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1

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Comparison of high-dose and low-dose corticosteroid therapy for refractory Mycoplasma pneumoniae pneumonia in children

Okumura, Toshihiko ; Kawada, Jun-ichi ; Tanaka, Masaharu ; [weitere]

Elsevier BV ; 2019

In: Journal of Infection and Chemotherapy Vol. 25, No. 5 ( 2019-05), p. 346-350

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In: Journal of Infection and Chemotherapy, Elsevier BV, Vol. 25, No. 5 ( 2019-05), p. 346-350

Materialart: Online-Ressource

ISSN: 1341-321X

URL: Article

DOI: 10.1016/j.jiac.2019.01.003

Sprache: Englisch

Verlag: Elsevier BV

Publikationsdatum: 2019

ZDB Id: 1481768-8

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dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project

Ogishima, Soichi ; Nagaie, Satoshi ; Mizuno, Satoshi ; [weitere]

Springer Science and Business Media LLC ; 2021

In: Human Genome Variation Vol. 8, No. 1 ( 2021-12-10)

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In: Human Genome Variation, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2021-12-10)

Kurzfassung: To reveal gene-environment interactions underlying common diseases and estimate the risk for common diseases, the Tohoku Medical Megabank (TMM) project has conducted prospective cohort studies and genomic and multiomics analyses. To establish an integrated biobank, we developed an integrated database called “dbTMM” that incorporates both the individual cohort/clinical data and the genome/multiomics data of 157,191 participants in the Tohoku Medical Megabank project. To our knowledge, dbTMM is the first database to store individual whole-genome data on a variant-by-variant basis as well as cohort/clinical data for over one hundred thousand participants in a prospective cohort study. dbTMM enables us to stratify our cohort by both genome-wide genetic factors and environmental factors, and it provides a research and development platform that enables prospective analysis of large-scale data from genome cohorts.

Materialart: Online-Ressource

ISSN: 2054-345X

URL: Article

DOI: 10.1038/s41439-021-00175-5

Sprache: Englisch

Verlag: Springer Science and Business Media LLC

Publikationsdatum: 2021

ZDB Id: 2863697-1

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3

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Influenza A(H1N1)pdm09 virus exhibiting reduced susceptibility to baloxavir due to a PA E23K substitution detected from a child without baloxavir treatment

Takashita, Emi ; Abe, Takashi ; Morita, Hiroko ; [weitere]

Elsevier BV ; 2020

In: Antiviral Research Vol. 180 ( 2020-08), p. 104828-

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In: Antiviral Research, Elsevier BV, Vol. 180 ( 2020-08), p. 104828-

Materialart: Online-Ressource

ISSN: 0166-3542

URL: Article

DOI: 10.1016/j.antiviral.2020.104828

Sprache: Englisch

Verlag: Elsevier BV

Publikationsdatum: 2020

ZDB Id: 1495861-2

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4

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Effect of febuxostat on left ventricular diastolic function in patients with asymptomatic hyperuricemia: a sub analysis of the PRIZE Study

Kusunose, Kenya ; Yoshida, Hisako ; Tanaka, Atsushi ; [weitere]

Springer Science and Business Media LLC ; 2022

In: Hypertension Research Vol. 45, No. 1 ( 2022-01), p. 106-115

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In: Hypertension Research, Springer Science and Business Media LLC, Vol. 45, No. 1 ( 2022-01), p. 106-115

Kurzfassung: Hyperuricemia is related to an increased risk of cardiovascular events from a meta-analysis and antihyperuricemia agents may influence to cardiac function. We evaluated the effect of febuxostat on echocardiographic parameters of diastolic function in patients with asymptomatic hyperuricemia as a prespecified endpoint in the subanalysis of the PRIZE study. Patients in the PRIZE study were assigned randomly to either add-on febuxostat treatment group or control group with only appropriate lifestyle modification. Of the 514 patients in the overall study, 65 patients (31 in the febuxostat group and 34 in the control group) who had complete follow-up echocardiographic data of the ratio of peak early diastolic transmitral flow velocity (E) to peak early diastolic mitral annular velocity (e′) at baseline and after 12 and 24 months were included. The primary endpoint was a comparison of the changes in the E/e′ between the two groups from baseline to 24 months. Interestingly, e′ was slightly decreased in the control group compared with in the febuxostat group (treatment p = 0.068, time, p = 0.337, treatment × Time, p = 0.217). As a result, there were significant increases in E/e′ (treatment p = 0.045, time, p = 0.177, treatment × time, p = 0.137) after 24 months in the control group compared with the febuxostat group. There was no significant difference in the serum levels of N-terminal-pro brain natriuretic peptide and high-sensitive troponin I between the two groups during the study period. In conclusions, additional febuxostat treatment in patients with asymptomatic hyperuricemia for 24 months might have a potential of preventable effects on the impaired diastolic dysfunction.

