Kooperativer Bibliotheksverbund

Berlin Brandenburg

and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Type of Medium
Language
Year
  • 11
    Language: English
    In: Procedia in Vaccinology, 2010, Vol.2(1), pp.101-105
    Description: With respect to nosocomial influenza infections, the welfare of patients is best served by high rates of staff immunity against influenza. However, data from the Centers of Disease Control (CDC) in the USA and the Robert Koch-Institute (RKI) in Germany indicate that most of health care workers (HCWs) choose not to be vaccinated. Under voluntary influenza immunization standards, institutional influenza outbreaks occur every flu season. The question about the legality of implementation mandatory flu vaccination for HCWs is an ongoing debate, which covers several different positions. To characterize the attitudes of German HCWs toward mandatory influenza immunization, an anonymous questionnaire was offered to HCWs of the University Hospital in Frankfurt/Main / Germany. Our study showed that almost 70% of the respondents would accept mandatory influenza vaccination. In our opinion an annual influenza vaccination should be required for HCWs who care for immunocompromised patients and residents in long-term care if there will be a failure of voluntary vaccination programs. An informed declination should be obtained from employees who decline vaccination and these HCWs ought to work in uncritical areas of patient care.
    Keywords: Healthcare Worker ; Influenza ; Mandatory Vaccinations ; Vaccine Uptake Rate ; Biology ; Pharmacy, Therapeutics, & Pharmacology ; Public Health
    ISSN: 1877-282X
    E-ISSN: 1877-282X
    Source: ScienceDirect Journals (Elsevier)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 12
    Language: English
    In: Vaccine, 2010, Vol.28(29), pp.4548-4549
    Description: Despite official recommendations - e.g. from the Centers for Disease Control and Prevention (CDC) in the U.S.A. and the Robert Koch Institute (RKI) in Germany - and the availability of an effective vaccine, low influenza vaccine acceptance among HCWs is a problem detailed in many studies from all over...
    Keywords: Health Care Workers ; Influenza Vaccination ; Nurses ; Medicine ; Biology ; Veterinary Medicine ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 0264-410X
    E-ISSN: 1873-2518
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 13
    Language: English
    In: BMC Infectious Diseases, June 23, 2010, Vol.10, p.185
    Description: Background Vaccinia virus strain Lister Elstree (VACV) is a test virus in the DVV/RKI guidelines as representative of the stable enveloped viruses. Since the potential risk of laboratory-acquired infections with VACV persists and since the adverse effects of vaccination with VACV are described, the replacement of VACV by the modified vaccinia Ankara strain (MVA) was studied by testing the activity of different chemical biocides in three German laboratories. Methods The inactivating properties of different chemical biocides (peracetic acid, aldehydes and alcohols) were tested in a quantitative suspension test according to the DVV/RKI guideline. All tests were performed with a protein load of 10% fetal calf serum with both viruses in parallel using different concentrations and contact times. Residual virus was determined by endpoint dilution method. Results The chemical biocides exhibited similar virucidal activity against VACV and MVA. In three cases intra-laboratory differences were determined between VACV and MVA - 40% (v/v) ethanol and 30% (v/v) isopropanol are more active against MVA, whereas MVA seems more stable than VACV when testing with 0.05% glutardialdehyde. Test accuracy across the three participating laboratories was high. Remarkably inter-laboratory differences in the reduction factor were only observed in two cases. Conclusions Our data provide valuable information for the replacement of VACV by MVA for testing chemical biocides and disinfectants. Because MVA does not replicate in humans this would eliminate the potential risk of inadvertent inoculation with vaccinia virus and disease in non-vaccinated laboratory workers.
    Keywords: Vaccinia -- Health Aspects ; Vaccinia -- Prevention ; Vaccinia -- Risk Factors ; Disinfectants -- Chemical Properties ; Disinfectants -- Testing ; Disinfectants -- Health Aspects ; Immune Response -- Research ; Immune Response -- Physiological Aspects
    ISSN: 1471-2334
    Source: Cengage Learning, Inc.
