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Berlin Brandenburg

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  • MEDLINE/PubMed (NLM)  (111)
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  • 11
    In: Infection and Immunity, 1999, Vol. 67(5), p.2649
    Description: We developed an enzyme-linked immunosorbent assay-based assay to assess Haemophilus ducreyi binding to extracellular matrix (ECM) proteins. H. ducreyi 35000HP bound to fibronectin, laminin, and type I and III collagen but not to type IV, V, or VI collagen or elastin. Isogenic strains with mutations in ftpA or losB bound as well as the parent, suggesting that neither pili nor full-length lipooligosaccharide is required for H. ducreyi to bind to ECM proteins.
    Keywords: Medicine ; Biology;
    ISSN: 0019-9567
    ISSN: 00199567
    E-ISSN: 10985522
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  • 12
    Language: English
    In: Psychological Assessment, 2013, Vol.25(3), pp.1037-1043
    Description: Most research on posttraumatic stress disorder (PTSD) relies on clinician-administered interview and self-report measures to establish the presence/absence and severity of the disorder. Accurate diagnosis of PTSD is made challenging by the presence of symptoms shared with other psychopathologies and the subjective nature of patients’ descriptions of their symptoms. A physiological assessment capable of reliably “diagnosing” PTSD could provide adjunctive information that might mitigate these diagnostic limitations. In the present study, we examined the construct validity of a potential psychophysiological measure of PTSD, that is, psychophysiological reactivity to script-driven imagery (SDI–PR), as measured against the current diagnostic “gold-standard” for PTSD, the Clinician-Administered PTSD Scale (CAPS). Convergent and predictive validity and stability were examined. Thirty-six individuals completed an SDI–PR procedure, the CAPS, and self-report measures of mental and physical health at their initial visit and approximately 6 months later. SDI–PR and the CAPS demonstrated excellent stability across measurement occasions. SDI–PR showed moderately strong convergent validity with the CAPS. After adjusting for self-reported depression, predictive validity for the CAPS, with regard to health sequelae, was reduced, whereas it remained mostly unchanged for SDI–PR. Findings support SDI–PR as a valid and stable measure of PTSD that captures a pathophysiologic process in individuals with PTSD. Results are discussed with regard to the research domain criteria framework.
    Keywords: Posttraumatic Stress Disorder ; Ptsd ; Psychophysiology ; Reliability ; Depression
    ISSN: 1040-3590
    E-ISSN: 1939-134X
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  • 13
    Language: English
    In: The Journal of infectious diseases, 01 March 2009, Vol.199(5), pp.684-92
    Description: A gene expression study of Haemophilus ducreyi identified the hypothetical lipoprotein HD0192, renamed here "fibrinogen binder A" (FgbA), as being preferentially expressed in vivo. To test the role played by fgbA in virulence, an isogenic fgbA mutant (35000HPfgbA) was constructed using H. ducreyi 35000HP, and 6 volunteers were experimentally infected with 35000HP or 35000HPfgbA. The overall pustule-formation rate was 61.1% at parent sites and 22.2% at mutant sites (P = .019). Papules were significantly smaller at mutant sites than at parent sites (13.3 vs. 37.9 mm(2); P = .002) 24 h after inoculation. Thus, fgbA contributed significantly to the virulence of H. ducreyi in humans. In vitro experiments demonstrated that fgbA encodes a fibrinogen-binding protein; no other fibrinogen-binding proteins were identified in 35000HP. fgbA was conserved among clinical isolates of both class I and II H. ducreyi strains, supporting the finding that fgbA is important for H. ducreyi infection.
