Kooperativer Bibliotheksverbund

UID:

Format: XI, 325 S. , ill. (some col.) , 27 cm

ISBN: 9781627030670 , 1627030670

Series Statement: Methods in molecular biology 933

Content: Includes bibliographical references and index

Note: Non-obese diabetic (NOD) mouse as a model of human type 1 diabetes , Non-obese diabetic (NOD) mouse as a model of human type 1 diabetes , Assessment of diabetic nephropathy in the Akita mouse , BB rat as a model of human type 1 diabetes , Diabetes in mice with monogenic obesity : the db/db mouse and its use in the study of cardiac consequences , Pathophysiology and genetics of obesity and diabetes in the New Zealand obese mouse : a model of the human metabolic syndrome , TALLYHO mouse as a model of human type 2 diabetes , Diet-induced diabetes in the sand rat (Psammomys obesus) , Diabetes in Zucker diabetic fatty rat , GK rat : a prototype for the study of non-overweight type 2 diabetes , Experimentally induced rodent models of type 2 diabetes , Investigation and treatment of type 2 diabetes in nonhuman primates , Determination of beta-cell function : insulin secretion of isolated islets , Determination of beta-cell function : ion channel function in beta cells , Measurement of glucose homeostasis in vivo : glucose and insulin tolerance tests , Measurement of glucose homeostasis in vivo : combination of tracers and clamp techniques , Measurement of insulin sensitivity in skeletal muscle in vitro , Beta-cell autoimmunity , Positional cloning of diabetes genes , Retinal digest preparation : a method to study diabetic retinopathy , Lineage tracing of pancreatic stem cells and beta cell regeneration , Genetic lineage tracing of beta cell neogenesis , Assessment of diabetic nephropathy in the Akita mouse , BB rat as a model of human type 1 diabetes , Diabetes in mice with monogenic obesity : the db/db mouse and its use in the study of cardiac consequences , Pathophysiology and genetics of obesity and diabetes in the New Zealand obese mouse : a model of the human metabolic syndrome , TALLYHO mouse as a model of human type 2 diabetes , Diet-induced diabetes in the sand rat (Psammomys obesus) , Diabetes in Zucker diabetic fatty rat , GK rat : a prototype for the study of non-overweight type 2 diabetes , Experimentally induced rodent models of type 2 diabetes , Investigation and treatment of type 2 diabetes in nonhuman primates , Determination of beta-cell function : insulin secretion of isolated islets , Determination of beta-cell function : ion channel function in beta cells , Measurement of glucose homeostasis in vivo : glucose and insulin tolerance tests , Measurement of glucose homeostasis in vivo : combination of tracers and clamp techniques , Measurement of insulin sensitivity in skeletal muscle in vitro , Beta-cell autoimmunity , Positional cloning of diabetes genes , Retinal digest preparation : a method to study diabetic retinopathy , Lineage tracing of pancreatic stem cells and beta cell regeneration , Genetic lineage tracing of beta cell neogenesis

Additional Edition: 9781627030687

Additional Edition: Online-Ausg. Joost, Hans-Georg Animal Models in Diabetes Research Totowa, NJ : Humana Press, 2012 9781627030687

Language: English

Subjects: Biology

Keywords: Diabetes mellitus ; Tiere ; Modell ; Medizin ; Laboratorium ; Tiermodell

URL: Cover

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Format: Online-Ressource (XI, 325 p. 51 illus., 26 illus. in color, digital)

ISBN: 9781627030687

Series Statement: Methods in Molecular Biology, Methods and Protocols 933

Content: The Non-Obese Diabetic (NOD) Mouse as a Model of Human Type 1 Diabetes -- Assessment of Diabetic Nephropathy in the Akita Mouse -- The BB Rat as a Model of Human Type 1 Diabetes -- Diabetes in Mice with Monogenic Obesity: The db/db Mouse and Its Use in the Study of Cardiac Consequences -- Pathophysiology and Genetics of Obesity and Diabetes in the New Zealand Obese Mouse: A Model of the Human Metabolic Syndrome -- The TALLYHO Mouse as a Model of Human Type 2 Diabetes -- Diet-Induced Diabetes in the Sand Rat (Psammomys obesus) -- Diabetes in Zucker Diabetic Fatty Rat -- The GK Rat: A Prototype for the Study of Non-Overweight Type 2 Diabetes? -- Experimentally Induced Rodent Models of Type 2 Diabetes -- Investigation and Treatment of Type 2 Diabetes in Nonhuman Primates -- Determination of Beta-Cell Function: Insulin Secretion of Isolated Islets -- Determination of Beta-Cell Function: Ion Channel Function in Beta Cells -- Measurement of Glucose Homeostasis In Vivo: Glucose and Insulin Tolerance Tests -- Measurement of Glucose Homeostasis In Vivo: Combination of Tracers and Clamp Techniques -- Measurement of Insulin Sensitivity in Skeletal Muscle In Vitro -- Beta-Cell Autoimmunity -- Positional Cloning of Diabetes Genes -- Retinal Digest Preparation: A Method to Study Diabetic Retinopathy -- Lineage Tracing of Pancreatic Stem Cells and Beta Cell Regeneration -- Genetic Lineage Tracing of Beta Cell Neogenesis.

Content: In recent years, human studies have made enormous contributions towards an understanding of the genetic basis of diabetes mellitus; however, most of the experimentation needed for the invention and testing of novel therapeutic approaches cannot be performed in humans. Thus, there is no alternative to appropriate animal models. In Animal Models in Diabetes Research, expert researchers explore the current status of the most important models and procedures in order to provide a timely resource in experimental diabetology. The first half of the volume serves as a comprehensive overview on our current knowledge of the pathogenesis and pathophysiology of diabetes in animal models through a series of reviews in model strains. The book then continues with vital, established protocols that are employed in the characterization and study of animal models of diabetes. As a volume in the highly successful Methods in Molecular Biology™ series, this work contains the type of detailed description and key implementation advice necessary to achieve successful results. Authoritative and cutting-edge, Animal Models in Diabetes Research delivers essential content that will be an important resource to advance diabetes research in the years to come.

Additional Edition: 9781627030670

Additional Edition: Druckausg. Animal models in diabetes research New York : Humana Press, 2012 9781627030670

Additional Edition: 1627030670

Language: English

Subjects: Biology

Keywords: Diabetes mellitus ; Tiermodell

DOI: 10.1007/978-1-62703-068-7

URL: lizenzpflichtig

URL: Cover

UID:

Format: 12

ISBN: 9781627030687

Content: Retinal digestion is a commonly used method for studying experimental diabetic retinopathy in animal models. The method allows to assess qualitatively and quantitatively the morphology of the retinal vasculature, including characteristics of endothelial cells and pericytes. The digestion method uses the enzyme trypsin and enables the precise evaluation of venolar and arteriolar diameters, endothelial cell and pericyte numbers, and the formation of acellular capillaries.

Note: Gesehen am 13.02.2019

In: Joost, Hans-Georg, Animal Models in Diabetes Research, Totowa, NJ : Humana Press, 2012, (2012), Seite 291-302, 9781627030687

In: year:2012

In: pages:291-302

In: extent:12

Language: English

DOI: 10.1007/978-1-62703-068-7_19

URL: Volltext