Materialart: Online-Ressource

ISSN: 0916-9636 , 1348-4214

URL: Article

DOI: 10.1038/s41440-021-00752-9

Sprache: Englisch

Verlag: Springer Science and Business Media LLC

Publikationsdatum: 2022

ZDB Id: 2110941-2

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Factors associated with carotid intima-media thickness progression in patients with asymptomatic hyperuricemia: insights from the PRIZE study

Saito, Yuichi ; Tanaka, Atsushi ; Ishizu, Tomoko ; [weitere]

Springer Science and Business Media LLC ; 2023

In: Scientific Reports Vol. 13, No. 1 ( 2023-07-05)

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In: Scientific Reports, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2023-07-05)

Kurzfassung: Hyperuricemia is reportedly associated with the progression of carotid intima-media thickness (IMT), a surrogate of cardiovascular risks and events. However, factors associated with carotid IMT progression in patients with asymptomatic hyperuricemia are largely unknown. In this post-hoc analysis of the multicenter, randomized PRIZE study, we analyzed data from a total of 326 patients who underwent carotid ultrasonography in a blind manner at baseline and 24 months to evaluate carotid IMT. Mean and maximum IMT at the common carotid artery (CCA) were measured at a central core laboratory. Factors related to the absolute change in mean and maximum IMT from baseline to 24 months were explored. Overall, the adjusted mean [0.0032 (− 0.0214 to 0.0278) mm] and maximum [0.0011 (− 0.0327 to 0.0351) mm] CCA-IMT increased numerically from baseline to 24 months. Multivariable analysis identified higher body mass index, history of atherosclerotic cardiovascular disease (ASCVD), and lower mean CCA-IMT at baseline as significant factors associated with the increase in mean CCA-IMT. In addition, older age and lower mean CCA-IMT at baseline were significant factors for an increased absolute change in the maximum CCA-IMT at 24 months. The present sub-analysis of the PRIZE study showed higher body mass index, history of ASCVD, and older age as significant factors associated with CCA-IMT progression in patients with asymptomatic hyperuricemia. These factors may be considered when identifying the possible risk of atherosclerotic progression in this specific patient population of hyperuricemia. Trial registration: UMIN000012911 and UMIN000041322.

Materialart: Online-Ressource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/s41598-023-37183-0

Sprache: Englisch

Verlag: Springer Science and Business Media LLC

Publikationsdatum: 2023

ZDB Id: 2615211-3

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6

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Predictive Value of the Cardio‐Ankle Vascular Index for Cardiovascular Events in Patients at Cardiovascular Risk

Miyoshi, Toru ; Ito, Hiroshi ; Shirai, Kohji ; [weitere]

Ovid Technologies (Wolters Kluwer Health) ; 2021

In: Journal of the American Heart Association Vol. 10, No. 16 ( 2021-08-17)

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In: Journal of the American Heart Association, Ovid Technologies (Wolters Kluwer Health), Vol. 10, No. 16 ( 2021-08-17)

Kurzfassung: Arterial stiffness is an important predictor of cardiovascular events; however, indexes for measuring arterial stiffness have not been widely incorporated into routine clinical practice. This study aimed to determine whether the cardio‐ankle vascular index (CAVI), based on the blood pressure–independent stiffness parameter β and reflecting arterial stiffness from the origin of the ascending aorta, is a good predictor of cardiovascular events in patients with cardiovascular disease risk factors in a large prospective cohort. Methods and Results This multicenter prospective cohort study, commencing in May 2013, with a 5‐year follow‐up period, included patients (aged 40‒74 years) with cardiovascular disease risks. The primary outcome was the composite of cardiovascular death, nonfatal stroke, or nonfatal myocardial infarction. Among 2932 included patients, 2001 (68.3%) were men; the mean (SD) age at diagnosis was 63 (8) years. During the median follow‐up of 4.9 years, 82 participants experienced primary outcomes. The CAVI predicted the primary outcome (hazard ratio, 1.38; 95% CI, 1.16‒1.65; P 〈 0.001). In terms of event subtypes, the CAVI was associated with cardiovascular death and stroke but not with myocardial infarction. When the CAVI was incorporated into a model with known cardiovascular disease risks for predicting cardiovascular events, the global χ 2 value increased from 33.8 to 45.2 ( P 〈 0.001), and the net reclassification index was 0.254 ( P =0.024). Conclusions This large cohort study demonstrated that the CAVI predicted cardiovascular events. Registration URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01859897.

