1.3 Biogenic 4-Hydroxytryptamines: Approaches to the Synthesis of Baeocystin -- 1.4 Conclusions -- 2. Brain Antitumor Agents: The Story of Spiromustin -- 2.1 Postdoctoral Fellowship (September 1970-September 1971) at the Drug Development Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, Maryland -- 2.2 Central Nervous System Antitumor Agents, Nitrogen Mustards, and the Concept of Partition Coefficient -- 2.3 Exploring New Chemistry -- 2.4 Conclusions -- 3. Privileged Drug Scaffolds: The Story of LC-6 and Pyridinolcarbamate -- 3.1 Research Director, Laboratorios Cosmos, S. A., Caracas, Venezuela (January 1972-April 1977) -- 3.2 Head of a Mouse or Tail of a Lion -- 3.3 Where to Start? -- 3.4 Nitrogen-Containing Steroidal Analogues (Aza-Steroids) -- 3.5 The Biological Activity of LC-6 -- 3.6 Pyridinol Carbamate Analogues -- 3.7 Additional Studies -- 3.8 Conclusions -- 4. Cytidine Deaminase: Part 1-The Concept of Transition-State Inhibitors and the Discovery of Zebularine -- 4.1 Laboratory of Pharmacology and Experimental Therapeutics, Medicinal Chemistry Section, National Cancer Institute, Bethesda, Maryland -- 4.2 A Brief Primer on Nucleosides and Nucleotides -- 4.3 Transition-State Inhibitors and Cytidine Deaminase -- 4.4 Tetrahydrouridine (THU) -- 4.5 Zebularine -- 4.6 Proof of Concept.
Note:
Description based on publisher supplied metadata and other sources
Additional Edition:
9781032067100
Additional Edition:
9781032063638
Additional Edition:
Erscheint auch als Druck-Ausgabe 9781032067100
Language:
English
DOI:
10.1201/9781003203506
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