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  • 1
    UID:
    gbv_50106608X
    Format: XI, 198 S. , Ill., graph. Darst.
    ISBN: 1573315435 , 1573315443
    Series Statement: Annals of the New York Academy of Sciences 1059
    Note: Includes bibliographical references and index
    Language: English
    Subjects: Medicine
    RVK:
    Keywords: Therapieresistenz ; Tumorwachstum ; Metastase ; Tumor ; Maligne Transformation ; Arzneimittelresistenz ; Konferenzschrift
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Online Resource
    Online Resource
    Totowa, NJ : Humana Press
    UID:
    b3kat_BV036726393
    Format: 1 Online-Ressource
    Edition: Online-Ausgabe Springer ebook collection. Medicine 2005-2008
    ISBN: 9781592598519
    Series Statement: Cancer drug discovery and development
    Note: Includes bibliographical references and index
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-1-58829-172-1
    Language: English
    Subjects: Medicine
    RVK:
    Keywords: Krebs ; Apoptosis
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  • 3
    Online Resource
    Online Resource
    Totowa, NJ :Humana Press :
    UID:
    almahu_9949251230602882
    Format: 1 online resource (526 p.)
    Edition: 1st ed. 2003.
    ISBN: 1-280-84212-1 , 9786610842124 , 1-59259-328-3
    Series Statement: Methods in Molecular Biology, 222
    Content: Powerful new tools are now available to discover and understand tumor suppressor genes (TSGs) and the biochemical mechanisms by which they control cancer development and progression. In Tumor Suppressor Genes, Volume 1: Pathways and Isolation Strategies, leading physician scientists and academic researchers review all the known tumor suppressor genes, explain how they work, and describe how they were discovered and isolated. In many cases, the authors discuss specific genes that are frequently involved in hereditary or sporadic cancers. They also provide a detailed guide to using powerful molecular genetic, cytogenetic, proteomic, and cell biological strategies to isolate and characterize novel tumor suppressor genes and their targets. The companion volume of this set, Tumor Suppressor Genes, Volume 2: Regulation, Function, and Medicinal Applications, demonstrates how best to explore the cell biology and biochemical function of such genes, and their encoded proteins, to study their physiological role in vivo, and to use information on TSGs to develop diagnostic and therapeutic strategies for cancer. Comprehensive and authoritative, the two volumes of Tumor Suppressor Genes provide an unparalleled compilation of key data on all known tumor suppressor pathways and a treasury of techniques for their discovery, analysis, and uses in cancer therapeutics.
    Note: Description based upon print version of record. , Known Tumor Suppessor Genes and Pathways -- Growth Control by the Retinoblastoma Gene Family -- The APC Tumor Suppressor Pathway -- Hereditary Breast and Ovarian Cancer Genes -- Hereditary Colon Cancer Genes -- Patched, Hedgehog, and Skin Cancer -- Tumor Suppressor Genes in Lung Cancer -- TP53, hChk2, and the Li-Fraumeni Syndrome -- Genetic Alterations in Esophageal Cancer -- PTEN and Cancer -- VHL and Kidney Cancer -- p16INK4A and Familial Melanoma -- The INK4a/ARF Locus and Human Cancer -- Progression Model of Prostate Cancer -- Neurofibromatosis Type 1 -- Wilms’ Tumor as a Model for Cancer Biology -- Inadequate “Caretaker” Gene Function and Human Cancer Development -- The Regulation of Tumor Suppressor Genes by Oncogenes -- Identification of Tumor Suppressor Genes -- Determination of Cancer Allelotype -- Epidemiological Approaches to the Identification of Cancer Predisposition Genes -- Characterization of Translocations in Human Cancer -- Positional Approaches to Cancer Genetics -- Hybrid Capture of Putative Tumor Suppressor Genes -- Approaches to Proteomic Analysis of Human Tumors -- Representational Difference Analysis of Gene Expression -- Antisense Libraries to Isolate Tumor Suppressor Genes -- Genetic Suppressor Elements in the Characterization and Identification of Tumor Suppressor Genes -- Cross-linking Subtractive Hybridization to Identify Tumor Suppressor Genes -- Suppression Subtractive Hybridization for Identification and Functional Analysis of Tumor Suppressor Genes -- SAGE as a Strategy to Isolate Cancer-Related Genes -- Differential Display Techniques to Identify Tumor Suppressor Gene Pathways -- Detection of Mismatch Repair Gene Expression in Urologic Malignancies. , English
    Additional Edition: ISBN 0-89603-986-2
    Language: English
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  • 4
    UID:
    almahu_9949251231502882
    Format: 1 online resource (680 p.)
