UID:
edocfu_9958353932402883
Format:
1 online resource(xiv,226p.) :
,
illustrations.
Edition:
Electronic reproduction. Berlin/Boston : De Gruyter. Mode of access: World Wide Web.
Edition:
System requirements: Web browser.
Edition:
Access may be restricted to users at subscribing institutions.
ISBN:
9783110270723
Series Statement:
Dahlem Workshop Reports
Content:
Optogenetics combines genetic engineering with optics to observe and control the function of cells using light, with clinical implications for restoration of vision and treatment of neurological diseases. As a new discipline much of the basic science and methods are currently under investigation and active development, thus there is a strong need for introductory literature in this field. This graduate level textbook provides an overview of the field of optogenetics in 5 concise chapters: Optogenetic tools, Applications in cellular systems, Mapping neuronal networks, Clinical applications and Restoration of vision and hearing. The concept and content was developed with top international researchers and students at a prestigious Dahlem Conference workshop.
Note:
Frontmatter --
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Content --
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Introduction --
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1 The biophysics and engineering of signaling photoreceptors /
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2 Current challenges in optogenetics /
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3 Challenges and opportunities for optochemical genetics /
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4 Optogenetic imaging of neural circuit dynamics using voltage-sensitive fluorescent proteins: potential, challenges and perspectives /
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5 Why optogenetic "control" is not (yet) control /
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6 Optogenetic actuation, inhibition, modulation and readout for neuronal networks generating behavior in the nematode Caenorhabditis elegans /
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7 Putting genetics into optogenetics: knocking out proteins with light /
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8 Optogenetic approaches in behavioral neuroscience /
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9 Combining genetic targeting and optical stimulation for circuit dissection in the zebrafish nervous system /
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10 Optogenetic analysis of mammalian neural circuits /
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11 Optogenetics to benefit human health: opportunities and challenges /
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12 Optogenetic tools for controlling neural activity: molecules and hardware /
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13 In vivo application of optogenetics in rodents /
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14 Potential of optogenetics in deep brain stimulation /
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15 Optogenetic approaches for vision restoration /
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16 Restoration of vision – the various approaches /
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17 Optogenetic approaches to cochlear prosthetics for hearing restoration /
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18 History in the making: the ethics of optogenetics /
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19 Optogenetics as a new therapeutic tool in medicine? A view from the principles of biomedical ethics /
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Appendix --
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Index.
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In English.
Language:
English
DOI:
10.1515/9783110270723
URL:
https://doi.org/10.1515/9783110270723
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