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1

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Expression Level of Neural Cell Adhesion Molecule (NCAM) Inversely Correlates with the Ability of Neuroblastoma Cells to Adhere to Endothelium In Vitro

Blaheta, Roman A. ; Hundemer, Michael ; Mayer, Gottfried ; [et al.]

Informa UK Limited ; 2002

In: Cell Communication & Adhesion Vol. 9, No. 3 ( 2002-01), p. 131-147

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In: Cell Communication & Adhesion, Informa UK Limited, Vol. 9, No. 3 ( 2002-01), p. 131-147

Type of Medium: Online Resource

ISSN: 1541-9061 , 1543-5180

URL: Article

DOI: 10.1080/15419060214520

Language: English

Publisher: Informa UK Limited

Publication Date: 2002

detail.hit.zdb_id: 2030743-3

SSG: 12

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2

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Failure of Antiretroviral Therapy: Role of Viral and Cellular Factors

Cinatl, Jr., Jindrich ; Cinatl, Jaroslav ; Rabenau, Holger ; [et al.]

S. Karger AG ; 1994

In: Intervirology Vol. 37, No. 6 ( 1994), p. 307-314

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In: Intervirology, S. Karger AG, Vol. 37, No. 6 ( 1994), p. 307-314

Type of Medium: Online Resource

ISSN: 0300-5526 , 1423-0100

URL: Article

DOI: 10.1159/000150394

RVK:

XA 10000

Language: English

Publisher: S. Karger AG

Publication Date: 1994

detail.hit.zdb_id: 1482863-7

SSG: 12

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3

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Kultivierung von Iriszellen in vitro12

Weimer, Eveline G. ; Cínatl Jr, Jindrich ; Cínatl, Jaroslaw ; [et al.]

Georg Thieme Verlag KG ; 2000

In: Klinische Monatsblätter für Augenheilkunde Vol. 217, No. 6 ( 2000-12), p. 356-362

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In: Klinische Monatsblätter für Augenheilkunde, Georg Thieme Verlag KG, Vol. 217, No. 6 ( 2000-12), p. 356-362

Type of Medium: Online Resource

ISSN: 0023-2165 , 1439-3999

URL: Article

DOI: 10.1055/s-2000-9575

RVK:

XA 10000

Language: Unknown

Publisher: Georg Thieme Verlag KG

Publication Date: 2000

detail.hit.zdb_id: 2039754-9

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4

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Cytomegalovirus Infection Decreases Expression of Thrombospondin‐1 and ‐2 in Cultured Human Retinal Glial Cells: Effects of Antiviral Agents

Cinatl, Jr., Jindrich ; Bittoova, Martina ; Margraf, Stefan ; [et al.]

Oxford University Press (OUP) ; 2000

In: The Journal of Infectious Diseases Vol. 182, No. 3 ( 2000-09), p. 643-651

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In: The Journal of Infectious Diseases, Oxford University Press (OUP), Vol. 182, No. 3 ( 2000-09), p. 643-651

Type of Medium: Online Resource

ISSN: 0022-1899 , 1537-6613

URL: Issue

URL: Article

DOI: 10.1086/jid.2000.182.issue-3

DOI: 10.1086/315779

RVK:

XA 10000

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2000

detail.hit.zdb_id: 1473843-0

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5

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Human Cytomegalovirus Infection Decreases Expression of Thrombospondin-1 Independent of the Tumor Suppressor Protein p53

Cinatl Jr., Jindrich ; Kotchetkov, Ruslan ; Scholz, Martin ; [et al.]

Elsevier BV ; 1999

In: The American Journal of Pathology Vol. 155, No. 1 ( 1999-07), p. 285-292

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In: The American Journal of Pathology, Elsevier BV, Vol. 155, No. 1 ( 1999-07), p. 285-292

Type of Medium: Online Resource

ISSN: 0002-9440

URL: Article

DOI: 10.1016/S0002-9440(10)65122-X

RVK:

XA 10000

RVK:

XA 19800

Language: English

Publisher: Elsevier BV

Publication Date: 1999

detail.hit.zdb_id: 1480207-7

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6

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Modulatory Effects of Human Cytomegalovirus Infection on Malignant Properties of Cancer Cells

Cinatl Jr, Jindrich ; Cinatl, Jaroslav ; Vogel, Jens-U. ; [et al.]

S. Karger AG ; 1996

In: Intervirology Vol. 39, No. 4 ( 1996), p. 259-269

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In: Intervirology, S. Karger AG, Vol. 39, No. 4 ( 1996), p. 259-269

Type of Medium: Online Resource

ISSN: 0300-5526 , 1423-0100

URL: Article

DOI: 10.1159/000150527

RVK:

XA 10000

Language: English

Publisher: S. Karger AG

Publication Date: 1996

detail.hit.zdb_id: 1482863-7

SSG: 12

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7

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Non-Phosphorylatable PEA-15 Sensitises SKOV-3 Ovarian Cancer Cells to Cisplatin

Dilruba, Shahana ; Grondana, Alessia ; Schiedel, Anke C. ; [et al.]