    Edition: 1st ed. 2003.
    ISBN: 1-280-84213-X , 9786610842131 , 1-59259-329-1
    Series Statement: Methods in Molecular Biology, 223
    Content: Powerful new tools are now available to discover and understand tumor suppressor genes (TSGs) and the biochemical mechanisms by which they control cancer development and progression. In Tumor Suppressor Genes, Volume 2: Regulation, Function, and Medicinal Applications, leading physician scientists and researchers explore the cell biology and biochemical function of the tumor suppressor genes, as well as their physiological role in vivo. The authors detail the physical methods-NMR, microarray approaches, posttranslational structure analysis, analysis of regulation at the gene expression and protein signaling levels-used to understand the function of tumor suppressor genes. In vivo approaches discussed include studies in yeast, Drosophila, mice, and human tumors. The authors also discuss how one ultimately derives a "tumor progression model," the drug discovery process, and the weaknesses of cancers that allow drugs to selectively kill them. Other aspects reviewed include screening strategies, targeting the blood supply of tumors, and the replacement of defective cancer genes to achieve a therapeutic effect. The companion volume of this set, Tumor Suppressor Genes, Volume 1: Pathways and Isolation Strategies, covers all known tumor suppressor genes, describing their cellular signaling pathways, how they were discovered, how they can be analyzed, and how they can be optimally used in cancer therapeutics Comprehensive and authoritative, the two volumes of Tumor Suppressor Genes provide an unparalleled compilation of key data on all known tumor suppressor pathways and a treasury of techniques for their discovery, analysis, and uses in cancer therapeutics.
    Note: Description based upon print version of record. , Understanding the Function and Regulation of Tumor Suppressor Genes -- Utilizing NMR to Study the Structure of Growth-Inhibitory Proteins -- Generation and Application of Phospho-specific Antibodies for p53 and pRB -- Stability and Ubiquitination of the Tumor Suppressor Protein p53 -- Role of Tumor Suppressors in DNA Damage Response -- In Situ Hybridization in Cancer and Normal Tissue -- Genetic Strategies in Saccharomyces cerevisiae to Study Human Tumor Suppressor Genes -- Electrophoretic Mobility Shift Analysis of the DNA Binding of Tumor Suppressor Gene Products -- Analysis of Gene Promoter Regulation by Tumor Suppressor Genes -- DNA Footprinting -- Identification of DNA-Binding of Tumor Suppressor Genes by Chromatin Immunoprecipitation -- Co-immunoprecipitation of Tumor Suppressor Protein-Interacting Proteins -- Microarray Approaches for Analysis of Tumor Suppressor Gene Function -- Analysis of Tumor Suppressor Gene-Induced Senescence -- Yeast Two-Hybrid Screening as a Means of Deciphering Tumor Suppressor Pathways -- Somatic Cell Knockouts of Tumor Suppressor Genes -- Colony Growth Suppression by Tumor Suppressor Genes -- Flow Cytometric Analysis of Cell Cycle Control by Tumor Suppressor Genes -- Analysis of Cyclin-Dependent Kinase Activity -- Tumor Suppressor Gene-Inducible Cell Lines -- In Vitro Models of Early Neoplastic Transformation of Human Mammary Epithelial Cells -- Tumor Suppression Through Angiogenesis Inhibition -- Flow Cytometric Analysis of Tumor Suppressor Gene-Induced Apoptosis -- Functional Analysis of Tumor Suppressor Genes in Mice -- The Tissue Microenvironment as an Epigenetic Tumor Modifier -- Analyzing the Function of