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  • 1
    Book
    Book
    Heidelberg [u.a.] :Springer,
    UID:
    almahu_BV040943032
    Format: VIII, 346 S. : , Ill., graph. Darst.
    ISBN: 978-3-642-27339-1 , 978-3-642-42936-1
    Series Statement: Current topics in microbiology and immunology 369
    Additional Edition: Erscheint auch als Online-Ausgabe ISBN 978-3-642-27340-7
    Language: English
    Subjects: Medicine
    RVK:
    Keywords: Hepatitis-C-Virus ; Aufsatzsammlung
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Online Resource
    Online Resource
    Berlin, Heidelberg : Springer Berlin Heidelberg
    UID:
    gbv_1647672643
    Format: Online-Ressource (digital)
    ISBN: 9783540790860
    Series Statement: Handbook of Experimental Pharmacology 189
    Additional Edition: ISBN 9783540790853
    Additional Edition: Erscheint auch als Druck-Ausgabe Handbook of experimental pharmacology ; 189: Antiviral strategies Berlin : Springer, 2009 ISBN 9783540790853
    Additional Edition: ISBN 3540790853
    Language: English
    Subjects: Chemistry/Pharmacy
    RVK:
    Keywords: Virostatikum ; Virostatikum ; Aufsatzsammlung
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
    Author information: Bartenschlager, Ralf 1958-
    Library Location Call Number Volume/Issue/Year Availability
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  • 3
    UID:
    gbv_1652255508
    Format: Online-Ressource (VIII, 346 p. 34 illus., 20 illus. in color, digital)
    ISBN: 9783642273407
    Series Statement: Current Topics in Microbiology and Immunology 369
    Content: Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted
    Content: Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted
    Note: Description based upon print version of record , The Origin of Hepatitis C Virus -- Cell Culture Systems for Hepatitis C Virus -- Animal Models for Hepatitis C -- Hepatitis C Virus Entry -- Hepatitis C Virus Proteins: From Structure to Function -- Hepatitis C Virus RNA Translation -- Hepatitis C Virus RNA Replication -- Virion Assembly and Release -- Innate Immune Responses to Hepatitis C Virus -- Adaptive Immune Responses in Hepatitis C Virus Infection -- Liver Injury and Disease Pathogenesis in Chronic Hepatitis C -- Hepatitis C Virus-Specific Directly Acting Antiviral Drugs -- Treatment of Chronic Hepatitis C: Current and Future.
    Additional Edition: ISBN 9783642273391
    Additional Edition: Erscheint auch als Druck-Ausgabe Hepatitis C virus Berlin : Springer, 2013 ISBN 9783642273391
    Language: English
    Subjects: Medicine
    RVK:
    Keywords: Hepatitis-C-Virus ; Aufsatzsammlung
    URL: Volltext  (lizenzpflichtig)
    Author information: Bartenschlager, Ralf 1958-
    Library Location Call Number Volume/Issue/Year Availability
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  • 4
    Online Resource
    Online Resource
    Berlin, Heidelberg :Springer Berlin Heidelberg :
    UID:
    almahu_9949419332502882
    Format: XI, 379 p. 52 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2009.
    ISBN: 9783540790860
    Series Statement: Handbook of Experimental Pharmacology, 189
    Content: A crucial issue for antiviral therapy is the fact that all antiviral substances rapidly select for resistance; thus, monitoring and overcoming resistance has become a most important clinical paradigm of antiviral therapy. This calls for cautious use of antiviral drugs and implementation of combination therapies. In parallel, efforts in drug discovery have to be continued to develop compounds with novel mode-of-action and activity against resistant strains. This book reviews the current status of antiviral therapy, from the roads to development of new compounds to their clinical use and cost effectiveness. Individual chapters address in more detail all available drug classes and outline new approaches currently under development.
    Note: Antiviral Strategies -- Approaches for the Development of Antiviral Compounds: The Case of Hepatitis C Virus -- Antiviral Agents Acting as DNA or RNA Chain Terminators -- Viral Protease Inhibitors -- Anti-Influenza Drugs: The Development of Sialidase Inhibitors -- Other Inhibitors of Viral Enzymes and Functions -- Inhibitors of Viral Entry -- Interferons and Their Use in Persistent Viral Infections -- Nucleic Acids-Based Therapeutics in the Battle Against Pathogenic Viruses -- Antiviral Gene Therapy -- Antiviral Resistance and Impact on Viral Replication Capacity: Evolution of Viruses Under Antiviral Pressure Occurs in Three Phases -- Antiviral Combination Therapy for Treatment of Chronic Hepatitis B, Hepatitis C, and Human Immunodeficiency Virus Infection -- Socio-Economic Impact of Antiviral Intervention.
    In: Springer Nature eBook
    Additional Edition: Printed edition: ISBN 9783540871842
    Additional Edition: Printed edition: ISBN 9783642097959
    Additional Edition: Printed edition: ISBN 9783540790853
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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