Format:
Online-Ressource
ISSN:
1616-3028
Content:
Abstract: Endometriosis is a prevalent gynecological disorder characterized by the presence of endometrial‐like tissue outside the uterus, causing chronic pelvic pain, painful periods, and infertility. Despite the common use of hormone therapy and surgical lesion excision in its treatment, there remain significant postoperative risks and potential side effects, with a high recurrence rate. An efficient nonsurgical treatment for this condition is therefore urgently needed. In this study, an interventional hydrogel microsphere with near‐infrared (NIR)‐controlled curcumin release is developed for the non‐invasive thermal therapy of endometriosis. The hydrogel microspheres demonstrate good biocompatibility and photothermal activities, causing the death of endometrial stromal cells under NIR and controlled curcumin (Cur) release. When injected into endometriotic lesions and stimulated by NIR light, the interventional hydrogel microspheres (Cur‐FeHMPs) can raise the temperature of the endometriotic lesions to 43.65 °C, inducing endometriotic lesion elimination. Furthermore, the controlled curcumin release from the interventional hydrogel inhibits the proinflammatory environment in endometriosis. The Cur‐FeHMPs in combination with NIR present a novel strategy for endometriosis treatment.
In:
day:23
In:
month:02
In:
year:2024
In:
extent:12
In:
Advanced functional materials, Weinheim : Wiley-VCH, [2001]-, (23.02.2024) (gesamt 12), 1616-3028
Language:
English
DOI:
10.1002/adfm.202315907
URN:
urn:nbn:de:101:1-2024022414081540258023
URL:
https://doi.org/10.1002/adfm.202315907
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2024022414081540258023
URL:
https://d-nb.info/1321613318/34
URL:
https://doi.org/10.1002/adfm.202315907
Bookmarklink