Format:
Online-Ressource
ISSN:
2366-3987
Content:
Abstract: Tolerogenic dendritic cells (tDCs) induces regulatory T cell (Treg) differentiation and promotes immune tolerance. However, the effective generation of tDCs in vivo to treat autoimmune diseases remains a significant challenge. In this study, the potential of 1α, 25‐Dihydroxyvitamin D3 (VD3) is explored, which has been shown to promote tDCs differentiation in vitro, to induce tDCs in a mouse model of experimental autoimmune encephalomyelitis (EAE). To overcome the poor solubility of VD3 and induce autoantigen‐specific Tregs, a PLGA‐PEG‐based nano‐drug delivery system is prepared to co‐deliver VD3 and myelin‐oligodendrocyte glycoprotein (MOG) peptides. It is found that intradermal (i.d.) injection of NP/VD3/MOG significantly enhanced the level of antigen‐specific Tregs in vivo. Furthermore, NP/VD3/MOG remarkedly delayed the onset, reduced the severity, and promoted the recovery of EAE mice. This study provides an effective strategy for the treatment of autoimmune diseases.
In:
day:18
In:
month:05
In:
year:2023
In:
extent:10
In:
Advanced therapeutics, Weinheim : Wiley-VCH Verlag, [2018]-, (18.05.2023) (gesamt 10), 2366-3987
Language:
English
DOI:
10.1002/adtp.202200274
URN:
urn:nbn:de:101:1-2023051915032601699535
URL:
https://doi.org/10.1002/adtp.202200274
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023051915032601699535
URL:
https://d-nb.info/1289877084/34
URL:
https://doi.org/10.1002/adtp.202200274
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