Kooperativer Bibliotheksverbund

Berlin Brandenburg

and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Journal of infectious diseases  (28)
Type of Medium
Language
Year
Journal
  • Journal of infectious diseases  (28)
  • 11
    Language: English
    In: The Journal of infectious diseases, 01 June 2008, Vol.197(11), pp.1531-6
    Description: Haemophilus ducreyi 35000HP contains a cluster of homologues of genes required for the synthesis of enterobacterial common antigen (ECA), suggesting that H. ducreyi may express a putative ECA-like glycoconjugate. WecA initiates the synthesis of ECA by transferring N-acetylglucosamine to undecaprenyl-P, to form lipid I. A wecA mutant (35000HPwecA) was constructed, and 5 volunteers were inoculated at 3 sites with fixed doses of 35000HP on one arm and at 3 sites with varying doses of 35000HPwecA on the other arm. 35000HPwecA caused pustules to form at 3 sites inoculated with a dose 2.5-fold higher than that of 35000HP. However, at sites inoculated with similar doses of 35000HP and 35000HPwecA, pustules developed at 46.7% (95% confidence interval [CI], 23.3%-70.0%) of 15 parent-strain sites and at 8.3% (95% CI, 0.01%-23.6%) of 12 mutant-strain sites (P = .013). Thus, the expression of wecA contributes to the ability of H. ducreyi to cause pustules in humans.
    Keywords: Multigene Family ; Antigens, Bacterial -- Genetics ; Chancroid -- Microbiology ; Haemophilus Ducreyi -- Genetics
    ISSN: 0022-1899
    E-ISSN: 15376613
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 12
    Language: English
    In: The Journal of Infectious Diseases, 1 February 1990, Vol.161(2), pp.336-339
    Description: The development of vaccines to prevent Neisseria infections has been impeded by antigenic diversity of most Neisseria surface components. The lipid-modified azurin (Laz), one of two distinct surface proteins recognized by the H.8 monoclonal antibody, is present in all pathogenic Neisseria. The mature protein has two domains; one contains an H.8 epitope and the other has extensive homology to azurins, a class of bacterial copper-binding proteins. The cellular location of Laz and the serum immune response to Laz were examined in patients with disseminated Neisseria infections. The data demonstrated that Laz is probably contained in the Neisseria outer membrane, although unlike most outer membrane proteins it is Sarkosyl soluble. By probing recombinant bacteriophages encoding the H.8 and azurin domains of Laz, results showed that whereas the H.8 epitope is immunogenic in patients with disseminated Neisseria infections, the azurin domain of Laz plays little role in eliciting an antibody response in these patients.
    Keywords: Biological sciences -- Biology -- Microbiology -- Epitopes ; Physical sciences -- Chemistry -- Chemical compounds -- Polyclonal antibodies ; Health sciences -- Medical conditions -- Infections -- Monoclonal antibodies ; Health sciences -- Medical sciences -- Immunology -- Monoclonal antibodies ; Health sciences -- Medical sciences -- Immunology -- Monoclonal antibodies ; Health sciences -- Medical sciences -- Immunology -- Monoclonal antibodies ; Physical sciences -- Astronomy -- Astronomical cosmology -- Monoclonal antibodies ; Physical sciences -- Chemistry -- Chemical compounds -- Monoclonal antibodies ; Health sciences -- Medical sciences -- Immunology -- Monoclonal antibodies ; Health sciences -- Medical sciences -- Immunology -- Monoclonal antibodies
    ISSN: 00221899
    E-ISSN: 15376613
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 13
    Language: English
    In: The Journal of Infectious Diseases, 1 February 1990, Vol.161(2), pp.336-339
    Description: The development of vaccines to prevent Neisseria infections has been impeded by antigenic diversity of most Neisseria surface components. The lipid-modified azurin (Laz), one of two distinct surface proteins recognized by the H.8 monoclonal antibody, is present in all pathogenic Neisseria. The mature protein has two domains; one contains an H.8 epitope and the other has extensive homology to azurins, a class of bacterial copper-binding proteins. The cellular location of Laz and the serum immune response to Laz were examined in patients with disseminated Neisseria infections. The data demonstrated that Laz is probably contained in the Neisseria outer membrane, although unlike most outer membrane proteins it is Sarkosyl soluble. By probing recombinant bacteriophages encoding the H.8 and azurin domains of Laz, results showed that whereas the H.8 epitope is immunogenic in patients with disseminated Neisseria infections, the azurin domain of Laz plays little role in eliciting an antibody response in these patients.
