Format:
1 online resource (332 pages)
ISBN:
9781848164666
Content:
"Emerging Topics in Physical Virology" is a state-of-the-art account of recent advances in the experimental analysis and modeling of structure, function and dynamics of viruses. It is the first interdisciplinary book that integrates a review of relevant experimental techniques, such as cryo-electron microscopy, atomic force microscopy and mass spectrometry with the latest results on the biophysical and mathematical modeling of viruses. The book comprehensively covers the structure and physical properties of the protein envelopes that encapsulate and hence protect the delicate viral genome, their assembly and disassembly, the organization of the viral genome, infection, evolution, as well as applications of viruses in Biomedical Nanotechnology. It is an essential primer for scientists working in all aspects of virology, including the increasing use of viruses and virus-like particles in bio- and nano-technology. Its review style makes it moreover suitable for non-experts as an introduction into this exciting research area.
Content:
Intro -- Contents -- Contributors -- Preface -- Chapter 1: Cryo-Electron Microscopy of Viruses Neil A. Ranson and Peter G. Stockley -- 1. Introduction -- 2. The Cryo-EM Technique -- 3. Determining the 3-D Structure of Viruses from EM Data -- 4. Complementarity between Cryo-EM versus X-ray Methods -- 5. Structure of Large Enveloped Viruses -- 6. Virus - Receptor Interactions -- 7. Maturation Processes -- 8. Structural Information on Packaged Genomes -- 9. Prospects for Cryo-EM of Viruses at Atomic Resolution -- 10. Pleiomorphic Viruses and the Power of Cryo-Electron Tomography -- 11. Conclusions -- References -- Chapter 2: What Does it Take to Make a Virus: The Concept of the Viral 'Self' Nicola G. A. Abrescia, Jonathan M. Grimes, Elizabeth E. Fry, Janne J. Ravantti, Dennis H. Bamford and David. I. Stuart -- 1. Introduction -- 2. Towards the Concept of Viral Lineage? -- 3. The Double-Barrel Paradigm Lineage -- 4. Picorna-Like Group - Single Barrel, Single Lineage? -- 5. More Phages, a Different Lineage -- 6. dsRNA Genome - A Constraint on Architecture? -- 7. Enveloped Viruses - Infectious Vesicles? -- 8. The Viral Self and Emerging Viruses -- 9. Conclusions -- Acknowledgements -- References -- Chapter 3: Beyond Quasi-Equivalence: New Insights Into Viral Architecture via Affine Extended Symmetry Groups Thomas Keef and Reidun Twarock -- 1. Introduction - Symmetry in Virus Architecture -- 2. The Surface Structures of Viral Capsids: Viral Tiling Theory -- 2.1. Quasi-Equivalent Tessellations Beyond Triangulations -- 2.2. All-Pentamer Capsids in Viral Tiling Theory -- 3. Generalisation of the Symmetry Group via Affine Extension -- 4. Applications to Viruses -- 4.1. Prediction of Particle Sizes in Assembly Polymorphism -- 4.2. Prediction of Genome Organisation -- 4.3. Predictions of Protein Structure -- 4.4. Implications for Viral Dynamics.
Note:
Description based on publisher supplied metadata and other sources
Additional Edition:
9781848164642
Additional Edition:
Erscheint auch als Druck-Ausgabe Emerging topics in physical virology London : Imperial College Press, 2010 9781848164642
Additional Edition:
1848164645
Language:
English
Subjects:
Biology
URL:
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