Summary
Plasma levels of α-human atrial natriuretic peptide (hANP) were measured in 17 patients with primary hypertension (11 females, 6 males, aged 22–61; blood pressure systolic 154±7 mmHg, diastolic 92±4 mmHg) and in 9 normotensive controls (4 males, 5 females, aged 20–71; blood pressure systolic 117±4 mmHg, diastolic 76±2 mmHg) during unrestricted sodium diet, at the 4th day of a low sodium intake (40–60 mEq/day) and at the 6th day of sodium loading (280–320 mEq/day) both after an overnight rest and after 4 h of upright posture. In the controls, plasma levels of hANP at 8:00 a.m. were lowered from 73±11 to 49±7 pg/ml during low sodium diet and increased to 128±37 pg/ml after high salt intake. Plasma ANP levels were significantly lower after 4 h of upright posture during unrestricted, low and high sodium intake. In the hypertensive group, plasma ANP levels were elevated during unrestricted diet (203±43 pg/ml), during the low sodium period (139±31 pg/ml), and after high sodium intake (267±63 pg/ml) compared to the controls. All levels were lowered by upright posture. The absolute decrease was more pronounced compared to the normotensives, the relative decline was similar in both groups. In the hypertensives, plasma ANP levels significantly correlate with systolic and diastolic blood pressure (r=0.468,r=0.448,P<0.05) and with urinary aldosterone during unrestricted diet (r=0.536,P<0.05). There was an inverse correlation between plasma ANP levels and plasma renin concentration during low and high sodium intake (r=−0.469,r=−0.496,P<0.05).
These studies demonstrate raised circulating plasma ANP levels in patients with essential hypertension. The modulation of ANP by different sodium intake and by upright posture is maintained similar to the changes in plasma ANP in normotensive controls. Raised ANP levels in the hypertensives are correlated with low renin secretion and high aldosterone excretion. High ANP levels, therefore, might indicate sodium retention in essential hypertension.
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Abbreviations
- ANP:
-
atrial natriuretic peptide
References
Anderson OK, Persson B, Aurell M, Granerus G, Wysocky M, Hedner J, Hedner T (1986) Basal and stimulated levels of immunoreactive atrial natriuretic peptide in normotensive and hypertensive man. Hypertension [Suppl] (In press)
Arendt RM, Stangl E, Zähringer J, Liebisch DC, Herz A (1985) Demonstration and characterization of α-human atrial natriuretic factor in human plasma. FEBS-Letters 189:57–61
Beretta-Piccoli C, Davies DL, Boddy K et al. (1982) Relation of arterial blood pressure with body sodium, body potassium and plasma potassium in essential hypertension. Clin Sci 63:257–270
Blaine EH (1985) Emergence of a new cardiovascular control system Atrial natriuretic factor. Clin Exp Theory Practice [A7]:839–850
Espiner EA (1986) Studies on the secretion, metabolism and action of atrial natriuretic hormone in man. Hypertension [Suppl] (In press)
Helber W, Kaufmann W (1973) Radioimmunologische Methode zur Aldosteronbestimmung im Urin. Klin Wochenschr 51:1164
Helber A, Wambach G, Hummerich W, Bönner G, Meurer KA, Kaufmann W (1980) Evidence for a subgroup of essential hypertensives with non-suppressable excretion of aldosterone during sodium loading. Klin Wochenschr 58:439–447
Hirth C, Stasch JP, John A, Kazda S, Morich F, Neuser D, Wohlfeil S (1986) The renal response of acute hypervolemia is caused by atrial natriuretic peptide. J. Cardiovasc Pharmacol 8:268–275
Hummerich W, Krause DK (1978) Improvement of renin determination in human plasma using a commonly available renin-standard in a radioimmunological method. Klin Wochenschr 53:559–569
Lang RE, Thoelken H, Ganten D, Luft FC, Rieskoaho H, Unger Th (1985) Atrial natriuretic factor — a circulating hormone stimulated by volume loading. Nature 314:264–266
Luft FC, Lang RF, Aronoff GR, Rieskoaho H, Rode A, Ganten D, Sterzel RB, Thof H, Unger Th (1985) Atriopeptin III kinetics in normal and nephric rats. Hochdruck 6:15
Maack Th, Morion DN, Camargo MJ, Kleinert HD, Laragh J, Darracott E, Atlas StA (1984) Effects of auriculin on blood pressure, renal function and the renin-aldosterone system in dogs. Am J Med 77:1069–1075
Sagnella GA, Markanden ND, Shore AC, MacGregor GA (1986) Raised circulating levels of atrial natriuretic peptides in essential hypertension. Lancet:179–181
Stasch IP, Kazda S, Hirth C (1985) Prävention von Hypertonie und Einfluß auf die atrialen natriuretischen Peptide durch Langzeitbehandlung mit Nitrendipin bei SHR. Hochdruck 6:69
Sugawara A, Nakao K, Sakamoto M et al. (1985) Plasma concentration of atrial natriuretic peptide in essential hypertension. Lancet:1426–1427
Wambach G, Götz S, Suckau G, Bönner G, Kaufmann W (1986) Acute and chronic sodium loading stimulates atrial natriuretic factor (ANF) in man. Acta Endocrinol 111 [Suppl 274]:165–166
Wambach G, Helber A, Bönner G, Konrads A, Hummerich W, Meurer KA, Kaufmann W (1982) Characterization of a group of essential hypertensives with impaired regulation of aldosterone. Clin Exp Hyper [A4]:1835–1849
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Wambach, G., Götz, S., Suckau, G. et al. Plasma levels of atrial natriuretic peptide are raised in essential hypertension during low and high sodium intake. Klin Wochenschr 65, 232–237 (1987). https://doi.org/10.1007/BF01715853
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DOI: https://doi.org/10.1007/BF01715853