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 14
    Language: English
    In: BMC Infectious Diseases, June 23, 2010, Vol.10, p.185
    Description: Background Vaccinia virus strain Lister Elstree (VACV) is a test virus in the DVV/RKI guidelines as representative of the stable enveloped viruses. Since the potential risk of laboratory-acquired infections with VACV persists and since the adverse effects of vaccination with VACV are described, the replacement of VACV by the modified vaccinia Ankara strain (MVA) was studied by testing the activity of different chemical biocides in three German laboratories. Methods The inactivating properties of different chemical biocides (peracetic acid, aldehydes and alcohols) were tested in a quantitative suspension test according to the DVV/RKI guideline. All tests were performed with a protein load of 10% fetal calf serum with both viruses in parallel using different concentrations and contact times. Residual virus was determined by endpoint dilution method. Results The chemical biocides exhibited similar virucidal activity against VACV and MVA. In three cases intra-laboratory differences were determined between VACV and MVA - 40% (v/v) ethanol and 30% (v/v) isopropanol are more active against MVA, whereas MVA seems more stable than VACV when testing with 0.05% glutardialdehyde. Test accuracy across the three participating laboratories was high. Remarkably inter-laboratory differences in the reduction factor were only observed in two cases. Conclusions Our data provide valuable information for the replacement of VACV by MVA for testing chemical biocides and disinfectants. Because MVA does not replicate in humans this would eliminate the potential risk of inadvertent inoculation with vaccinia virus and disease in non-vaccinated laboratory workers.
    Keywords: Vaccinia -- Health Aspects ; Vaccinia -- Prevention ; Vaccinia -- Risk Factors ; Disinfectants -- Chemical Properties ; Disinfectants -- Testing ; Disinfectants -- Health Aspects ; Immune Response -- Research ; Immune Response -- Physiological Aspects
    ISSN: 1471-2334
    Source: Cengage Learning, Inc.
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 15
    Language: English
    In: Medical Microbiology and Immunology, 2010, Vol.199(1), pp.45-51
    Description: Coxsackie A16 (CA16) and Enterovirus 71 (EV71) are members of the picornaviridae family and are associated with hand, foot and mouth disease (HFMD), in rare cases also to acute neurological diseases. HFMD outbreaks have been reported from many parts of the world, especially Southeast Asia. The objective of the study was to analyze CA16 and EV71 seroepidemiologically in the population of Frankfurt/M., Germany. A total of 696 individuals (349 males and 347 females, divided into seven different age groups, 1–4, 5–9, 10–14, 15–19, 20–39, 40–59 and 〉60 years) were tested for serum antibodies against CA16 and EV71 by the use of a microneutralization test. Sera were collected at the Frankfurt university hospital from patients suffering from other diseases between March and September 2006. CA16 and EV71 infections were observed to be widely present in the population. The age-adjusted seroprevalence for individuals ≥1 year was found to be 62.9% for CA16 and 42.8% for EV71 without a gender-specific significant difference. Only 12.0 and 27.0% of the children aged 1–4 had antibodies to EV71 and CA16, respectively – indicating that 88 and 73% of the children in this age group were susceptible to the infection. A total of 213 individuals (30.6%) was seropositive for both viruses, 303 (43.5%) showed neutralizing antibodies (NtAb) to at least one of the two viruses. A total of 180 individuals (25.9%) revealed no antibodies. High CA16 and EV71 antibody titers were found especially in the age group of the 10- to 14-year-olds, without gender-specific difference. The seroprevalence study demonstrates a common spread of CA16 and EV71 in Germany, but a relatively high susceptibility of the younger population to CA16 and EV71. Obviously, the manifestation rate, i.e., distinct disease of these infections is low.
    Keywords: Hand, foot and mouth disease ; Seroprevalence ; Coxsackie A16 ; Enterovirus 71 ; Neutralization assay
    ISSN: 0300-8584
    E-ISSN: 1432-1831
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 16
    Language: English
    In: BMC Infectious Diseases, 01 June 2010, Vol.10(1), p.185
    Description: Abstract Background Vaccinia virus strain Lister Elstree (VACV) is a test virus in the DVV/RKI guidelines as representative of the stable enveloped viruses. Since the potential risk of laboratory-acquired infections with VACV persists and since the adverse effects of vaccination with VACV are described, the replacement of VACV by the modified vaccinia Ankara strain (MVA) was studied by testing the activity of different chemical biocides in three German laboratories. Methods The inactivating properties of different chemical biocides (peracetic acid, aldehydes and alcohols) were tested in a quantitative suspension test according to the DVV/RKI guideline. All tests were performed with a protein load of 10% fetal calf serum with both viruses in parallel using different concentrations and contact times. Residual virus was determined by endpoint dilution method. Results The chemical biocides exhibited similar virucidal activity against VACV and MVA. In three cases intra-laboratory differences were determined between VACV and MVA - 40% (v/v) ethanol and 30% (v/v) isopropanol are more active against MVA, whereas MVA seems more stable than VACV when testing with 0.05% glutardialdehyde. Test accuracy across the three participating laboratories was high. Remarkably inter-laboratory differences in the reduction factor were only observed in two cases. Conclusions Our data provide valuable information for the replacement of VACV by MVA for testing chemical biocides and disinfectants. Because MVA does not replicate in humans this would eliminate the potential risk of inadvertent inoculation with vaccinia virus and disease in non-vaccinated laboratory workers.