Tumor Suppressor Genes Using a Drosophila Model -- Assembling a Tumor Progression Model -- Conformation-Sensitive Gel Electrophoresis for Detecting BRCA1 Mutations -- Medicinal Applications of Tumor Suppessors -- Conversion Technology and Cancer Predispositions -- Discovering Novel Anticancer Drugs -- Targets in Apoptosis Signaling -- Tumor Deprivation of Oxygen and Tumor Suppressor Gene Function -- Hormonal and Differentiation Agents in Cancer Growth Suppression -- Regulation of NF-?B by Oncoproteins and Tumor Suppressor Proteins -- Blocking Survivin to Kill Cancer Cells -- Targeting the Mitochondria to Enhance Tumor Suppression -- Novel Approaches to Screen for Anticancer Drugs Using Saccharomyces cerevisiae -- Tumor Suppressor Gene Therapy -- Therapeutic Strategies Using Inhibitors of Angiogenesis -- Isolation of p53 Inhibitors by Screening Chemical Libraries in Cell-Based Readout System. , English
    Additional Edition: ISBN 0-89603-987-0
    Language: English
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  • 5
    Book
    Book
    Totowa, NJ : Humana Press
    UID:
    gbv_362742383
    Format: XIX, 504 S. , Ill., graph. Darst. , 26 cm
    ISBN: 0896039862 , 1592593283
    Series Statement: Tumor suppressor genes Vol. 1
    Note: Literaturangaben
    Language: English
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  • 6
    Book
    Book
    Totowa, NJ : Humana Press
    UID:
    gbv_362742561
    Format: XIX, 657 S. , Ill., graph. Darst. , 26 cm
    ISBN: 0896039870 , 1592593291
    Series Statement: Tumor suppressor genes Vol. 2
    Note: Literaturangaben
    Language: English
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  • 7
    Book
    Book
    Totowa, NJ : Humana Press
    UID:
    gbv_353046647
    Format: 26 cm
    Series Statement: Methods in molecular biology ...
    Note: Erschienen: 1 - 2
    Language: English
    Subjects: Biology
    RVK:
    Keywords: Krebs ; Tumorsuppressor-Gen
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  • 8
    Book
    Book
    New York [u.a.] :Springer,
    UID:
    almahu_BV040795667
    Format: VIII, 446 S. : , Ill., graph. Darst.
    ISBN: 978-1-4614-6175-3 , 978-1-4614-6176-0
    Series Statement: Advances in experimental medicine and biology 779
    Language: English
    Subjects: Biology
    RVK:
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  • 9
    Online Resource
    Online Resource
    Totowa, N.J. :Humana Press,
    UID:
    edoccha_9958125370202883
    Format: 1 online resource (388 p.)
    ISBN: 1-280-35819-X , 9786610358199 , 1-59259-851-X
    Series Statement: Cancer drug discovery and development
    Content: Cell death, or apoptosis, plays an important role in biological processes and disease and offers special opportunities to develop new therapies for cancer, autoimmune disease, stroke, heart attack, and Alzheimer's disease. In Death Receptors in Cancer Therapy, leading physician-scientists and basic researchers review in depth our latest understanding of the molecular events that regulate cell death, illuminating those molecules that provide targets for agonists or antagonists designed to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particlar interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands. Authoritative and up-to-date, Death Receptors in Cancer Therapy offers a timely compendium of cell death signaling pathways for those seeking either a basic understanding of apoptosis or the knowledge needed to develop new therapeutics that will activate or block death signaling in disease.
