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Betulinic acid: A natural product with anticancer activity (2008)

Fulda, Simone [Verfasser]

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UID:

(DE-101)1286484936

Umfang: Online-Ressource

ISSN: 1613-4133

Inhalt: Abstract: Betulinic acid (BA) is a naturally occurring pentacyclic triterpene that exhibits a variety of biological activities including potent antitumor properties. This anticancer activity has been linked to its ability to directly trigger mitochondrial membrane permeabilization, a central event in the apoptotic process that seals the cell's fate. In contrast to the potent cytotoxicity of BA against a variety of cancer types, nonmalignant cells and normal tissue remained relatively resistant to BA, indicating a therapeutic window. Since agents that exert a direct action on mitochondria may trigger cell death under circumstances in which standard chemotherapeutics fail, there is increasing interest to develop such compounds as experimental cancer therapeutics. Thus, mitochondrion‐targeted agents such as BA hold great promise as a novel approach to bypass certain forms of drug resistance in human cancers.

In: volume:53

In: number:1

In: year:2008

In: pages:140-146

In: extent:7

In: Molecular nutrition & food research, Weinheim : Wiley-VCH, [2004]-, 53, Heft 1 (2008), 140-146 (gesamt 7), 1613-4133

Sprache: Englisch

DOI: 10.1002/mnfr.200700491

URN: urn:nbn:de:101:1-2023041805022416809334

URL: https://doi.org/10.1002/mnfr.200700491

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2023041805022416809334

URL: https://d-nb.info/1286484936/34

URL: https://doi.org/10.1002/mnfr.200700491

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Molecular Targeted Therapies for Rhabdomyosarcoma: Focus on Hedgehog and Apoptosis Signaling (2013)

Fulda, Simone [Mitwirkender] 1968-

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UID:

(DE-101)1169704778

Umfang: Online-Ressource

ISSN: 1439-3824

In: volume:225

In: number:03

In: year:2013

In: pages:115-119

In: Klinische Pädiatrie, Stuttgart : Thieme, 1980-, 225, Heft 03 (2013), 115-119, 1439-3824

Sprache: Englisch

DOI: 10.1055/s-0032-1331762

URN: urn:nbn:de:101:1-2018102315295191125050

URL: https://doi.org/10.1055/s-0032-1331762

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2018102315295191125050

URL: https://d-nb.info/1169704778/34

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Regulation of cell death in cancer - possible implications for immunotherapy (2013)

Fulda, Simone [Verfasser] 1968-

Frankfurt am Main : Univ.-Bibliothek Frankfurt am Main

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UID:

(DE-101)1081034394

Umfang: Online-Ressource

In: In: Frontiers in oncology, 3.2013, article 29

Sprache: Englisch

URN: urn:nbn:de:hebis:30:3-274105

URL: https://nbn-resolving.org/urn:nbn:de:hebis:30:3-274105

URL: https://d-nb.info/1081034394/34

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Redox regulation of Smac mimetic-induced cell death (2015)

Fulda, Simone [Verfasser]

Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg

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UID:

(DE-603)452969212

ISSN: 2372-3556

Inhalt: Cell death and survival programs are controlled by the cellular redox state, which is typically dysregulated during oncogenesis. A recent study reports that the inhibition of antioxidant defenses resulting from glutathione depletion can prime acute lymphoblastic leukemia cells for death induced by Smac mimetics.

In: Molecular & cellular oncology, London : Taylor & Francis, 2014-, Band 2, Heft 4 (2015), Seite 1-2, Artikel-ID: e1000697, 2372-3556

In: volume:2

In: year:2015

In: number:4

In: pages:1-2

In: extent:3

In: elocationid:e1000697

Sprache: Englisch

DOI: 10.1080/23723556.2014.1000697

URN: urn:nbn:de:hebis:30:3-506739

URL: kostenfrei

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Targeting apoptosis signaling in pancreatic cancer (2011)

Fulda, Simone 1968-

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UID:

(DE-603)272541575

Umfang: Online-Ressource

ISSN: 2072-6694

Inhalt: The ability to escape apoptosis or programmed cell death is a hallmark of human cancers, for example pancreatic cancer. This can promote tumorigenesis, since too little cell death by apoptosis disturbs tissue homeostasis. Additionally, defective apoptosis signaling is the underlying cause of failure to respond to current treatment approaches, since therapy-mediated antitumor activity requires the intactness of apoptosis signaling pathways in cancer cells. Thus, the elucidation of defects in the regulation of apoptosis in pancreatic carcinoma can result in the identification of novel targets for therapeutic interference and for exploitation for cancer drug discovery.

