Kooperativer Bibliotheksverbund

UID:

Format: 1 Online-Ressource (XV, 304 p. 34 illus., 32 illus. in color)

Edition: 1st ed. 2024

ISBN: 9783031629839

Series Statement: Advances in Neurobiology 38

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-031-62982-2

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-031-62984-6

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-031-62985-3

Language: English

DOI: 10.1007/978-3-031-62983-9

URL: Volltext  (URL des Erstveröffentlichers)

URL: lizenzpflichtig

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Format: 1 online resource (306 pages)

Edition: First edition.

ISBN: 9783031629839

Series Statement: Advances in Neurobiology Series ; Volume 38

Note: Intro -- Preface -- Acknowledgements -- Contents -- Contributors -- About the Editors -- Part I: Introduction -- Engrams to Remember: A Conversation Between Johannes Gräff and Steve Ramirez -- Part II: Engram Cells and Their Mnemonic Role Across Different Brain Structures -- Engrams: From Behavior to Brain-Wide Networks -- Episodic Memory and the Hippocampus -- A Brief History of Memory Engrams -- Expanding the Engram's Behavioral Repertoire -- Hippocampal Engrams Engage Brain-Wide Networks -- Conclusions -- References -- Memory Storage in Distributed Engram Cell Ensembles -- Mapping Engram Cells Across the Brain -- Thalamic Contributions to Memory -- Reactivation of Engram Cells During Recall -- Perspectives for Future Engram Research -- References -- Hippocampal Engrams and Contextual Memory -- Introduction -- Context Processing and the Hippocampus -- Hippocampal Engrams as the Substrate of Context Memory -- Methods for Engram Capture and Manipulations -- Capturing Hippocampal Engrams During Contextual Learning -- Capturing Hippocampal Engrams During Memory Retrieval -- Conclusion -- References -- The Role of Prefrontal Ensembles in Memory Across Time: Time-Dependent Transformations of Prefrontal Memory Ensembles -- Introduction -- Prefrontal Subdivisions and Fear Memory -- mPFC Engrams-Cellular and Molecular Plasticity Across Time -- mPFC Engrams-Circuit Mechanisms Across Time -- mPFC Engrams and Ensembles-Broadening Theories and Definitions -- References -- Part III: Insights into Intra-Engram Functioning -- All IEGs Are Not Created Equal-Molecular Sorting Within the Memory Engram -- Introduction -- Fos: The Prototypical, Best-Known, and Most Widely Used IEG -- Labeling of the Fos Engram Ensemble -- Roles of Fos Ensemble Neurons in Memory Expression -- Synaptic Plasticity on the Fos Ensemble Neurons. , Npas4: A Neuronal-Specific and Activity Selective IEG -- Labeling of the Npas4 Engram Ensemble -- Role of Npas4 Ensemble Neurons in Learning and Memory -- Synaptic Plasticity on Npas4 Ensemble Neurons -- Arc: A Non-transcription Factor IEG with Complex Functions -- Labeling the Arc Engram Ensemble -- Roles of the Arc Ensemble in the Memory Engram -- Synaptic Plasticity on the Arc Ensemble -- Egr1: An Old-Timer IEG That Has Not Received as Much Attention -- Labeling the Egr1 Engram Ensemble -- Roles of Egr1 Ensemble Neurons in Memory Expression -- Discussion -- Signaling Pathways for IEG Transcription Activation -- Post-transcriptional Regulation -- Intrinsic and Extrinsic Factors -- Closing Remarks -- References -- Unveiling Transcriptional and Epigenetic Mechanisms Within Engram Cells: Insights into Memory Formation and Stability -- Introduction -- Genomic Mechanisms in Memory Allocation -- CREB-Driven Mechanisms in Memory Allocation -- Epigenetic Mechanisms That Modulate Memory Allocation -- Genomic Mechanisms Within Engram Cells During Memory Consolidation -- Activity-Driven Transcription During Memory Formation -- Transcriptional Response in Engram Cells During Memory Consolidation -- Epigenetic Mechanisms Within Memory Engrams -- Genomic Mechanisms of Engrams During Memory Recall -- Update, Removal and Fading of Memory Traces -- Conclusions -- References -- Synaptic Engram -- Overview -- Hebbian Plasticity -- History of Synaptic Engrams -- Study of Synaptic Engrams -- Conclusion -- References -- Part IV: Beyond Associative Learning: Engrams for Other Memory Processes -- Engrams of Fear Memory Attenuation -- Introduction -- The Fear Memory Trace Is Updated by Extinction Learning -- The Fear Memory Trace Is Suppressed by Extinction Learning -- The Expression of the Fear Memory Trace Is Constrained by Reconsolidation Blockers -- Discussion. , Glossary -- References -- Adult Neurogenesis, Context Encoding, and Pattern Separation: A Pathway for Treating Overgeneralization -- Adult Hippocampal Neurogenesis in the Dentate Gyrus -- Methodological Considerations for Examining the Role of AHN in Memory -- AHN and Contextual Encoding -- AHN and Pattern Separation -- Clinical and Translational Implications -- References -- What Can Hippocampal Engrams Tell Us About Encoding Spatial Navigation? -- Hippocampus and Memory -- Hippocampus Function and History -- History -- Human Studies -- Long-Term Potentiation -- Engrams and Memory -- Hippocampus and Space -- Place Cells -- History and Characteristics of Place Cells -- Physiology of Place Cells -- Stability of Place Cells -- Navigational Strategies -- Engrams and Navigation -- Immediate Early Genes and Navigation -- Engrams and Navigation -- Conclusions -- References -- Understanding Others' Distress Through Past Experiences: The Role of Memory Engram Cells in Observational Fear -- Introduction -- Neural Circuit Mechanisms of Naive OF -- Neural Circuit Mechanisms of Experience-Dependent OF -- A BLA Fear Memory Engram Mechanism for Exp OF -- vHPC Neurons Access BLA Fear Memory Engram Cells to Trigger Exp OF -- Future Directions -- Conclusion -- References -- Part V: Beyond the Neurobiology of Engrams -- A Computational Framework for Memory Engrams -- Associations and Auto-associations in Memory -- Concept Cells -- Coding for Single Concepts -- Association Between Concepts -- Fundamental Questions -- Neuronal Assemblies as Memory Engrams -- Modeling Memory Networks -- Attractor Networks -- Bio-plausibility of Attractor Memory Networks -- Generalized Hopfield Model -- Theory, Computer Simulations, and Low-Dimensional Factors -- How Can Shared Concept Cells Encode Associations? -- Association Chains -- Conclusions. , Other Applications of Hopfield and Generalized Hopfield Networks -- Other Areas: ITC -- Nonbinary Engrams -- Spiking Hebbian Networks -- Bibliography -- Engram Studies: A Call for Historical, Philosophical, and Sociological Approaches -- Introduction -- The Foundations of Engram Theory: Philosophical Issues -- A Gap in the Historiography of the Engram -- Representing and Intervening: Social Studies of Engram Manipulation -- Conclusion -- References -- If Engrams Are the Answer, What Is the Question? -- Introduction -- Levels, Questions, and Explanations -- If Engram Is the Answer, What Was the Question? -- Dividing Explanations Based on Levels of Biological Organization -- Dividing Explanations Based on Question-Type -- Dividing Explanations Based on Subdividing the Problem -- What Flavor of Model Are We Using in Engram Biology? -- Current Engram Theory Is Modular and Compositional -- Relational and Essentialist Conceptions of "the Engram" -- Ensembles Are Conflated with Pieces of Information -- Essentialist and Relational Views of Ensemble and Complex Function -- Cutting Across the Levels -- If Engrams Are Vehicles, What Are They Vehicles of? -- Representations Versus Neural Representations -- Engrams-as-Content -- Engrams-as-Vehicles -- Engrams-as-Ensembles -- A Vehicle-Information Distinction -- Information and Coding -- The Necessity of a Theory of Information -- Classical Information Theory and Coding Metaphors -- Information Is Relational and Momentary -- What's Next? -- Arbitrariness -- Coding Strength and Universality -- Reading -- Discussion -- References -- Index.