MDPI AG ; 2020

In: Cells Vol. 9, No. 2 ( 2020-02-24), p. 515-

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In: Cells, MDPI AG, Vol. 9, No. 2 ( 2020-02-24), p. 515-

Abstract: The efficacy of cisplatin-based chemotherapy in ovarian cancer is often limited by the development of drug resistance. In most ovarian cancer cells, cisplatin activates extracellular signal-regulated kinase1/2 (ERK1/2) signalling. Phosphoprotein enriched in astrocytes (PEA-15) is a ubiquitously expressed protein, capable of sequestering ERK1/2 in the cytoplasm and inhibiting cell proliferation. This and other functions of PEA-15 are regulated by its phosphorylation status. In this study, the relevance of PEA-15 phosphorylation state for cisplatin sensitivity of ovarian carcinoma cells was examined. The results of MTT-assays indicated that overexpression of PEA-15AA (a non-phosphorylatable variant) sensitised SKOV-3 cells to cisplatin. Phosphomimetic PEA-15DD did not affect cell sensitivity to the drug. While PEA-15DD facilitates nuclear translocation of activated ERK1/2, PEA-15AA acts to sequester the kinase in the cytoplasm as shown by Western blot. Microarray data indicated deregulation of thirteen genes in PEA-15AA-transfected cells compared to non-transfected or PEA-15DD-transfected variants. Data derived from The Cancer Genome Atlas (TCGA) showed that the expression of seven of these genes including EGR1 (early growth response protein 1) and FLNA (filamin A) significantly correlated with the therapy outcome in cisplatin-treated cancer patients. Further analysis indicated the relevance of nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) signalling for the favourable effect of PEA-15AA on cisplatin sensitivity. The results warrant further evaluation of the PEA-15 phosphorylation status as a potential candidate biomarker of response to cisplatin-based chemotherapy.

Type of Medium: Online Resource

ISSN: 2073-4409

URL: Article

DOI: 10.3390/cells9020515

Language: English

Publisher: MDPI AG

Publication Date: 2020

detail.hit.zdb_id: 2661518-6

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8

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A systems pharmacology approach to improve drug therapy in NSCLC: Establishing a CESAR network

Kalayda, Ganna V. ; Michaelis, Martin ; jr., Jindrich Cinatl ; [et al.]

Dustri-Verlgag Dr. Karl Feistle ; 2014

In: Int. Journal of Clinical Pharmacology and Therapeutics Vol. 52, No. 01 ( 2014-01-01), p. 89-91

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In: Int. Journal of Clinical Pharmacology and Therapeutics, Dustri-Verlgag Dr. Karl Feistle, Vol. 52, No. 01 ( 2014-01-01), p. 89-91

Type of Medium: Online Resource

ISSN: 0946-1965

URL: Article

DOI: 10.5414/CPXCES13EA07

Language: English

Publisher: Dustri-Verlgag Dr. Karl Feistle

Publication Date: 2014

SSG: 12

SSG: 15,3

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9

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Knowledge-based approach to identify key determinants of cisplatin sensitivity 

Sarin, Navin ; Engel, Florian ; Kalayda, Ganna ; [et al.]

Dustri-Verlgag Dr. Karl Feistle ; 2017

In: Int. Journal of Clinical Pharmacology and Therapeutics Vol. 55, No. 08 ( 2017-08-01), p. 686-689

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In: Int. Journal of Clinical Pharmacology and Therapeutics, Dustri-Verlgag Dr. Karl Feistle, Vol. 55, No. 08 ( 2017-08-01), p. 686-689

Type of Medium: Online Resource

ISSN: 0946-1965

URL: Article

DOI: 10.5414/CPXCES15EA04

Language: English

Publisher: Dustri-Verlgag Dr. Karl Feistle

Publication Date: 2017

SSG: 12

SSG: 15,3

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10

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Cytomegalovirus and Cancer: A Long and Winding Road to Conclusive Evidence

Cinatl Jr, Jindrich

Sci Forschen, Inc. ; 2016

In: Journal of Emerging Diseases and Virology Vol. 1, No. 1 ( 2016)

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In: Journal of Emerging Diseases and Virology, Sci Forschen, Inc., Vol. 1, No. 1 ( 2016)

Type of Medium: Online Resource

ISSN: 2473-1846

URL: Journal

URL: Article

DOI: 10.16966/2473-1846

DOI: 10.16966/2473-1846.106

Language: Unknown

Publisher: Sci Forschen, Inc.

Publication Date: 2016

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Kooperativer Bibliotheksverbund

Berlin Brandenburg