    Keywords: Bacterial Proteins -- Metabolism ; Chancroid -- Microbiology ; Fibrinogen -- Metabolism ; Haemophilus Ducreyi -- Genetics ; Lipoproteins -- Metabolism
    ISSN: 0022-1899
    E-ISSN: 15376613
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  • 14
    In: Infection and Immunity, 2002, Vol. 70(4), p.1667
    Keywords: Animals–Etiology ; Chancroid–Immunology ; Disease Models, Animal–Pathology ; Haemophilus Ducreyi–Immunology ; Humans–Pathogenicity ; Interferon-Gamma–Biosynthesis ; Macrophages–Immunology ; Neutrophils–Immunology ; Proteins–Biosynthesis ; Rabbits–Biosynthesis ; Tumor Necrosis Factor-Alpha–Biosynthesis ; Virulence–Biosynthesis ; Proteins ; Tumor Necrosis Factor-Alpha ; Interferon-Induced 56k Protein, Human ; Interferon-Gamma;
    ISSN: 0019-9567
    ISSN: 00199567
    E-ISSN: 10985522
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  • 15
    In: Infection and Immunity, 2001, Vol. 69(4), p.2549
    Description: In a previous study, Haemophilus ducreyi was found in the pustule and dermis of samples obtained at the clinical end point in the human model of infection. To understand the kinetics of localization, we examined infected sites at 0, 24, and 48 h after inoculation and at the clinical end point. Immediately after inoculation, bacteria were found predominantly in the dermis but also in the epidermis. Few bacteria were detectable at 24 h; however, by 48 h, bacteria were readily seen in the pustule and dermis. H. ducreyi was associated with polymorphonuclear leukocytes and macrophages in the pustule and at its base, but was not associated with T cells, Langerhans' cells, or fibroblasts. H. ducreyi colocalized with collagen and fibrin but not laminin or fibronectin. Association with phagocytes, collagen, and fibrin was seen as early as 48 h and persisted at the pustular stage of disease. Optical sectioning by confocal microscopy and transmission electron microscopy both failed to demonstrate intracellular H. ducreyi. These data identify collagen and fibrin as potentially important targets of adherence in vivo and strongly suggest that H. ducreyi remains extracellular throughout infection and survives by resisting phagocytic killing in vivo.
    Keywords: Bacterial Adhesion ; Collagen -- Physiology ; Fibrin -- Physiology ; Haemophilus Ducreyi -- Physiology ; Phagocytes -- Microbiology;
    ISSN: 0019-9567
    ISSN: 00199567
    E-ISSN: 10985522
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  • 16
    In: Antimicrobial Agents and Chemotherapy, 2007, Vol. 51(9), p.3391
    Description: We examined the susceptibility of Haemophilus ducreyi to antimicrobial peptides likely to be encountered in vivo during human infection. H. ducreyi was significantly more resistant than Escherichia coli to the bactericidal effects of all peptides tested. Class I and II H. ducreyi strains exhibited similar levels of resistance to antimicrobial peptides.
    Keywords: Anti-Bacterial Agents -- Pharmacology ; Defensins -- Pharmacology ; Haemophilus Ducreyi -- Drug Effects ; Peptides -- Pharmacology;
    ISSN: 0066-4804
    ISSN: 00664804
    E-ISSN: 10986596
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  • 17
    Language: English
    In: Health Psychology, 2016, Vol.35(6), pp.584-593
    Description: Objective: Coping processes directed toward avoiding and approaching stressor-related thoughts and emotions predict psychological adjustment. However, few studies have examined how the relationship between dispositional emotional tendencies and stressor-specific coping affects outcomes. The aim of the current study was to examine the association of dispositional emotional expressivity (i.e., the propensity to experience and express emotions strongly) with cancer-specific coping through avoidance and emotional approach to predict intrusive thoughts and depressive symptoms in Latinas with breast cancer. Method: Recently diagnosed Latina breast cancer patients receiving treatment completed standardized assessments via interview at 2 time points: within 18 months of diagnosis (Time 1; N = 95) and 3 months later (Time 2; N = 79). Results: Most women were immigrants (93%), reported a combined household income of $20,000 or less (75%), did not graduate from high school (59%), and primarily spoke Spanish (88%). In path analyses, more recent immigration was associated with greater dispositional expressivity, which in turn was associated with coping with the cancer experience using both greater avoidance and emotional approach strategies. Only avoidance-oriented strategies predicted an increase in intrusive thoughts at 3 months. No significant effects on depressive symptoms were observed. Conclusions: Findings suggest that Latina breast cancer patients who have a propensity to experience and express emotions strongly may be initially overwhelmed by their cancer-related emotions and consequently turn to avoidance-oriented and emotional approach strategies to cope with their diagnosis. Avoidance-oriented coping in turn may uniquely predict an increase in cancer-related intrusive thoughts 3 months later.
