Format:
1 Online-Ressource (281 pages)
ISBN:
9783319550213
Series Statement:
Epigenetics and Human Health
Content:
Preface -- Contents -- Chapter 1: DNA Methylation of Human Papillomavirus Genomes During Infection and Cancer Progression -- 1.1 Introduction -- 1.2 History of Papillomavirus Methylation Research -- 1.3 Methylation of HPV DNA During the Normal Life Cycle -- 1.3.1 In Summary -- 1.4 Regulatory Effects of DNA Methylation via CpG Dinucleotides in E2 Binding Sites -- 1.5 Effects of Papillomaviruses on the Cellular Epigenome -- 1.6 Differential Methylation of HPV Genomes in Malignant Lesions -- 1.7 HPV Epigenomes and Cellular Epigenomic Properties of HPV Infected Cells as Cancer Biomarkers -- References -- Chapter 2: Epigenetic Regulation of Gammaherpesviruses: A Focus on Kaposi´s Sarcoma-Associated Herpesvirus (KSHV/HHV-8) -- 2.1 Introduction -- 2.1.1 Genome Organization and Circularization -- 2.1.2 Gene Expression During Latency -- 2.1.3 Gene Expression During Lytic Phase -- 2.2 Histone Modifications -- 2.2.1 Histone Modifications During Gammaherpesvirus Latency -- 2.2.2 Histone Modifications During Lytic Reactivation -- 2.2.3 Intra- and Inter-locus Epigenetic Heterogeneity in KSHV Episomes -- 2.3 DNA Methylation -- 2.4 Chromatin Organization by CTCF and the Cohesin Complex -- 2.5 Noncoding RNAs and Epigenetic Control -- 2.6 Conclusions -- References -- Chapter 3: Discoveries in Molecular Genetics with the Adenovirus 12 System: Integration of Viral DNA and Epigenetic Consequenc... -- 3.1 Background on Interest in DNA Methylation and Epigenetic Effects -- 3.1.1 Introduction to the Adenovirus System -- 3.1.1.1 Ad12-Syrian Hamster Cells: The Abortive System -- 3.1.2 Foreign DNA in the Environment -- 3.1.3 Biology of Ad12-Induced Hamster Tumors -- 3.1.4 Characteristics of Chromosomally Integrated Adenovirus DNA -- 3.1.5 The Consequences of Inserting Foreign DNA into Established Mammalian Genomes
Content:
3.1.5.1 Hypermethylation of Integrated Ad12 DNA, the Transgenome -- 3.1.5.2 Promoter CpG Methylation and Promoter Silencing -- 3.1.5.3 Foreign DNA Integration into Mammalian Genomes Leads to Alterations in Methylation and Transcription Patterns -- Genome-Wide Increases in DNA Methylation in Ad12-Transformed Cells-Stability of Changes Even After the Loss of All Viral Genom... -- Alterations of Cellular DNA Methylation and Transcription Patterns Are Also Elicited in Bacteriophage Lambda or Bacterial Plas... -- Alterations of CpG Methylation Patterns Way Upstream of the FMR1 Boundary in Human Cells Immortalized by Epstein-Barr Virus (E... -- A Model System to Study the Epigenomic Destabilization in Human Cells Transgenomic for a 5.6 kbp Bacterial Plasmid -- 3.1.6 Résumé -- References -- Chapter 4: Epigenetic Consequences of Epstein-Barr Virus Infection -- 4.1 Epigenetic Regulation of the EBV Life Cycle -- 4.1.1 EBV Life Cycle -- 4.1.2 Epigenetic Control of Viral Promoter Usage -- 4.1.3 Epigenetic Regulation of Lytic Reactivation -- 4.2 Viral Protein Interactions with the Host Epigenetic Machinery -- 4.2.1 EBNA1 -- 4.2.2 EBNA2 -- 4.2.2.1 EBNA3 Family -- 4.2.2.2 EBNA-LP -- 4.2.3 The Latent Membrane Proteins -- 4.2.4 EBV Noncoding RNAs -- 4.3 Epigenetics of EBV-Associated Malignancies -- 4.3.1 Lymphoid Cells -- 4.3.2 Epithelial Cells -- 4.4 Concluding Remarks -- References -- Chapter 5: Epigenetic Programming by Microbial Pathogens and Impacts on Acute and Chronic Disease -- 5.1 Introduction -- 5.2 DNA Methylation -- 5.2.1 Bacterial Restriction Modification Systems -- 5.2.2 Solitary DNA Methyltransferases -- 5.2.2.1 Dam Methylase -- 5.2.2.2 Cytosine Methylases -- 5.2.2.3 CcrM Methylase -- 5.3 Dam Methylation Modulates the Timing and Targeting of Cellular Processes -- 5.3.1 Dam Controls DNA Repair and Replication
Content:
5.3.2 Dam Controls Bacterial Gene Expression -- 5.4 DNA Methylation Plays an Essential Role in Bacterial Virulence -- 5.4.1 DNA Methylation Controls Bacterial Pathogenesis -- 5.5 Perspectives: Epigenetic Programming of the Pathogen and Disease Susceptibility -- 5.6 Microbial Infection, Epigenetic Reprogramming, and Human Disease -- 5.6.1 Microbial Infection and Cancer -- 5.7 Concluding Remarks: Microbial Infection and Its Impact on the Host Epigenome and Disease -- References -- Chapter 6: Cross Talk Between Bacteria and the Host Epigenetic Machinery -- 6.1 Introduction -- 6.2 The Machinery of Chromatin Regulation -- 6.2.1 Chromatin Marks -- 6.2.2 Chromatin Regulators -- 6.2.3 Signaling to Chromatin -- 6.2.4 Epigenetic Inheritance -- 6.3 Bacterial Effects on the Host