In: Cancers, Basel : MDPI, 2009-, Band 3 (2011), Seite 241-251, 2072-6694

In: volume:3

In: year:2011

In: pages:241-251

Sprache: Englisch

DOI: 10.3390/cancers3010241

URN: urn:nbn:de:hebis:30-100343

URL: kostenfrei

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Shifting the balance of mitochondrial apoptosis: therapeutic perspectives (2013)

Fulda, Simone 1968-

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UID:

(DE-603)331433079

Umfang: Online-Ressource

ISSN: 2234-943X

Inhalt: Signaling via the intrinsic (mitochondrial) pathway of apoptosis represents one of the critical signal transduction cascades that control the regulation of cell death. This pathway is typically altered in human cancers, thereby providing a suitable target for therapeutic intervention. Members of the Bcl-2 family of proteins as well as cell survival signaling cascades such as the PI3K/Akt/mTOR pathway are involved in the regulation of mitochondria-mediated apoptosis. Therefore, further insights into the molecular mechanisms that form the basis for the control of mitochondria-mediated apoptosis will likely open new perspectives to bypass evasion of apoptosis and treatment resistance in human cancers.

In: Frontiers in oncology, Lausanne : Frontiers Media, 2011-, Band 2, Heft 121 (2012), 2234-943X

In: volume:2

In: year:2012

In: number:121

In: extent:4

Sprache: Englisch

DOI: 10.3389/fonc.2012.00121

URN: urn:nbn:de:hebis:30:3-286237

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Alternative cell death pathways and cell metabolism (2012)

Fulda, Simone 1968-

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UID:

(DE-603)332507106

Umfang: Online-Ressource

ISSN: 1687-8884

Inhalt: While necroptosis has for long been viewed as an accidental mode of cell death triggered by physical or chemical damage, it has become clear over the last years that necroptosis can also represent a programmed form of cell death in mammalian cells. Key discoveries in the field of cell death research, including the identification of critical components of the necroptotic machinery, led to a revised concept of cell death signaling programs. Several regulatory check and balances are in place in order to ensure that necroptosis is tightly controlled according to environmental cues and cellular needs. This network of regulatory mechanisms includes metabolic pathways, especially those linked to mitochondrial signaling events. A better understanding of these signal transduction mechanisms will likely contribute to open new avenues to exploit our knowledge on the regulation of necroptosis signaling for therapeutic application in the treatment of human diseases.

In: International journal of cell biology, New York, NY : Hindawi, 2009-, (2013), Artikel-ID: 463637, 1687-8884

In: year:2013

In: extent:4

In: elocationid:463637

Sprache: Englisch

DOI: 10.1155/2013/463637

URN: urn:nbn:de:hebis:30:3-289602

URL: kostenfrei

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Regulation of cell death in cancer - possible implications for immunotherapy (2013)

Fulda, Simone 1968-

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UID:

(DE-603)332979180

Umfang: Online-Ressource

ISSN: 2234-943X

Inhalt: Since most anticancer therapies including immunotherapy trigger programmed cell death in cancer cells, defective cell death programs can lead to treatment resistance and tumor immune escape. Therefore, evasion of programmed cell death may provide one possible explanation as to why cancer immunotherapy has so far only shown modest clinical benefits for children with cancer. A better understanding of the molecular mechanisms that regulate sensitivity and resistance to programmed cell death is expected to open new perspectives for the development of novel experimental treatment strategies to enhance the efficacy of cancer immunotherapy in the future.

In: Frontiers in oncology, Lausanne : Frontiers Media, 2011-, Band 3, Heft 29 (2013), 2234-943X

In: volume:3

In: year:2013

In: number:29

In: extent:5

Sprache: Englisch

DOI: 10.3389/fonc.2013.00029

URN: urn:nbn:de:hebis:30:3-274105

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Die antiproliferative Wirkung von Alkylanzien, Platinderivaten, Antimetaboliten und Zilascorb auf sechs humane neuroektodermale Zellinien in vitro (1995)

Fulda, Simone [Verfasser] 1968-

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UID:

(DE-602)b3kat_BV010433939

Umfang: 140 S. , Ill., graph. Darst.

Anmerkung: Köln, Univ., Diss., 1995

Sprache: Deutsch

Schlagwort(e): Hochschulschrift

URL: Inhaltsverzeichnis

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Fernleihwunsch

HU Berlin

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Möglichkeiten und Grenzen Individualisierter Medizin in der Onkologie (2014)

Fulda, Simone 1968-

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UID:

(DE-627)1479525081

ISBN: 3642450105

In: Rechtsfragen der Personalisierten Medizin, Berlin : Springer, 2014, (2014), Seite 1-3, 3642450105

In: 9783642450105

In: year:2014

In: pages:1-3

Sprache: Deutsch

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