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  • English  (277)
  • 11
    UID:
    (DE-602)b3kat_BV036069355
    Format: 1 Online-Ressource (XI, 221 Seiten) , Illustrationen, Diagramme
    Edition: 2nd, revised and extended edition
    ISBN: 9783318010329
    Series Statement: Contributions to microbiology Vol. 11
    Content: This second, completely revised and extended edition of 〈i〉Prions: A Challenge for Science, Medicine and the Public Health System〈/i〉 is a comprehensive, up-to-date review of prions and prion-associated diseases. Leading scientists discuss the structure, molecular biology and origin of prions as well as strain variations and species barriers. Human prion diseases, prion inactivation and risks to public health are considered in detail. The new edition provides an update on basic findings of the last three years since publication of the previous edition and emphasizes practical aspects of fighting human and animal prion diseases. In addition, chapters on regulatory aspects of BSE and CJD as well as on veterinary measures have been included.A valuable single source of information on what is currently known about prions, this book will be of interest to any scientist or clinician who wants to keep up with the latest developments in this fast-moving field
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-8055-7656-7
    Language: English
    Subjects: Medicine
    RVK:
    RVK:
    Keywords: Prion ; Spongiöse subakute Encephalopathie ; Jakob-Creutzfeldt-Syndrom ; Prionkrankheit ; Aufsatzsammlung
    URL: Volltext  (Deutschlandweit zugänglich)
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  • 12
    UID:
    (DE-627)32118999X
    Format: VIII, 164 S. , Ill., graph. Darst. , 25 cm
    ISBN: 3805571240
    Series Statement: Contributions to microbiology 7
    Note: Includes bibliographical references and indexes
    Language: English
    Subjects: Medicine
    RVK:
    Keywords: Prion ; Spongiöse subakute Encephalopathie ; Jakob-Creutzfeldt-Syndrom ; Prion ; Spongiöse subakute Encephalopathie ; Jakob-Creutzfeldt-Syndrom ; Aufsatzsammlung
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  • 13
    UID:
    (DE-603)366632051
    Format: Online-Ressource
    ISSN: 1756-0500
    Content: Background: Different flavonoids are known to interfere with influenza A virus replication. Recently, we showed that the structurally similar flavonoids baicalein and biochanin A inhibit highly pathogenic avian H5N1 influenza A virus replication by different mechanisms in A549 lung cells. Here, we investigated the effects of both compounds on H5N1-induced reactive oxygen species (ROS) formation and the role of ROS formation during H5N1 replication. ...
    In: Biomed Central (London), BMC Research Notes, London, 2008-, Band 7, Heft 384 (2014), 1756-0500
    In: volume:7
    In: year:2014
    In: number:384
    In: extent:6
    Language: English
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  • 14
    UID:
    (DE-604)BV036069355
    Format: 1 Online-Ressource (XI, 221 Seiten) , Illustrationen, Diagramme
    Edition: 2nd, revised and extended edition
    ISBN: 9783318010329
    Series Statement: Contributions to microbiology Vol. 11
    Content: This second, completely revised and extended edition of 〈i〉Prions: A Challenge for Science, Medicine and the Public Health System〈/i〉 is a comprehensive, up-to-date review of prions and prion-associated diseases. Leading scientists discuss the structure, molecular biology and origin of prions as well as strain variations and species barriers. Human prion diseases, prion inactivation and risks to public health are considered in detail. The new edition provides an update on basic findings of the last three years since publication of the previous edition and emphasizes practical aspects of fighting human and animal prion diseases. In addition, chapters on regulatory aspects of BSE and CJD as well as on veterinary measures have been included.A valuable single source of information on what is currently known about prions, this book will be of interest to any scientist or clinician who wants to keep up with the latest developments in this fast-moving field
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-8055-7656-7
    Language: English
    Subjects: Medicine
    RVK:
    RVK:
    Keywords: Prion ; Spongiöse subakute Encephalopathie ; Jakob-Creutzfeldt-Syndrom ; Prionkrankheit ; Aufsatzsammlung
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  • 15
    Online Resource
    Online Resource
    Basingstoke : Stockton Press | Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg
    UID:
    (DE-603)51428157X
    Format: 1 Online-Ressource (9 Seiten)
    Content: Although human cytomegalovirus (HCMV) is generally not regarded to be an oncogenic virus, HCMV infection has been implicated in malignant diseases from different cancer entities. On the basis of our experimental findings, we developed the concept of “oncomodulation” to better explain the role of HCMV in cancer. Oncomodulation means that HCMV infects tumor cells and increases their malignancy. By this concept, HCMV was proposed to be a therapeutic target in a fraction of cancer patients. However, the clinical relevance of HCMV-induced oncomodulation remains to be clarified. One central question that has to be definitively answered is if HCMV establishes persistent virus replication in tumor cells or not. In our eyes, recent clinical findings from different groups in glioblastoma patients and especially the detection of a correlation between the numbers of HCMV-infected glioblastoma cells and tumor stage (malignancy) strongly increase the evidence that HCMV may exert oncomodulatory effects. Here, we summarize the currently available knowledge about the molecular mechanisms that may contribute to oncomodulation by HCMV as well as the clinical findings that suggest that a fraction of tumors from different entities is indeed infected with HCMV.
    Additional Information: Enthalten in Neoplasia. Jahrgang 11, Heft 1
    Language: English
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  • 16
    UID:
    (DE-627)1805909223
    Format: 1 Online-Ressource (viii, 164 pages) , illustrations
    ISBN: 0585440565 , 9780585440569
    Series Statement: Contributions to microbiology vol. 7
    Content: In the past decades, the public has been forced to revise its perception of the apparent triumph of modern hygiene and medical microbiology over infectious diseases. Not only have older infections reemerged but new epidemics, like AIDS, have lead to public uncertainty. With the onset of the bovine spongiform encephalopathy epidemic in Great Britain, novel infectious agents came into the public spotlight, ones that do not cause classical inflammation but a slow and irreversible degeneration of the central nervous system. Sensational from a scientific point of view, these agents, called proteinaceous infectious organisms or prions, were shown to be self-replicating without nucleic acid sequences to encode genomic information.In this volume, leading scientists deal with the medical, scientific and public health questions that prion infections raise. Besides the 'prion or virus' discussion, the structures of prions and their molecular biological analysis as well as the questions of strain variations and species barrier are presented. The etiological, clinical and diagnostic aspects of transmissible spongiform encephalopathies are given special attention. The epidemiology of human and animal prion diseases, disease management and possibilities for inactivation of prions are discussed from a public health perspective. Directed at scientists, physicians and the public health sector, the monograph uses a multidisciplinary approach to present the latest findings on prion infection
    Note: Includes bibliographical references and indexes
    Additional Edition: 9783318006223
    Additional Edition: 331800622X
    Additional Edition: 3805571240
    Additional Edition: Erscheint auch als Druck-Ausgabe Prions Basel ; New York : Karger, ©2001
    Language: English
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  • 17
    UID:
    (DE-603)428660002
    ISSN: 1523-5866
    In: Neuro-Oncology, Oxford : Oxford Univ. Press, 1999-, Band 17, Heft 7 (2014), Seite 1039-1039, 1523-5866
    In: volume:17
    In: year:2014
    In: number:7
    In: pages:1039-1039
    In: extent:1
    Language: English
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  • 18
    UID:
    (DE-604)BV048279150
    Format: 1 Online-Ressource (viii, 164 Seiten) , illustrations
    ISBN: 0585440565 , 331800622X , 9780585440569 , 9783318006223
    Series Statement: Contributions to microbiology vol. 7
    Content: In the past decades, the public has been forced to revise its perception of the apparent triumph of modern hygiene and medical microbiology over infectious diseases. Not only have older infections reemerged but new epidemics, like AIDS, have lead to public uncertainty. With the onset of the bovine spongiform encephalopathy epidemic in Great Britain, novel infectious agents came into the public spotlight, ones that do not cause classical inflammation but a slow and irreversible degeneration of the central nervous system. Sensational from a scientific point of view, these agents, called proteinaceous infectious organisms or prions, were shown to be self-replicating without nucleic acid sequences to encode genomic information.In this volume, leading scientists deal with the medical, scientific and public health questions that prion infections raise. Besides the 'prion or virus' discussion, the structures of prions and their molecular biological analysis as well as the questions of strain variations and species barrier are presented. The etiological, clinical and diagnostic aspects of transmissible spongiform encephalopathies are given special attention. The epidemiology of human and animal prion diseases, disease management and possibilities for inactivation of prions are discussed from a public health perspective. Directed at scientists, physicians and the public health sector, the monograph uses a multidisciplinary approach to present the latest findings on prion infection
    Additional Edition: Erscheint auch als Druck-Ausgabe Prions Basel ; New York : Karger, ©2001 ISBN 3805571240
    Language: English
    Subjects: Medicine
    RVK:
    Keywords: Prion ; Jakob-Creutzfeldt-Syndrom ; Prionkrankheit ; Spongiöse subakute Encephalopathie ; Aufsatzsammlung
    URL: Volltext  (kostenfrei)
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  • 19
    UID:
    (DE-627)80116012X
    Format: Online-Ressource (xi, 221 p) , ill
    Edition: 2nd, rev. and extended ed
    Edition: Online-Ausg.