Epigenome -- 6.3.1 Lessons from Listeria and Anaplasma -- 6.3.1.1 Histone Modifications as a Host Response to Bacterial Molecular Patterns -- 6.3.1.2 Histone Modifications Induced by Bacteria-Induced Specific Signaling -- 6.3.1.3 Direct Control of the Chromatin-Regulatory Machinery by Bacterial Nucleomodulins: The LntA and AnkA Paradigms -- 6.3.1.4 Deregulation of Epigenetic Factor Genes and Genome-Wide Mediated Epigenetic Changes -- 6.3.2 Chromatin Modifications Driven by Bacteria: Additional Examples -- 6.3.2.1 Histone Modifications -- 6.3.2.2 DNA Methylation -- 6.3.3 Bacterial Nucleomodulins -- 6.3.3.1 Nucleomodulins Acting Via Protein-Protein or Protein-DNA Interactions -- 6.3.3.2 Nucleomodulins Acting as Epigenetic Modifiers -- 6.3.4 Change in Expression and/or Activity of Epigenetic Regulators -- 6.3.5 Bacterial Molecular Patterns Acting on the Epigenetic Machinery -- 6.4 Epigenetic Factors Engaged in Host Responses to Bacteria and Bacterial Imprinting -- 6.4.1 Lessons from BAHD1-, SIRT2-, and HDAC3-Deficient Mice -- 6.4.2 Immune Tolerance and Toxin-Induced Resistance
Content:
6.4.3 Trained Innate Immunity -- 6.4.4 Polymicrobial Infections and Viral Reactivation -- 6.5 Bacterial Reprogramming of Cell and Tissue Fate -- 6.5.1 Bacteria-Induced Cell Differentiation -- 6.5.2 Bacteria-Induced Cell Dedifferentiation -- 6.5.3 Bacteria-Induced Epithelial-Mesenchymal Transition and Oncogenesis -- 6.6 Conclusions -- References -- Chapter 7: Epigenetic Phase Variation in Bacterial Pathogens -- 7.1 Introduction -- 7.2 The Contribution of Epigenetic Phase Variation to Bacterial Pathogenesis -- 7.3 Core Principles of the Dam-Dependent Epigenetic Phase Variation -- 7.4 Dam-Dependent Epigenetic Regulation in Natural Isolates -- 7.5 Epigenetic Regulation in Pathogens by DNA Methyltransferases Other than Dam -- 7.6 What Lies Ahead? -- References -- Chapter 8: Epigenetic Switching in the Human Fungal Pathogen Candida albicans -- 8.1 Introduction -- 8.2 General Features of White-Opaque Switching -- 8.3 Genetic and Epigenetic Regulation of White-Opaque Switching in C. albicans -- 8.4 Environmental Regulation of White-Opaque Switching in C. albicans -- 8.5 Relationship Between White-Opaque Switching and Mating in C. albicans -- 8.6 White-Opaque Switching Regulates Filamentation and Biofilm Development -- 8.7 White-Opaque Switching and Pathogenesis -- 8.8 White-Gray-Opaque Tristable Switching -- 8.9 White-Opaque Switching in Candida dubliniensis and Candida tropicalis -- 8.10 Conclusion -- References -- Chapter 9: Modification of the Host Epigenome by Parasitic Protists -- 9.1 General Comments -- 9.1.1 Overview of Pathogenic Protists -- 9.1.2 Overview of Host Epigenetic Landscape -- 9.2 Alteration of DNA Methylation -- 9.3 Histone Modification and Chromatin Remodeling -- 9.4 Noncoding RNAs -- 9.5 Protozoan Effectors Reshape the Host Epigenome -- 9.6 Commonly Targeted Pathways -- 9.7 Concluding Remarks -- References
Content:
Chapter 10: Epigenetic Regulation in T. brucei: Changing Coats Is a Chance to Survive -- 10.1 Introduction -- 10.2 The Unusual T. brucei Genome and Transcription -- 10.3 Antigenic Variation Is Crucial for Immune Evasion -- 10.4 Epigenetics in T. brucei -- 10.4.1 Nuclear and Chromatin Organization -- 10.4.2 Histones and Chromatin Regulators -- 10.5 Epigenetic Control of T. brucei Antigenic Variation -- 10.5.1 How Are BESs Maintained Silent? -- 10.5.2 How Is a BES Maintained Active? -- 10.5.3 How Do BESs Undergo Transcriptional Switching? -- 10.6 Future Perspectives -- References -- Chapter 11: Epigenetics of Malaria Parasites -- 11.1 The Malaria Parasite Life Cycle -- 11.2 Transcriptional Regulation in Plasmodium -- 11.3 Epigenetic Regulation of Virulence Genes -- 11.3.1 P. falciparum Virulence Genes -- 11.3.2 Histone Posttranslational Modifications -- 11.3.3 Proteins Involved in Regulating var Gene Expression -- 11.3.4 var Gene Switching -- 11.3.5 Long Noncoding RNAs -- 11.4 Epigenetic Regulation of Other Clonally Variant Genes -- 11.4.1 Solute Transporters -- 11.4.2 Invasion Genes -- 11.5 Epigenetic Regulation of Gametocytogenesis -- 11.6 Local Chromatin Structure -- 11.7 Nuclear Architecture -- 11.8 Epigenetic Mechanisms as Drug Targets -- 11.9 Conclusions -- References -- Glossary of Terms for Epigenetics of Infectious Diseases
Additional Edition:
9783319550190
Additional Edition:
Print version Doerfler, Walter Epigenetics of Infectious Diseases Cham : Springer International Publishing,c2017 9783319550190
Language:
English
URL:
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