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  • 1
    UID:
    (DE-605)HT020544586
    Format: 1 Online-Ressource (XI, 137 p. 69 illus., 21 illus. in color)
    Edition: 1st ed. 2020
    ISBN: 9783030157623
    Series Statement: Southern Space Studies
    Additional Edition: Printed edition 9783030157616
    Additional Edition: Printed edition 9783030157630
    Additional Edition: Printed edition 9783030157647
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Divison of Clinical Genetics, Lund University
    UID:
    (DE-627)180329227X
    Content: The general aim of this thesis was to molecularly characterize urothelial carcinoma (UC) at the transcriptional level using gene expression microarrays to improve the classification and pathogenetic understanding of this disease. In the first two studies (Articles I and II), gene expression profiling was used to study dysregulated transcriptional networks in a large cohort of UCs. We also investigated possible associations between the expression profiles and tumor stage/grade, or mutation status of FGFR3/TP53 and LOH for chromosome 9. It was shown that the mutational status of FGFR3 and TP53 correlated with large transcriptional differences, thus indicating for two different molecular pathways of UC development. Furthermore, we found gene signatures associated with specific biological functions that correlated with molecular and histological subgroups. Finally, a high expression of MHC-class I related genes in patients with muscle-invasive tumors provided independent prognostic information for lymph-node status and overall survival. In the third study (Article III), the genetic relation between syn- or metachronous tumors was explored, revealing that the expression profile is remarkably stable in tumors collected from the same patient, despite large genomic differences. This suggests that the formation of a fixed expression profile may be an early event in the development of UC. In the final study (Article IV), we combined high-resolution BAC arrays with gene expression profiling and could show that E2F3, CDKAL1, and SOX4 in 6p22, and YWHA (14-3-3) gene family members in 8q22 and 2p25, respectively, are major target oncogenes important for high grade disease.
    Note: Dissertation Divison of Clinical Genetics, Lund University 2006
    Language: English
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  • 3
    Online Resource
    Online Resource
    Cham : Springer International Publishing | Cham : Springer International Publishing AG
    UID:
    (DE-603)467469172
    Format: 1 Online-Ressource (XI, 137 Seiten) , 69 illus., 21 illus. in color.
    Edition: 1st ed. 2020
    ISBN: 9783030157623 , 3030157628
    Series Statement: Southern Space Studies
    Additional Edition: Erscheint auch als Druck-Ausgabe Lindgren, David An Assessment Framework for Compliance with International Space Law and Norms Cham : Springer International Publishing, 2020 9783030157616
    Additional Edition: 9783030157616
    Additional Edition: 9783030157630
    Additional Edition: 9783030157647
    Language: English
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  • 4
    UID:
    (DE-627)1770498737
    Format: 1 online resource (144 pages)
    ISBN: 9783030157623
    Series Statement: Southern Space Studies
    Content: Intro -- Preface -- Contents -- About the Author -- Abbreviations and Acronyms -- 1 Introduction -- Abstract -- 1.1 Objectives of this Research -- 1.2 Evidence-Based Programming and Policymaking -- 1.3 Ratings and Rankings Research -- 1.4 Structure of this Book -- 2 Existing Ratings and Rankings Systems -- Abstract -- 2.1 Ratings and Rankings Systems: Economics and Business -- 2.2 Select Ratings and Rankings Systems and Associated Challenges -- 2.3 The Space Security Index -- 2.4 Gaps in Existing Space Policy Research -- 3 International Space Law and Norms -- Abstract -- 3.1 Differences in Binding and Non-binding International Instruments -- 3.2 Binding International Space Law Treaties -- 3.3 Binding International Space-Related Treaties -- 3.4 Non-binding International Principles, Resolutions, and Guidelines -- 4 Elements Comprising Assessment Methodologies -- Abstract -- 4.1 What Precisely Does It Aim to Measure? -- 4.2 Does the Operational Definition Capture the Concept? -- 4.3 How Good (Reliable, Valid, and Complete) Are the Data? -- 4.4 Is the Measure (Including All of Its Sub-components) Transparent and Replicable? -- 4.5 How Sensitive and Robust Is the Measure to Different Data and Design Choices? -- 4.6 Does the Measure Address Key Questions of Interest? -- 4.7 Does the Measure Fully Capture Governance in All Its Complexity? -- 4.8 Does the Measure Behave as Theory Predicts? -- 4.9 How Precisely Can Index Values and Confidence Intervals Be Specified? -- 4.10 Is the Weighting Correct? -- 5 Framework for Assessing Compliance -- Abstract -- 5.1 Review of the Framework -- 5.1.1 General Scoring of the Framework -- 5.1.2 Weighting of the Framework -- 5.1.3 Aggregate Scoring of the Framework -- 5.1.4 Scoring of Space-Specific International Treaties -- 5.1.5 Scoring of Space-Related International Treaties.
    Note: Description based on publisher supplied metadata and other sources
    Additional Edition: 9783030157616
    Additional Edition: Erscheint auch als Druck-Ausgabe 9783030157616
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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  • 5
    UID:
    (DE-627)1687551324
    ISBN: 3319789538
    In: Post 2030-agenda and the role of space, Cham : Springer, 2018, (2018), Seite 11-25, 3319789538
    In: 9783319789538
    In: year:2018
    In: pages:11-25
    Language: English
    Keywords: Aufsatz im Buch
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  • 6
    UID:
    (DE-602)b3kat_BV046889957
    Format: 1 Online-Ressource (XI, 137 Seiten) , Illustrationen
    ISBN: 9783030157623
    Series Statement: Southern space studies
    Content: Introduction -- Existing ratings and rankings systems -- International space law and norms -- Elements comprising assessment methodologies -- Framework for assessing compliance -- Conclusions
    Content: This book proposes a framework for assessing countries’ levels of compliance with international space law and norms. It begins by exploring the development of two movements – the evidence-based policymaking and programming movement, and the rise of ratings and rankings research – and their growth across various disciplines. The analysis suggests that such efforts are useful in gauging the behavior of countries in space according to how well they adhere to existing space law and norms. To date, there is no comprehensive, periodic, and systematic measure of countries’ efforts to comply with space law and norms; this work endeavors to fill that gap by offering a framework in which to assess compliance. Applying the framework results in five possible ratings that a country may be assigned, ranging from highly compliant to non-compliant. Ideally, the proposed framework can be used to promote compliance, and with it, space security and sustainability
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-15761-6
    Language: English
    Subjects: Law
    RVK:
    URL: Volltext  (URL des Erstveröffentlichers)
    URL: Cover
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  • 7
    UID:
    (DE-605)HT014934430
    Format: Getr. Zählung : Ill., graph. Darst.
    ISBN: 918555927X
    Series Statement: Doctoral dissertation series 20066,103
    Note: Lund, Univ., Diss., 2006 , Zsfassung in schwed. Sprache
    Language: English , Swedish
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  • 8
    Book
    Book
    Linköping : Univ.
    UID:
    (DE-627)476893453
    Format: VIII, 189 S , graph. Darst
    ISBN: 9185297062
    Series Statement: Linköping studies in science and technology 915
    Note: Zugl.: Linköping, Univ., Diss., 2005
    Language: English
    Keywords: Nichtlineares System ; Systemidentifikation ; Klassifikationstheorie ; Projektionsverfahren ; Hochschulschrift
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  • 9
    UID:
    (DE-627)1726028909
    Format: 1 Online-Ressource(XI, 137 p. 69 illus., 21 illus. in color.)
    Edition: 1st ed. 2020.
    ISBN: 9783030157623
    Series Statement: Southern Space Studies
    Content: Introduction -- Existing ratings and rankings systems -- International space law and norms -- Elements comprising assessment methodologies -- Framework for assessing compliance -- Conclusions.
    Content: This book proposes a framework for assessing countries’ levels of compliance with international space law and norms. It begins by exploring the development of two movements – the evidence-based policymaking and programming movement, and the rise of ratings and rankings research – and their growth across various disciplines. The analysis suggests that such efforts are useful in gauging the behavior of countries in space according to how well they adhere to existing space law and norms. To date, there is no comprehensive, periodic, and systematic measure of countries’ efforts to comply with space law and norms; this work endeavors to fill that gap by offering a framework in which to assess compliance. Applying the framework results in five possible ratings that a country may be assigned, ranging from highly compliant to non-compliant. Ideally, the proposed framework can be used to promote compliance, and with it, space security and sustainability.
    Additional Edition: 9783030157616
    Additional Edition: 9783030157630
    Additional Edition: 9783030157647
    Additional Edition: Erscheint auch als Druck-Ausgabe 9783030157616
    Additional Edition: Erscheint auch als Druck-Ausgabe 9783030157630
    Additional Edition: Erscheint auch als Druck-Ausgabe 9783030157647
    Language: English
    URL: Cover
    Library Location Call Number Volume/Issue/Year Availability
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  • 10
    UID:
    (DE-604)BV046889957
    Format: 1 Online-Ressource (XI, 137 Seiten) , Illustrationen
    ISBN: 9783030157623
    Series Statement: Southern space studies
    Content: Introduction -- Existing ratings and rankings systems -- International space law and norms -- Elements comprising assessment methodologies -- Framework for assessing compliance -- Conclusions
    Content: This book proposes a framework for assessing countries’ levels of compliance with international space law and norms. It begins by exploring the development of two movements – the evidence-based policymaking and programming movement, and the rise of ratings and rankings research – and their growth across various disciplines. The analysis suggests that such efforts are useful in gauging the behavior of countries in space according to how well they adhere to existing space law and norms. To date, there is no comprehensive, periodic, and systematic measure of countries’ efforts to comply with space law and norms; this work endeavors to fill that gap by offering a framework in which to assess compliance. Applying the framework results in five possible ratings that a country may be assigned, ranging from highly compliant to non-compliant. Ideally, the proposed framework can be used to promote compliance, and with it, space security and sustainability
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-15761-6
    Language: English
    Subjects: Law
    RVK:
    URL: Volltext  (URL des Erstveröffentlichers)
    URL: Cover
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
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