    Keywords: Avoidance ; Approach ; Breast Cancer ; Coping ; Latina
    ISSN: 0278-6133
    E-ISSN: 1930-7810
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  • 18
    In: Proceedings of the National Academy of Sciences of the United States, March 14, 2000, Vol.97(6), p.2785
    Description: We are developing assays for noninvasive, quantitative imaging of reporter genes with positron emission tomography (PET), for application both in animal models and in human gene therapy. We report here a method to improve the detection of lower levels of PET reporter gene expression by utilizing a mutant herpes simplex virus type I thymidine kinase (HSV1-sr39tk) as a PET reporter gene. The HSV1-sr39tk mutant was identified from a library of site-directed mutants. Accumulation (net uptake) of the radioactively labeled substrates [8-[sup.3]H]penciclovir (8-[sup.3]H]PCV), and 8-[[sup.18]F]fluoro-penciclovir (FPCV) in C6 rat glioma cells expressing HSV1-sr39tk is increased by a factor of [approximately equals] 2.0 when compared with C6 cells expressing wild-type HSV1-tk. The increased imaging sensitivity of HSV1-sr39tk when FPCV is used is also demonstrated in vivo both with tumor cells stably transfected with either HSV1-tk or HSV1-sr39tk, and after hepatic delivery of HSV1-tk or HSV1-sr39tk by using adenoviral vectors. The use of HSV1-sr39tk as a PET reporter gene and FPCV as a PET reporter probe results in significantly enhanced sensitivity for imaging reporter gene expression in vivo.
    Keywords: Herpes Simplex Virus -- Genetic Aspects ; Positron Emission Tomography -- Usage ; Gene Therapy -- Research ; Gene Expression -- Analysis
    ISSN: 0027-8424
    E-ISSN: 10916490
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  • 19
    Language: English
    In: Journal of Behavioral Medicine, 2017, Vol.40(6), pp.875-885
    Description: Breast cancer patients often experience adverse physical side effects of medical treatments. According to the biobehavioral model of cancer stress and disease, life stress during diagnosis and treatment may negatively influence the trajectory of women’s physical health-related adjustment to breast cancer. This longitudinal study examined chronic and episodic stress as predictors of bothersome physical symptoms during the year after breast cancer diagnosis. Women diagnosed with breast cancer in the previous 4 months ( N  = 460) completed a life stress interview for contextual assessment of chronic and episodic stress severity at study entry and 9 months later. Physical symptom bother (e.g., pain, fatigue) was measured at study entry, every 6 weeks through 6 months, and at nine and 12 months. In multilevel structural equation modeling (MSEM) analyses, both chronic stress and episodic stress occurring shortly after diagnosis predicted greater physical symptom bother over the study period. Episodic stress reported to have occurred prior to diagnosis did not predict symptom bother in MSEM analyses, and the interaction between chronic and episodic stress on symptom bother was not significant. Results suggest that ongoing chronic stress and episodic stress occurring shortly after breast cancer diagnosis are important predictors of bothersome symptoms during and after cancer treatment. Screening for chronic stress and recent stressful life events in the months following diagnosis may help to identify breast cancer patients at risk for persistent and bothersome physical symptoms. Interventions to prevent or ameliorate treatment-related physical symptoms may confer added benefit by addressing ongoing non-cancer-related stress in women’s lives.
    Keywords: Stress ; Life events ; Breast cancer ; Physical symptoms ; Survivorship
    ISSN: 0160-7715
    E-ISSN: 1573-3521
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  • 20
    Language: English
    In: Annals of Behavioral Medicine, 2016, Vol.50(3), pp.370-384
    Description: BACKGROUND: Few studies examine whether dispositional approach and avoidance coping and stressor-specific coping strategies differentially predict physical adjustment to cancer-related stress.PURPOSE: This study examines dispositional and situational avoidance and approach coping as unique predictors of the bother women experience from physical symptoms after breast cancer treatment, as well as whether situational coping mediates the prediction of bother from physical symptoms by dispositional coping.METHOD: Breast cancer patients (N = 460) diagnosed within the past 3months completed self-report measures of dispositional coping at study entry and of situational coping and bother from physical symptoms every 6weeks through 6months.RESULTS: In multilevel structural equation modeling analyses, both dispositional and situational avoidance predict greater symptom bother. Dispositional, but not situational, approach predicts less symptom bother. Supporting mediation models, dispositional avoidance predicts more symptom bother indirectly through greater situational avoidance. Dispositional approach predicts less symptom bother through less situational avoidance.CONCLUSION: Psychosocial interventions to reduce cancer-related avoidance coping are warranted for cancer survivors who are high in dispositional avoidance and/or low in dispositional approach.
    Keywords: Avoidance ; Approach ; Coping ; Breast cancer ; Physical symptoms
    ISSN: 0883-6612
    E-ISSN: 1532-4796
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