    Keywords: Medicine
    ISSN: 1471-2334
    E-ISSN: 1471-2334
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 17
    Language: English
    In: Influenza and other respiratory viruses, January 2011, Vol.5(1), pp.61-6
    Description: Influenza viruses are highly contagious. Health care workers (HCWs) are at risk of occupational exposure to influenza and may transmit the infection to their patients and coworkers. The aim of the study was to characterize the attitudes of HCWs regarding the use of surgical masks to prevent nosocomial influenza transmission. Furthermore, we assessed the informational needs of HCWs with regard to infection control measures. A survey was conducted among HCWs, using an anonymous questionnaire, at a German University Hospital during an influenza vaccination campaign. Overall, 40·5% of the HCWs were vaccinated against seasonal influenza, and 35·2% were vaccinated against Influenza A/H1N1 ("swine flu"). In total, 1445 vaccinees completed the anonymous questionnaire. Of all respondents, 70·5% stated that the infection control recommendation "wearing a surgical" mask was appropriate to avoid influenza transmission. The percentage of HCWs who would like to have had more information about the infection control measures was 67·5%. Appropriate interventions ought to be taken to reduce the risk of exposure to influenza viruses among HCWs. Adherence to recommendations for the use of masks among HCWs needs to be evaluated. Further work is required to highlight the informational needs of HCWs to gain an appreciation of infection control measures.
    Keywords: Attitude of Health Personnel ; Cross Infection -- Prevention & Control ; Health Personnel -- Psychology ; Infection Control -- Instrumentation ; Influenza Vaccines -- Administration & Dosage ; Influenza, Human -- Prevention & Control ; Masks -- Statistics & Numerical Data
    E-ISSN: 1750-2659
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 18
    Language: English
    In: BMC Infectious Diseases, Jan 26, 2012, Vol.12, p.24
    Description: Background Europe was certified to be polio-free in 2002 by the WHO. However, wild polioviruses remain endemic in India, Pakistan, Afghanistan, and Nigeria, occasionally causing polio outbreaks, as in Tajikistan in 2010. Therefore, effective surveillance measures and vaccination campaigns remain important. To determine the poliovirus immune status of a German study population, we retrospectively evaluated the seroprevalence of neutralizing antibodies (NA) to the poliovirus types 1, 2 and 3 (PV1, 2, 3) in serum samples collected from 1,632 patients admitted the University Hospital of Frankfurt am Main, Germany, in 2001, 2005 and 2010. Methods Testing was done by using a standardized microneutralization assay. Results Level of immunity to PV1 ranged between 84.2% (95%CI: 80.3-87.5), 90.4% (88.3-92.3) and 87.5% (85.4-88.8) in 2001, 2005 and 2010. For PV2, we found 90.8% (87.5-90.6), 91.3% (89.3-93.1) and 89.8% (88.7-90.9), in the same period. Seroprevalence to PV3 was 76.6% (72.2-80.6), 69.8% (66.6-72.8) and 72.9% (67.8-77.5) in 2001 and 2005 and 2010, respectively. In 2005 and 2010 significant lower levels of immunity to PV3 in comparison to PV1 and 2 were observed. Since 2001, immunity to PV3 is gradually, but not significantly decreasing. Conclusion Immunity to PV3 is insufficient in our cohort. Due to increasing globalization and worldwide tourism, the danger of polio-outbreaks is not averted - even not in developed countries, such as Germany. Therefore, vaccination remains necessary.
    Keywords: Vaccination -- Analysis
    ISSN: 1471-2334
    Source: Cengage Learning, Inc.