    ISBN: 1417522569 , 9781417522569
    Series Statement: Contributions to microbiology v. 11
    Note: Includes bibliographical references and index , ""Contents""; ""Dedication in Remembrance of Andreas Scheid (1941�2001)""; ""Note of the Series Editor""; ""Preface to the Second Edition""; ""Preface to the First Edition""; ""Transmissible Spongiform Encephalopathies: The Prion Theory � Background and Basic Information""; ""Non-Virus Properties of the Scrapie Agent""; ""The Concept of Two Isoforms of the Prion Protein""; ""Basic Experiments Pro and Contra Prions""; ""The Search for a Nucleic Acid""; ""Structural Transitions of the Prion Protein as Basis for the Replication Mechanism"" , ""Infectious, Sporadic and Familial Etiology of Prion Diseases Based on the Prion Model""""Outlook""; ""Acknowledgment""; ""References""; ""Structural Biology of Prions""; ""The Primary Structure of the Prion Protein""; ""The Neurotoxic Model Peptide, PrP106�126""; ""Metal-Binding Domains of the Prion Protein""; ""Secondary Structure Analysis of the Prion Protein""; ""Tertiary Structure of the Normal Prion Protein (PrPC)""; ""Influence of Familial Mutations on the Structure of the Prion Protein""; ""Tertiary Structure of the Infectious Prion Protein (PrP TSE )"" , ""Deciphering the Structure of Infectious Prion Protein with Antibodies""""Prion Protein Folding Pathways and Their Conformational Properties""; ""Conclusion""; ""References""; ""Prion Strains and Species Barriers""; ""Prion Strains""; ""Molecular Basis of Prion Strains""; ""Species Barriers""; ""Subclinical Prion Infection""; ""Implications of Prion Disease vs. Prion Infection""; ""Re-Evaluating Prion Strains and Species Barriers""; ""Acknowledgement""; ""References""; ""Prions of Saccharomyces and Podospora""; ""Three Genetic Criteria for Prions""; ""[URE3] as a Prion of the Ure2 Protein"" , ""Structure of Ure2p""""Aggregation of Ure2p in vivo and in vitro""; ""[PSI] as a Prion of the Sup35 Protein""; ""Interaction with Other Proteins in the Cell and Influence of Chaperones""; ""Prion Variants""; ""Other Prions in Saccharomyces cerevisiae""; ""[Het-s], a Prion with a Normal Cellular Function""; ""Are in vitro Produced Filaments Infectious?""; ""Acknowledgement""; ""References""; ""Human Prion Diseases: Cause, Clinical and Diagnostic Aspects""; ""Creutzfeldt-Jakob Disease""; ""Sporadic CJD (spCJD)""; ""Epidemiology and Cause""; ""Clinical Features""; ""Diagnosis"" , ""Iatrogenic (iCJD)""""Epidemiology and Cause""; ""Clinical Features""; ""Diagnosis""; ""Variant (vCJD)""; ""Epidemiology and Cause""; ""Clinical Features""; ""Diagnosis""; ""Genetic (gCJD)""; ""Epidemiology and Cause""; ""Clinical Features""; ""Diagnosis""; ""Gerstmann-Str�ussler-Scheinker Syndrome (GSS)""; ""Epidemiology and Cause""; ""Clinical Features""; ""Diagnosis""; ""Fatal Familial Insomnia""; ""Epidemiology and Cause""; ""Clinical""; ""Diagnosis""; ""Kuru""; ""Epidemiology and Cause""; ""Clinical Features""; ""Diagnosis""; ""References"" , ""Epidemiology and Risk Factors of Transmissible Spongiform Encephalopathies in Man""
    Additional Edition: 3805576560
    Additional Edition: Print version Prions
    Language: English
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  • 20
    UID:
    (DE-604)BV036069070
    Format: 1 Online-Ressource (XII, 308 Seiten) , Illustrationen, Diagramme
    ISBN: 9783318002621
    Series Statement: Monographs in virology Vol. 21
    Content: Cytomegalovirus (CMV) infection can cause severe diseases with significant morbidity and mortality in immunocompromised patients such as bone marrow or solid-organ transplant recipients, and AIDS patients. Major manifestations include transplant rejection, hepatitis, pneumonitis, encephalitis and retinitis. There is growing evidence that in certain cases CMV disease is closely linked to aberrant immune responses occurring locally within the respective tissues.This book provides important new insights into CMV-related immunopathology, discusses current methods of CMV diagnosis and anti-CMV therapy, and proposes novel antiviral treatment strategies. It contains contributions by leading scientists and clinicians in the field of CMV, who participated in the 'First International Round Table Consensus Meeting', held in Frankfurt, Germany, in August 1997. Comprehensive and up-to-date, this volume is a vital reference for clinicians involved in the diagnosis and treatment of CMV infections, as well as for researchers working on herpesvirus biology and the development of antiviral drugs
    Note: 1st International Consensus Round Table Meeting, Frankfurt, August 1997 ; expert reviews on current and future anti-CMV treatment strategies
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-8055-6602-5
    Language: English
    Subjects: Medicine
    RVK:
    RVK:
    Keywords: Cytomegalie-Virus ; Infektion ; Immunpathologie ; Cytomegalie ; Konferenzschrift
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