Additional Edition: ISBN 9783031629822

Language: English

UID:

Format: XV, 304 p. 34 illus., 32 illus. in color. , online resource.

Edition: 1st ed. 2024.

ISBN: 9783031629839

Series Statement: Advances in Neurobiology, 38

Content: This is the first book to extensively explore the current state-of-the-art and promise of engram cells, the closest physical approximation of the memory trace to date. Converging evidence suggests that memories are stored, at least in part, as specific populations of engram cells. In this book, the leading experts in engram biology share their continuously refined insights on how engram cells contribute to information encoding and storage, across diverse brain regions and behavioral modalities. "Engrams: A Window into the Memory Trace" is broad in scope and spans molecular, cellular, circuit, computational as well as societal-philosophical aspects of memory engrams. Particular emphasis is placed on their emerging translational value for memory dysfunctions in age and stress-related disorders. .

Note: Section I: Introduction -- Engrams to remember - A conversation between Johannes and Steve -- Section II: Engram cells and their mnemonic role across different brain structures -- Engrams: From behavior to brain-wide networks -- Memory storage in distributed engram cell ensembles -- Hippocampal engrams and contextual memory -- The role of prefrontal ensembles in memory across time - Time-dependent transformations of prefrontal memory ensembles -- Section III: Insights into intra-engram functioning -- All IEGs are not created equal - Molecular sorting within the memory engram -- Unveiling transcriptional and epigenetic mechanisms within engram cells: Insights into memory formation and stability -- The synaptic engram -- Section IV: Beyond associative learning: Engrams for other memory processes -- Engrams of fear memory attenuation -- Adult neurogenesis, context encoding, and pattern separation: A pathway for treating overgeneralization -- What can hippocampal engrams tell us about encoding spatial navigation? -- Understanding others' distress through past experiences: The role of memory engram cells in observational fear -- Section V: Beyond the neurobiology of engrams -- A computational framework for memory engrams -- Engram studies: A call for historical, philosophical and sociological approaches -- If engrams are the answer, what is the question?.

In: Springer Nature eBook

Additional Edition: Printed edition: ISBN 9783031629822

Additional Edition: Printed edition: ISBN 9783031629846

Additional Edition: Printed edition: ISBN 9783031629853

Language: English

DOI: 10.1007/978-3-031-62983-9

URL: https://doi.org/10.1007/978-3-031-62983-9