Format:
1 online resource (362 pages)
,
illustrations (some color)
Edition:
Third edition.
ISBN:
9780444627162
Series Statement:
Issn Ser. v.Volume 12
Content:
Completely revised and updated, Human Herpesviruses HHV-6A, HHV-6B & HHV-7, Third Edition, delivers a contemporary and thorough review of HHV-6, beginning with foundational explorations of classification, molecular biology, and chromosomal integration of the virus, through to clinical details, including pathologic features of infection, and clinical effects on various organ systems. The work now includes coverage of HHV-7, a virus that remains underestimated in transplant reactivation, seizures, and encephalitis. The book examines the role of HHV-6 in myriad diseases, including cognitive disorders following bone marrow transplant, mesial temporal lobe epilepsy, multiple sclerosis, autoimmune disease, encephalitis, Hodgkin's disease lymphoma (HHV-6B), and glioma (HHV-6A). Descriptions of current and novel molecular and serological diagnostic assays, along with detailed protocols, are included to aid researchers and clinicians in discriminating potential false positives originating from chromosomally integrated HHV-6, and in differentiating between active and latent infection. Human Herpesviruses HHV-6A, HHV-6B & HHV-7, Third Edition is a valuable reference for both clinical and basic scientists, including epidemiologists, virologists, practicing clinicians, infectious disease specialists, pathologists, and all scientists entering the field of herpes virus research. The work is a practical and thorough resource for a foundational understanding of HHV-6 and HHV-7, while providing a cutting-edge translational and clinical reference to those looking to understand and diagnose associated viral diseases. Delivers the latest molecular diagnostic tests, the present-day gold standard for monitoring HHV-6 Provides expert analysis of T-cell immune response against HHV-6 Presents tools for differential diagnosis in HHV-6 viral infections Includes new
Content:
Front Cover -- Human Herpesviruses HHV-6A, HHV-6B, and HHV-7 -- Copyright Page -- Contents -- List of Contributors -- Foreword by Philip E. Pellett -- Foreword by Yoshizo Asano -- Dedication -- 1 HHV-6A and HHV-6B Officially Classified as Distinct Viruses -- Introduction and Classification History -- Distinct Epidemiology and Disease Associations -- Acknowledgment -- References -- 2 Practical Diagnostic Procedures for HHV-6A, HHV-6B, and HHV-7 -- An Overview of Diagnostic Strategies -- Objectives -- Direct and Indirect Approaches -- Specimens -- Methods of Direct Diagnosis -- Cell Culture -- Antigen Detection -- Nucleic Acid Detection, Quantitation, and Sequencing -- Detection of DNA by in situ Hybridization -- Detection and Quantitation of DNA by PCR and Real-Time PCR -- Detection and Quantitation of Transcripts by RT-PCR -- Nucleotide Sequencing -- Differential Diagnosis of HHV-6A and HHV-6B Infection -- Antiviral Susceptibility Assays -- Serologic Methods -- Techniques -- Viral Antigens Used for Serologic Testing -- Characterization of Specific Antibodies -- Indications and Findings -- Primary Infection -- Chronic Infection and Reactivations -- Chromosomal Integration -- Epidemiology -- Therapeutic Follow-Up -- Conclusions: Practical Management of Diagnosis -- References -- 3 Pathologic Features of HHV-6A, HHV-6B, and HHV-7 Infection (Light and Electron Microscopy) -- Introduction -- Viral Infection and Pathogenesis -- Morphogenesis of Cell and Tissue Lesions -- Anatomic (Systemic) Pathology of Tissues and Organs -- Diagnostic Criteria -- Pathologic Lesions in Primary Infection -- Viral Persistence and Chromosomal Integration -- Pathologic Lesions in Reactivation and Endogenous Reinfection -- Morphology of Organ Systems in Reactivated Infections -- Cardiovascular System -- Respiratory System -- Gastrointestinal System.
Note:
Includes bibliographical references and index. Description based on online resource; title from PDF title page (ebrary, viewed March 8, 2014)
Additional Edition:
9780444627032
Additional Edition:
Erscheint auch als Druck-Ausgabe 9780444627032
Language:
English
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