Format:
Online-Ressource
ISSN:
1521-3927
Content:
Hypoxia plays a critical role in the development and wound healing process, as well as a number of pathological conditions. Here, dextran‐based hypoxia‐inducible (Dex‐HI) hydrogels formed with in situ oxygen consumption via a laccase−medicated reaction are reported. Oxygen levels and gradients were accurately predicted by mathematical simulation. It is demonstrated that Dex‐HI hydrogels provide prolonged hypoxic conditions up to 12 h. The Dex‐HI hydrogel offers an innovative approach to delineate not only the mechanism by which hypoxia regulates cellular responses, but may facilitate the discovery of new pathways involved in the generation of hypoxic and oxygen gradient environments.
In:
volume:35
In:
number:22
In:
year:2014
In:
pages:1968-1975
In:
extent:8
In:
Macromolecular rapid communications, Weinheim : Wiley-VCH, 1980-, 35, Heft 22 (2014), 1968-1975 (gesamt 8), 1521-3927
Language:
English
DOI:
10.1002/marc.201400369
URN:
urn:nbn:de:101:1-2023012205174000845757
URL:
https://doi.org/10.1002/marc.201400369
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023012205174000845757
URL:
https://d-nb.info/1278826521/34
URL:
https://doi.org/10.1002/marc.201400369
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