    ISSN: 00221899
    Source: Archival Journals (JSTOR)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 14
    Language: English
    In: The Journal of Infectious Diseases, 1 June 1997, Vol.175(6), pp.1390-1395
    Description: The performance of two EIAs (adsorption EIA and lipooligosaccharide [LOS] EIA) that detect antibodies to Haemophilus ducreyi was evaluated with serum specimens obtained from 163 patients (96 with genital ulcer disease [GUD]). Paired serum specimens (initial and follow-up) were obtained from 52 of the GUD patients. By use of initial serum specimens from 82 GUD patients whose etiologic agents for their ulcers had been identified, the adsorption EIA had a sensitivity and specificity for chancroid of 53% and 71%, while the LOS EIA had a sensitivity and specificity of 48% and 89%, respectively. Sensitivity and specificity of the adsorption EIA increased to 78% and 84%, respectively, when the results of follow-up serum specimens were used to calculate optimal performance. The proportion of patients testing positive for H. ducreyi who had anti-H. ducreyi IgG antibodies, as determined by adsorption EIA, increased with the duration of infection, thus limiting the role of EIAs in the diagnosis of chancroid.
    Keywords: Health sciences -- Medical conditions -- Physical trauma -- Haemophilus ducreyi ; Health sciences -- Medical conditions -- Infections -- Haemophilus ducreyi ; Physical sciences -- Chemistry -- Chemical reactions -- Haemophilus ducreyi ; Health sciences -- Medical sciences -- Immunology -- Haemophilus ducreyi ; Biological sciences -- Biology -- Microbiology -- Haemophilus ducreyi ; Health sciences -- Medical conditions -- Diseases -- Haemophilus ducreyi ; Biological sciences -- Biology -- Anatomy -- Haemophilus ducreyi ; Health sciences -- Medical conditions -- Infections -- Haemophilus ducreyi ; Health sciences -- Medical sciences -- Immunology -- Haemophilus ducreyi ; Physical sciences -- Earth sciences -- Geology -- Haemophilus ducreyi
    ISSN: 00221899
    E-ISSN: 15376613
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 15
    Language: English
    In: The Journal of infectious diseases, 15 May 2007, Vol.195(10), pp.1443-51
    Description: We infected 11 HIV-seropositive volunteers whose CD4(+) cell counts were 〉350 cells/ microL (7 of whom were receiving antiretrovirals) with Haemophilus ducreyi. The papule and pustule formation rates were similar to those observed in HIV-seronegative historical control subjects. No subject experienced a sustained change in CD4(+) cell count or HIV RNA level. The cellular infiltrate in biopsy samples obtained from the HIV-seropositive and HIV-seronegative subjects did not differ with respect to the percentage of leukocytes, neutrophils, macrophages, or T cells. The CD4(+):CD8(+) cell ratio in biopsy samples from the HIV-seropositive subjects was 1:3, the inverse of the ratio seen in the HIV-seronegative subjects (P〈.0001). Although CD4(+) cells proliferated in lesions, in situ hybridization and reverse-transcription polymerase chain reaction for HIV RNA was negative. We conclude that experimental infection in HIV-seropositive persons is clinically similar to infection in HIV-seronegative persons and does not cause local or augment systemic viral replication. Thus, prompt treatment of chancroid may abrogate increases in viral replication associated with natural disease.