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 19
    Language: English
    In: BMC Infectious Diseases, Jan 26, 2012, Vol.12, p.24
    Description: Background Europe was certified to be polio-free in 2002 by the WHO. However, wild polioviruses remain endemic in India, Pakistan, Afghanistan, and Nigeria, occasionally causing polio outbreaks, as in Tajikistan in 2010. Therefore, effective surveillance measures and vaccination campaigns remain important. To determine the poliovirus immune status of a German study population, we retrospectively evaluated the seroprevalence of neutralizing antibodies (NA) to the poliovirus types 1, 2 and 3 (PV1, 2, 3) in serum samples collected from 1,632 patients admitted the University Hospital of Frankfurt am Main, Germany, in 2001, 2005 and 2010. Methods Testing was done by using a standardized microneutralization assay. Results Level of immunity to PV1 ranged between 84.2% (95%CI: 80.3-87.5), 90.4% (88.3-92.3) and 87.5% (85.4-88.8) in 2001, 2005 and 2010. For PV2, we found 90.8% (87.5-90.6), 91.3% (89.3-93.1) and 89.8% (88.7-90.9), in the same period. Seroprevalence to PV3 was 76.6% (72.2-80.6), 69.8% (66.6-72.8) and 72.9% (67.8-77.5) in 2001 and 2005 and 2010, respectively. In 2005 and 2010 significant lower levels of immunity to PV3 in comparison to PV1 and 2 were observed. Since 2001, immunity to PV3 is gradually, but not significantly decreasing. Conclusion Immunity to PV3 is insufficient in our cohort. Due to increasing globalization and worldwide tourism, the danger of polio-outbreaks is not averted - even not in developed countries, such as Germany. Therefore, vaccination remains necessary.
    Keywords: Vaccination -- Analysis
    ISSN: 1471-2334
    Source: Cengage Learning, Inc.
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 20
    Language: English
    In: Reviews in Infection, July, 2010, Vol.1(3), p.166(6)
    Description: Background: Human cytomegalovirus (HCMV) is the most frequent viral pathogen in bone marrow transplant (BMT) patients, where it causes significant morbidity and mortality. The results of the two most frequently used laboratory assays for the detection of active HCMV infection, the pp65-antigenemia assay and the polymerase chain reaction (PCR), often differ in BMT patients. Within the context of limited financial resources it is necessary to economize routine laboratory diagnostic procedures. To evaluate if the pp65-antigenemia assay can be replaced by HCMV-PCR we retrospectively assessed 988 samples from 253 BMT patients without additional information on the patient's clinical presentation or therapy. Material and Methods: The results of both assay (a commercially available pp65-antigen assay and an in-house quantitative real time HCMV-PCR) were classified into four different quantitative groups: PCR group (PCR-g) 0 = PCR neg. (〈200 copies/ml); PCR-g 1 = 200-999 copies/ml; PCR-g 2 = 1,000- 9,999 copies/ml; PCR-g 3 = 〉9,999 copies/ml; pp65-antigen group (pp65-g) 0 = 0 positive cells/400,000 leucocytes; pp65-g 1 = 1-3 pos. cells; pp65-g 2 = 4-99 pos. cells and pp65-g 3 = 〉99 pos. cells. Results: The mean value of PCR copies rises with the number of pp65-antigen (pp65-Ag) positive cells in the antigenemia assay. However, in the pp65-g 0 the mean value and the range of the PCR copies are higher than in the pp65-g 1 (pp65-g 0: 1,188 copies, range: 0-200,000 copies; pp65-g 1: 554 copies range: 0-12,900). There is a statistically significant correlation between the results of the pp65-Ag-assay and quantitative PCR (spearman-correlation: cumulative: 0.49, p = 0.01; pp65-g 2: 0.38, p= 0.01; pp65-g 3: 0.44, p = 0.01). Regarding PCR groups, there is no correlation with the results of the quantitative antigenemia assay. Using any positive PCR result as the reference, the pp65-Ag-assay showed 59% / 77% / 60% / 76% for sensitivity / specificity/ positive predictive value / negative predictive value, respectively and a positive likelihood ratio of 2.6. These values rose with the number of PCR copies and pp65-positive cells. A highly positive result (pp65-g 3 (〉99 cells) or PCR-g 3 (〉 9,999 copies/ml)) of either test almost certainly excludes the possibility of a negative result of the other test. Conclusion: When the pp65-Ag result is greater than 3 positive cells per 400,000 leucocytes, the pp65-Ag-assay and the plasma PCR parallel each other. However, highly positive PCR results can be obtained in pp65-Ag-assay negative samples. Our results suggest that both assays complement each other and should be used concomitant. Keywords: Cytomegalovirus, HCMV, pp65, antigenemia, PCR
    Keywords: Physiologic Monitoring -- Methods ; Medical Tests -- Research ; Bone Marrow Transplantation -- Patient Outcomes
    ISSN: 1837-6738
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages