Format:
1 Online-Ressource (15 Seiten)
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Illustrationen, Diagramme
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Supplemental information
ISSN:
2211-1247
Content:
Abstract: Immunity following an acutely resolved infection or the long-term equipoise of chronic viral infections often depends on the maintenance of antigen-specific CD8+ T cells, yet the ongoing transcriptional requirements of these cells remain unclear. We show that active and continuous programming by FOXO1 is required for the functional maintenance of a memory population. Upon Foxo1 deletion following resolution of an infection, memory cells rapidly lost their characteristic gene expression, gradually declined in number, and were impaired in self-renewal. This was extended to chronic infections, as a loss of FOXO1 during a persistent viral infection led to a rapid decline of the TCF7 (a.k.a. TCF1)-expressing memory-like subset of CD8+ T cells. We further establish FOXO1 regulation as a characteristic of human memory CD8+ T cells. Overall, we show that the molecular and functional longevity of a memory T cell population is actively maintained by the transcription factor FOXO1
In:
Cell reports, 22, 13 (2018), 3454-3467, 2211-1247
Language:
English
DOI:
10.1016/j.celrep.2018.03.020
URN:
urn:nbn:de:bsz:25-freidok-1449502
URL:
https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-1449502
URL:
https://d-nb.info/1234388197/34
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