Format:
Online-Ressource
ISSN:
1612-1880
Content:
Abstract: The crystal structure of ‘2,2′,4‐trihydroxybenzophenone’ (=(2,4‐dihydroxyphenyl)(2‐hydroxyphenyl) methanone; 1) was determined, and its molecular structure, along with intra‐ and intermolecular H‐bonds, was analyzed. The anti‐inflammatory potential of 1, evaluated by means of the rat‐paw‐edema assay, with carrageenan as inflammation stimulus, was found to be similar high as that of indomethacin. In contrast, benzophenone proper (2) was hardly active in this assay. Our results indicate that these anti‐inflammatory effects are related to the action of kinins and prostaglandins. The radical‐scavenging properties of 1 towards DPPH were found to be similar as those of typical phenolics, but somewhat lower than that of ascorbic acid. The structure–activity relationship (SAR) of 1 is discussed.
In:
volume:4
In:
number:3
In:
year:2007
In:
pages:488-499
In:
extent:12
In:
Chemistry & biodiversity, Zürich : Wiley-VHCA, [2004]-, 4, Heft 3 (2007), 488-499 (gesamt 12), 1612-1880
Language:
English
DOI:
10.1002/cbdv.200790041
URN:
urn:nbn:de:101:1-2023072105513498571445
URL:
https://doi.org/10.1002/cbdv.200790041
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023072105513498571445
URL:
https://d-nb.info/1296819442/34
URL:
https://doi.org/10.1002/cbdv.200790041
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