Umfang:
Online-Ressource
ISSN:
1661-7819
Inhalt:
Background: Deep medullary vein (DMV) thrombosis is a rare cause of brain damage in both preterm and full-term neonates. In this study, we aimed to collect data on clinical and radiological presentation, treatment, and outcome of neonatal DMV thrombosis. Methods: Systematic literature review on neonatal DMV thrombosis was carried out in PubMed, ClinicalTrial.gov, Scopus, and Web of Science up to December 2022. Results: Seventy-five published cases of DMV thrombosis were identified and analysed (preterm newborns were 46%). Neonatal distress, respiratory resuscitation, or need for inotropes were present in 34/75 (45%) of patients. Signs and symptoms at presentation included seizures (38/75, 48%), apnoea (27/75, 36%), lethargy or irritability (26/75, 35%). At magnetic resonance imaging (MRI), fan-shaped linear T2 hypointense lesions were documented in all cases. All had ischaemic injuries, most often involving the frontal (62/74, 84%) and parietal lobes (56/74, 76%). Signs of haemorrhagic infarction were present in 53/54 (98%). Antithrombotic treatment was not mentioned in any of the studies included. Although mortality was low (2/75, 2.6%), a large proportion of patients developed neurological sequelae (intellectual disability in 19/51 [37%] and epilepsy in 9/51 [18%] cases). Conclusions: DMV thrombosis is rarely identified in the literature, even if it is possibly under-recognized or under-reported. Presentation in neonatal age is with seizures and non-specific systemic signs/symptoms that often cause diagnostic delay, despite the pathognomonic MRI picture. The high rate of morbidity, which determines significant social and health costs, requires further in-depth studies aimed at earlier diagnosis and evidence-based prevention and therapeutic strategies.
In:
volume:120
In:
number:5
In:
year:2023
In:
pages:539-547
In:
extent:9
In:
Neonatology, Basel ; Freiburg, Br. ; Paris ; London ; New York ; Bangalore ; Bangkok ; Singapore ; Tokyo ; Sydney : Karger, 2007-, 120, Heft 5 (2023), 539-547 (gesamt 9), 1661-7819
Sprache:
Englisch
URN:
urn:nbn:de:101:1-2023101200342751804175
URL:
https://doi.org/10.1159/000530647
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023101200342751804175
URL:
https://d-nb.info/1305743822/34
URL:
https://karger.com/neo/article-pdf/doi/10.1159/000530647/3931384/000530647.pdf
URL:
https://karger.com/doi/10.1159/000530647
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