    Note: Description based upon print version of record. , Mammalian Cell Death Pathways -- Resistance to Apoptosis in Cancer Therapy -- Structures of TNF Receptors and Their Interactions With Ligands -- Death Receptor Signaling in Embryonic Ectodermal Development -- Adaptor Proteins in Death Receptor Signaling -- Caspase Activation by the Extrinsic Pathway -- Death Signaling and Therapeutic Applications of TRAIL -- Death Receptor Mutations -- Regulation of Death Receptors -- Regulation of Trail Receptor Expression in Human Melanoma -- Regulation of Death Receptors by Synthetic Retinoids -- Role of p53 in Regulation of Death Receptors -- Proapoptotic Gene Silencing Via Methylation in Human Tumors -- Regulation of Death Receptor-Induced Apoptosis by NF-?B and Interferon Signaling Pathways -- TRAIL in Cancer Therapy -- Expression and Regulation of Death Receptors in Multiple Myeloma and Prostate Carcinoma -- Regulation of TRAIL-Induced Apoptosis by Transcriptional Factors -- Sensitizing Tumor Cells by Targeting Death Receptor Signaling Inhibitors -- Ceramide, Ceramidase, and FasL Gene Therapy in Prostate Cancer -- Gene Therapy Targeting Receptor-Mediated Cell Death to Cancers -- Combination of Chemotherapy and Death Ligands in Cancer Therapy. , English
    Additional Edition: ISBN 1-58829-172-3
    Language: English
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  • 10
    Online Resource
    Online Resource
    New York, NY : Springer
    UID:
    gbv_1652022880
    Format: Online-Ressource (VIII, 446 p. 22 illus., 21 illus. in color, digital)
    ISBN: 9781461461760 , 1283945894 , 9781283945899
    Series Statement: Advances in Experimental Medicine and Biology 779
    Content: ​​​The topic of ‘Impact of genetic targets on cancer therapy’ has reviews that each focuses on a specific tumor type, review recent knowledge about molecular pathogenesis in general and especially as it impacts response to therapy. The topic is aimed to provide a forum for publication of original peer-reviewed short communications, full-length research and review articles on new research findings and developments in cancer therapies. As the field is highly important it requires co-operation between research communities from all over the world to share their knowledge and experience in order to build a comprehensive knowledge on genetic targets on different cancer therapies. Each chapter also includes a discussion of the impact of the tumor microenvironment and cancer stem cells and cover current knowledge in this area as it pertains to the disease, including emerging therapy targeting the microenvironment and/or cancer stem cells
    Note: Description based upon print version of record , Impact of Genetic Targetson Cancer Therapy; Forward; Contents; Novel Antineoplastics Targeting Genetic Changes in Colorectal Cancer; Introduction; Overview of Genetic Alterations in Colorectal Cancer; Targeting Cell Death Pathways; Agonistic TRAIL Death Receptor Antibodies; Bcl-2; Targeting Growth Factor Signaling; The EGFR Family; IGF Receptors; Hepatocyte Growth Factor (HGF); Mutant BRAF; MEK; Akt; Mammalian Target of Rapamycin (mTOR); Protein Kinase C (PKC); Targeting Angiogenesis; VEGF Receptors; Other Receptors That Mediate Angiogenesis; Multi-Targeted Agents; Sorafenib; Sunitinib , DasatinibHarnessing the Immune System; Epithelial Cell Adhesion Molecule (EpCAM); Toll-Like Receptor 9 (TLR9); A33; Other Approaches; Wnt and Hedgehog Signaling Pathways; COX-2; Heat Shock Protein 90 (Hsp90); Virotherapy; Colorectal Cancer Stem Cells (CRCSCs); Stem Cell Signaling in CRC; Stem Cell Microenvironment in CRC; References; Update on Clinical Trials: Genetic Targets in