Umfang:
1 Online-Ressource (xiii, 488 Seiten)
,
Illustrationen, Diagramme
Ausgabe:
Second, completely revised and enlarged edition
ISBN:
9783527675661
,
9783527675678
,
9783527675685
Inhalt:
This advanced textbook is tailored for an introductory course in Systems Biology and is well-suited for biologists as well as engineers and computer scientists. It comes with student-friendly reading lists and a companion website featuring a short exam prep version of the book and educational modeling programs. The text is written in an easily accessible style and includes numerous worked examples and study questions in each chapter. For this edition, a section on medical systems biology has been included.
Inhalt:
Title Page -- Copyright -- Preface -- Guide to Different Topics of the Book -- About the Authors -- Part One: Introduction to Systems Biology -- 1: Introduction -- 1.1 Biology in Time and Space -- 1.2 Models and Modeling -- 1.2.1 What Is a Model? -- 1.2.2 Purpose and Adequateness of Models -- 1.2.3 Advantages of Computational Modeling -- 1.3 Basic Notions for Computational Models -- 1.3.1 Model Scope -- 1.3.2 Model Statements -- 1.3.3 System State -- 1.3.4 Variables, Parameters, and Constants -- 1.3.5 Model Behavior -- 1.3.6 Model Classification -- 1.3.7 Steady States
Inhalt:
1.3.8 Model Assignment is Not Unique -- 1.4 Networks -- 1.5 Data Integration -- 1.6 Standards -- 1.7 Model Organisms -- 1.7.1 Escherichia Coli -- 1.7.2 Saccharomyces Cerevisiae -- 1.7.3 Caenorhabditis Elegans -- 1.7.4 Drosophila Melanogaster -- 1.7.5 Mus Musculus -- References -- Further Reading -- 2: Modeling of Biochemical Systems -- 2.1 Overview of Common Modeling Approaches for Biochemical Systems -- 2.2 ODE Systems for Biochemical Networks -- 2.2.1 Basic Components of ODE Models -- 2.2.2 Illustrative Examples of ODE Models -- References -- Further Reading
Inhalt:
3: Structural Modeling and Analysis of Biochemical Networks -- 3.1 Structural Analysis of Biochemical Systems -- 3.1.1 System Equations -- 3.1.2 Information Encoded in the Stoichiometric Matrix N -- 3.1.3 The Flux Cone -- 3.1.4 Elementary Flux Modes and Extreme Pathways -- 3.1.5 Conservation Relations - Null Space of NT -- 3.2 Constraint-Based Flux Optimization -- 3.2.1 Flux Balance Analysis -- 3.2.2 Geometric Interpretation of Flux Balance Analysis -- 3.2.3 Thermodynamic Constraints -- 3.2.4 Applications and Tests of the Flux Optimization Paradigm -- 3.2.5 Extensions of Flux Balance Analysis
Inhalt:
Exercises -- References -- Further Reading -- 4: Kinetic Models of Biochemical Networks: Introduction -- 4.1 Reaction Kinetics and Thermodynamics -- 4.1.1 Kinetic Modeling of Enzymatic Reactions -- 4.1.2 The Law of Mass Action -- 4.1.3 Reaction Thermodynamics -- 4.1.4 Michaelis-Menten Kinetics -- 4.1.5 Regulation of Enzyme Activity by Effectors -- 4.1.6 Generalized Mass Action Kinetics -- 4.1.7 Approximate Kinetic Formats -- 4.1.8 Convenience Kinetics and Modular Rate Laws -- 4.2 Metabolic Control Analysis -- 4.2.1 The Coefficients of Control Analysis
Inhalt:
4.2.2 The Theorems of Metabolic Control Theory -- 4.2.3 Matrix Expressions for Control Coefficients -- 4.2.4 Upper Glycolysis as Realistic Model Example -- 4.2.5 Time-Dependent Response Coefficients -- Exercises -- References -- Further Reading -- 5: Data Formats, Simulation Techniques, and Modeling Tools -- 5.1 Simulation Techniques and Tools -- 5.1.1 Differential Equations -- 5.1.2 Stochastic Simulations -- 5.1.3 Simulation Tools -- 5.2 Standards and Formats for Systems Biology -- 5.2.1 Systems Biology Markup Language -- 5.2.2 BioPAX -- 5.2.3 Systems Biology Graphical Notation
Inhalt:
5.3 Data Resources for Modeling of Cellular Reaction Systems
Anmerkung:
Description based upon print version of record
Weitere Ausg.:
ISBN 9783527675678
Weitere Ausg.:
ISBN 9783527336364
Weitere Ausg.:
Erscheint auch als Druck-Ausgabe Klipp, Edda, 1965 - Systems biology Weinheim : Wiley-VCH Verlag GmbH & Co. KGaA, 2016 ISBN 3527336362
Weitere Ausg.:
ISBN 9783527336364
Sprache:
Englisch
Fachgebiete:
Biologie
Schlagwort(e):
Systembiologie
;
Electronic books
Mehr zum Autor:
Liebermeister, Wolfram 1972-
Mehr zum Autor:
Wierling, Christoph 1973-
Mehr zum Autor:
Klipp, Edda 1965-
Mehr zum Autor:
Kowald, Axel 1962-
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