Umfang:
6
,
Illustrationen
ISSN:
1573-7241
Inhalt:
Purpose - PERFORM is exploring the efficacy of terutroban versus aspirin for secondary prevention in patients with a history of ischemic stroke or transient ischemic attacks (TIAs). The PERFORM Vascular Project will evaluate the effect of terutroban on progression of atherosclerosis, as assessed by change in carotid intima-media thickness (CIMT) in a subgroup of patients. - - Methods and results - The Vascular Project includes structural (CIMT, carotid plaques) and functional (carotid stiffness) vascular studies in all patients showing at least one carotid plaque at entry. Expected mean follow-up is 36 months. Primary endpoint is rate of change of CIMT. Secondary endpoints include emergent plaques and assessment of carotid stiffness. 1,100 patients are required for 90% statistical power to detect treatment-related CIMT difference of 0.025 mm. The first patient was randomized in April 2006. - - Conclusions - The PERFORM Vascular Project will investigate terutroban’s effect on vascular structure and function in patients with a history of ischemic stroke or TIAs.
Anmerkung:
Gesehen am 12.03.2021
In:
Cardiovascular drugs and therapy, Dordrecht [u.a.] : Springer Science + Business Media B.V, 1987, 24(2010), 2, Seite 175-180, 1573-7241
In:
volume:24
In:
year:2010
In:
number:2
In:
pages:175-180
In:
extent:6
Sprache:
Englisch
DOI:
10.1007/s10557-010-6231-2
URL:
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