Breast Cancer; Cell Membrane Signaling; Growth Factor Receptors EGFR and HER2- neu as Molecular Targets in Breast Cancer; IGF in Breast Cancer; Impact of the Tumor Microenvironment and Cancer Stem Cells , Cancer Stem Cells and Stem Cell Niche in Breast CancerAngiogenic Targets; Intracellular Signaling and Genetic, Epigenetic Targets; Intracellular Signaling; Ras, Raf, mTOR; Post-Translational Modi fi cation: Histone Deacytelase Inhibitors (HDACIs); MicroRNAs and the Molecular Pathogenesis of Breast Cancer; Telomerase Inhibitors in Breast Cancer; PARP in Breast Cancer; Hormone Receptor Positive but Resistant to Hormone Therapy; Mechanisms of Hormone Resistance; Conclusion; References; Impact of Genetic Targets on Cancer Therapy in Esophagogastric Cancer; Introduction , Targeting Epidermal Growth Factor Receptor (EGFR) Family PathwayTargeting Angiogenesis Pathway; Other Potential Targets; Conclusions; References; Impact of Genetic Targets on Cancer Therapy: Hepatocellular Cancer; Introduction; Pathogenesis and Genetics for HCC; Hepatitis Virus Infections and HCC; Sorafenib and Targeted Therapy for HCC; Types of Targeted Therapies; Tyrosine Kinase Inhibitors TKIs; Monoclonal Antibodies (mABs); Enzyme Inhibitors; Miscellaneous Agents; Combination Therapy and Future Directions; Cancer Stem Cells and New Targets in HCC; Conclusion; References , Toward the Goal of Personalized Therapy in Pancreatic Cancer by Targeting the Molecular PhenotypeIntroduction; Genetic Alterations Involved in Pathogenesis of Pancreatic Adenocarcinoma; Genetic Alterations as Therapeutic Targets; Receptor Tyrosine Kinases and Ligands; Epidermal Growth Factor (EGF); Insulin-Like Growth Factor-1 (IGF-1); Hepatocyte Growth Factor (HGF); Signal Transducers; RAS; MEK; AKT; Mammalian Target of Rapamycin (mTOR); Heat Shock Protein (Hsp90); Nuclear Targets; Histone Deacetylases (HDACs); Polo-Like Kinase 1 (Plk1); Ribonucleotide Reductase (RR) , Peroxisome Proliferator-Activated Receptor g (PPAR g) , ​​​Novel antineoplastics targeting genetic changes in colorectal cancer -- Update on Clinical Trials: Genetic Targets in Breast Cancer -- Impact of Genetic Targets on Cancer Therapy in Esophagogastric Cancer -- Impact of Genetic Targets on Cancer Therapy: Liver Cancer -- Targeting the molecular phenotype of pancreatic cancer toward the goal of patient-tailored therapy -- Impact of genetic markers on treatment of Non-small cell lung cancer -- Impact of Genetic Targets on Therapy in Head and Neck Squamous Cell Carcinoma -- Tyrosine Kinase Targeted Treatment of Chronic Myelogenous Leukemia and Other Myeloproliferative Neoplasms -- Targeted Therapy of Multiple Myeloma -- Current and Future Trials of Targeted Therapies in Cutaneous Melanoma -- Current Approaches to Epigenetic therapy for the treatment of Mantle Cell Lymphoma -- Impact of Genetic Targets on Primary Brain Tumor Therapy: What’s Ready for Prime Time? -- Rational therapy for renal cell carcinoma based on its genetic targets -- Molecular and Genetic Markers of Follicular-Cell Thyroid Cancer: Etiology and Diagnostic and Therapeutic Opportunities -- Genetic Targets in Pediatric Acute Lymphoblastic Leukemia -- Emerging molecular therapies for the treatment of Acute Lymphoblastic Leukemia -- Impact of Genetic Targets on Prostate Cancer Therapy -- Small-Cell Lung Cancer: An Update on Targeted Therapies -- Impact of Genetic Targets on Cancer Therapy in Acute Myelogenous Leukemia -- Index.
    Additional Edition: ISBN 9781461461753
    Additional Edition: Buchausg. u.d.T. ISBN 978-1-461-46175-3
    Language: English
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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