Format:
xi, 621 p.
,
ill.
ISBN:
9780123878304
Content:
This book identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluations of treatments. The book is aimed at all students of bone biology and genetics, and with this in mind, it includes general introductory chapters on genetics and bone biology and more specific disease-orientated chapters, which comprehensively summarize the clinical, genetic, molecular genetic, animal model, functional and molecular pathology, diagnostic, counselling and treatment aspects of each disorder. Saves academic, medical, and pharma researchers time in quickly accessing the very latest details on a broad range of genetic bone issues, as opposed to searching through thousands of journal articles. Provides a common language for bone biologists and geneticists to discuss the development of bone cells and genetics and their interactions in the development of disease Researchers in all areas bone biology and genetics will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays For those clinical researchers who are also MDs, correct diagnosis (and therefore correct treatment) of bone diseases depends on a strong understanding of the molecular basis for the disease.
Content:
Front Cover -- Genetics of Bone Biology and Skeletal Disease -- Copyright Page -- Contents -- Preface -- List of Contributors -- I. General Background to Bone Biology -- 1 Biology of Bone and Cartilage -- I. Introduction -- II. Osteoclasts -- Regulation of Osteoclast Formation: The RANKL-RANK-OPG System -- Transcription Factor Regulation of Osteoclastogenesis -- RANKL/RANK Downstream Signaling -- Regulation of Osteoclast Activation -- Negative Regulation of Osteoclast Formation and Function -- Osteoclast Apoptosis -- III. Osteoblasts -- Regulation of Osteoblast Formation -- Runx2 -- Osterix (Osx) -- Bone Morphogenetic Proteins -- Wingless (Wnt) -- Notch -- Regulation of Matrix Proteins -- Activating Transcription Factor (ATF) and Activator Protein 1 (AP-1) -- Type I Collagen Modification -- Regulation of Osteoblast Communication -- Ephrins -- Semaphorins -- Neural Regulation of Bone Formation -- Negative Regulation of OB Function -- IV. Cartilage -- Chondrocytes -- Endochondral Ossification -- Endochondral Ossification in the Adult Skeleton -- Formation of the Articular Cartilages -- Cartilage Degeneration -- References -- 2 Overview of Bone Structure and Strength -- I. Introduction -- II. Bone Biomechanics and the Determinants of Whole Bone Strength -- Structural vs Material Properties of Bone -- Mechanical Properties of Bone Tissue Depend on Loading Direction -- Determinants of Biomechanical Properties of Trabecular and Cortical Bone -- III. Contribution of Bone Geometry to Bone Strength -- Age-Related Changes in Bone Size and Shape -- IV. Age-Related Changes in Trabecular and Cortical Bone Microarchitecture -- V. Contribution of Bone Microarchitecture to Bone Strength -- Trabecular Microarchitecture -- Age-Related Changes in Cortical and Trabecular Bone Material Properties -- Contribution of Bone Structure to Vertebral Strength.
Note:
Includes bibliographical references and index
Additional Edition:
9780123878298
Additional Edition:
Erscheint auch als Druck-Ausgabe 9780123878298
Language:
English
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