Materialart: Online-Ressource

ISSN: 2047-9980

URL: Article

DOI: 10.1161/JAHA.120.020103

Sprache: Englisch

Verlag: Ovid Technologies (Wolters Kluwer Health)

Publikationsdatum: 2021

ZDB Id: 2653953-6

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7

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Syncopal‐type reactions tend to be delayed and result in falls among elderly blood donors

Namba, Noriko ; Ishimaru, Fumihiko ; Kondo, Gaku ; [weitere]

Wiley ; 2021

In: Vox Sanguinis Vol. 116, No. 1 ( 2021-01), p. 36-41

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In: Vox Sanguinis, Wiley, Vol. 116, No. 1 ( 2021-01), p. 36-41

Kurzfassung: Delayed syncopal‐type complications are infrequent among blood donors, but sometimes have critical consequences, such as severe injury. We retrospectively investigated the characteristics of donors with delayed syncopal‐type complications or falls. Study design and methods We defined a delayed reaction (DR) as syncopal‐type complications occurring 〉 20 min after needle removal. Subjects were stratified by sex, age, estimated blood volume (EBV), body mass index (BMI) and frequency of donation. Multiple logistic regression analysis and propensity score weighted M estimation were performed to evaluate the covariate‐adjusted risk of syncopal DRs among donors giving 400 ml of whole blood (WB). The DR rate was calculated as the number of DRs divided by the number of all syncopal‐type reactions after needle removal. The risk of falls was assessed similarly. Donors who discontinued before completing phlebotomy (donation of 400 ml) were excluded. Results Among 3818 syncopal‐type reactions after needle removal, there were 359 DRs and 93 falls. Elderly donors and female donors with syncopal‐type reactions had a significantly higher risk of DRs ( P for trend 〈 0·001). Elderly donors with syncopal‐type reactions also had a higher risk of falls ( P for trend 〈 0·001). Among all donors with syncopal‐type reactions, the risk of DRs or falls was not correlated with EBV, BMI or donation frequency. Conclusion In female donors and elderly donors (donating 400 ml of WB), syncopal‐type reactions tended to be delayed. Elderly donors with syncopal‐type reactions had a significantly higher risk of falls.

Materialart: Online-Ressource

ISSN: 0042-9007 , 1423-0410

URL: Issue

URL: Article

DOI: 10.1111/vox.v116.1

DOI: 10.1111/vox.12981

Sprache: Englisch

Verlag: Wiley

Publikationsdatum: 2021

ZDB Id: 1483587-3

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8

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Development of scale to measure nurses' difficulty with cancer care (NDCC)

Onodera, Mai ; Kumata, Makiko ; Ogiri, Noriko ; [weitere]

Japanese Society for Palliative Medicine ; 2013

In: Palliative Care Research Vol. 8, No. 2 ( 2013), p. 240-247

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In: Palliative Care Research, Japanese Society for Palliative Medicine, Vol. 8, No. 2 ( 2013), p. 240-247

Materialart: Online-Ressource

ISSN: 1880-5302

Originaltitel: 看護師のがん看護に関する困難感尺度の作成

URL: Article

DOI: 10.2512/jspm.8.240

Sprache: Englisch , Japanisch

Verlag: Japanese Society for Palliative Medicine

Publikationsdatum: 2013

ZDB Id: 2397005-4

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Difficulty with cancer care and related factors among nurses at Tohoku University Hospital

Miyashita, Mitsunori ; Onodera, Mai ; Kumata, Makiko ; [weitere]

Japanese Society for Palliative Medicine ; 2014

In: Palliative Care Research Vol. 9, No. 3 ( 2014), p. 158-166

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In: Palliative Care Research, Japanese Society for Palliative Medicine, Vol. 9, No. 3 ( 2014), p. 158-166

Materialart: Online-Ressource

ISSN: 1880-5302

Originaltitel: 東北大学病院の看護師のがん看護に関する困難感とその関連要因

URL: Article

DOI: 10.2512/jspm.9.158

Sprache: Englisch , Japanisch

Verlag: Japanese Society for Palliative Medicine

Publikationsdatum: 2014

ZDB Id: 2397005-4

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末梢血幹細胞採取にアフェレーシスナースが果たしている役割と人的支援のニーズに関するアンケート調査

Namba, Noriko ; Shibata, Reiko ; Yoshida, Kotoe ; [weitere]

Japan Society of Transfusion Medicine and Cell Therapy ; 2023

In: Japanese Journal of Transfusion and Cell Therapy Vol. 69, No. 3 ( 2023-6-26), p. 464-469

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In: Japanese Journal of Transfusion and Cell Therapy, Japan Society of Transfusion Medicine and Cell Therapy, Vol. 69, No. 3 ( 2023-6-26), p. 464-469

Materialart: Online-Ressource

ISSN: 1881-3011 , 1883-0625

URL: Article

DOI: 10.3925/jjtc.69.464

Sprache: Englisch

Verlag: Japan Society of Transfusion Medicine and Cell Therapy

Publikationsdatum: 2023

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Berlin Brandenburg