    Keywords: Chancroid -- Complications ; HIV Infections -- Complications ; Haemophilus Ducreyi -- Physiology
    ISSN: 0022-1899
    E-ISSN: 15376613
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 16
    Language: English
    In: The Journal of Infectious Diseases, 1 June 1992, Vol.165, pp.S198-S199
    Keywords: Biological sciences -- Biology -- Microbiology -- Haemophilus ducreyi ; Health sciences -- Medical conditions -- Infections -- Haemophilus ducreyi ; Physical sciences -- Chemistry -- Chemical compounds -- Haemophilus ducreyi ; Health sciences -- Health and wellness -- Public health -- Haemophilus ducreyi ; Health sciences -- Medical conditions -- Infections -- Haemophilus ducreyi
    ISSN: 00221899
    Source: Archival Journals (JSTOR)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 17
    Language: English
    In: The Journal of Infectious Diseases, 1 June 1992, Vol.165, pp.S198-S199
    Keywords: Biological sciences -- Biology -- Microbiology -- Haemophilus ducreyi ; Health sciences -- Medical conditions -- Infections -- Haemophilus ducreyi ; Physical sciences -- Chemistry -- Chemical compounds -- Haemophilus ducreyi ; Health sciences -- Health and wellness -- Public health -- Haemophilus ducreyi ; Health sciences -- Medical conditions -- Infections -- Haemophilus ducreyi
    ISSN: 00221899
    Source: Archival Journals (JSTOR)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 18
    Language: English
    In: The Journal of Infectious Diseases, 1 June 1992, Vol.165, pp.S195-S196
    Keywords: Health sciences -- Medical sciences -- Immunology -- Epitopes ; Biological sciences -- Biology -- Genetics -- Monoclonal antibodies ; Health sciences -- Medical conditions -- Infections -- Monoclonal antibodies ; Health sciences -- Health and wellness -- Public health -- Monoclonal antibodies ; Biological sciences -- Biology -- Genetics -- Monoclonal antibodies ; Physical sciences -- Chemistry -- Chemical compounds -- Monoclonal antibodies ; Biological sciences -- Biology -- Microbiology -- Monoclonal antibodies ; Physical sciences -- Chemistry -- Chemical compounds -- Monoclonal antibodies ; Health sciences -- Medical sciences -- Immunology -- Monoclonal antibodies ; Biological sciences -- Biochemistry -- Metabolism -- Monoclonal antibodies
    ISSN: 00221899
    Source: Archival Journals (JSTOR)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 19
    Language: English
    In: The Journal of Infectious Diseases, 1 June 1992, Vol.165, pp.S195-S196
    Keywords: Health sciences -- Medical sciences -- Immunology -- Epitopes ; Biological sciences -- Biology -- Genetics -- Monoclonal antibodies ; Health sciences -- Medical conditions -- Infections -- Monoclonal antibodies ; Health sciences -- Health and wellness -- Public health -- Monoclonal antibodies ; Biological sciences -- Biology -- Genetics -- Monoclonal antibodies ; Physical sciences -- Chemistry -- Chemical compounds -- Monoclonal antibodies ; Biological sciences -- Biology -- Microbiology -- Monoclonal antibodies ; Physical sciences -- Chemistry -- Chemical compounds -- Monoclonal antibodies ; Health sciences -- Medical sciences -- Immunology -- Monoclonal antibodies ; Biological sciences -- Biochemistry -- Metabolism -- Monoclonal antibodies
    ISSN: 00221899
    Source: Archival Journals (JSTOR)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 20
    Language: English
    In: The Journal of Infectious Diseases, 1 March 2000, Vol.181(3), pp.1049-1054
    Description: Haemophilus ducreyi expresses a conserved hemoglobin-binding outer-membrane protein (HgbA). To test the role of HgbA in pathogenesis, we infected 9 adults with isolate 35000 and its isogenic hgbA-inactivated mutant (FX504) on their upper arms in a double-blinded, escalating dose-response study. Papules developed at similar rates at sites inoculated with the mutant or parent. The pustule-formation rate was 55% (95% confidence interval [CI], 30.8%-78.5%) at parent sites and 0 (95% CI, 0-10.5%) at mutant sites (P 〈 .0001). The recovery rate of H. ducreyi from surface cultures was 16% (n = 142) from parent sites and 0 (n = 213) from mutant sites (P 〈 .0001). H. ducreyi was recovered at biopsy from 6 of 7 parent sites and from 0 of 3 mutant sites. The results indicate that hemoglobin may be a critical source of heme or iron for the establishment of H. ducreyi infection in humans.
    Keywords: Physical sciences -- Chemistry -- Chemical compounds -- Haemophilus ducreyi ; Biological sciences -- Biology -- Microbiology -- Haemophilus ducreyi ; Biological sciences -- Biology -- Microbiology -- Haemophilus ducreyi ; Health sciences -- Medical conditions -- Infections -- Haemophilus ducreyi ; Physical sciences -- Chemistry -- Chemical compounds -- Haemophilus ducreyi ; Health sciences -- Medical diagnosis -- Diagnostic methods -- Haemophilus ducreyi ; Health sciences -- Medical sciences -- Pharmacology -- Haemophilus ducreyi ; Health sciences -- Medical sciences -- Immunology -- Haemophilus ducreyi ; Health sciences -- Medical conditions -- Physical trauma -- Haemophilus ducreyi ; Health sciences -- Health and wellness -- Public health -- Haemophilus ducreyi
    ISSN: 00221899
    E-ISSN: 15376613
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages