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Chordoid meningiomas can be sub-stratified into prognostically distinct DNA methylation classes and are enriched for heterozygous deletions of chromosomal arm 2p

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Acknowledgements

This work was supported by the Else Kröner-Fresenius Stiftung (2015_A60 and 2107_EKES.24) and the German Cancer Aid (110983, 111670 and 70112956). We thank Laura Dörner and Hai Yen Nguyen for skillful technical assistance.

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Authors and Affiliations

  1. Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany

    Philipp Sievers, Damian Stichel, Daniel Schrimpf, Annekathrin Reinhardt, Annika K. Wefers, David Reuss, Andreas von Deimling & Felix Sahm

  2. Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany

    Philipp Sievers, Damian Stichel, Daniel Schrimpf, Annekathrin Reinhardt, Annika K. Wefers, David Reuss, Andreas von Deimling & Felix Sahm

  3. Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Thomas Hielscher

  4. Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany

    David T. W. Jones, Stefan M. Pfister & Felix Sahm

  5. Pediatric Glioma Research Group, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany

    David T. W. Jones

  6. Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Melanie Bewerunge-Hudler

  7. Department of Neuropathology, Institute of Pathology, Hannover Medical School (MHH), Hannover, Germany

    Christian Hartmann

  8. Institute of Neurology (Edinger Institute), University Hospital and Medical Faculty, Goethe University, Frankfurt, Germany

    Peter Baumgarten & Patrick N. Harter

  9. Department of Neurosurgery, University Hospital and Medical Faculty, Goethe University, Frankfurt, Germany

    Peter Baumgarten

  10. Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland

    Hans-Georg Wirsching & Michael Weller

  11. Department of Pathology, Odense University Hospital, Odense, Denmark

    Bjarne Winther-Kristensen

  12. Department of Clinical Research, University of Southern Denmark, Odense, Denmark

    Bjarne Winther-Kristensen

  13. Department of Neurosurgery, University Hospital Münster, Münster, Germany

    Benjamin Brokinkel

  14. Department of Neurosurgery, University Hospital Saarland, Homburg, Saar, Germany

    Ralf Ketter

  15. Department of Pathology, Clínica Universidad de Navarra, Pamplona, Spain

    Miguel Angel Idoate Gastearena

  16. Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    Katrin Lamszus

  17. Department of Neurosurgery, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany

    Marcel Seiz-Rosenhagen & Daniel Hänggi

  18. Department of Neuropathology, University Magdeburg, Magdeburg, Germany

    Christian Mawrin

  19. German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Frankfurt, Germany

    Patrick N. Harter

  20. Institute of Neuropathology, Heinrich Heine University, Düsseldorf, Germany

    Jörg Felsberg & Guido Reifenberger

  21. German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Düsseldorf, Germany

    Jörg Felsberg & Guido Reifenberger

  22. Division of Experimental Neurosurgery, Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany

    Christel Herold-Mende

  23. Clinical Division of Oncology, Department of Medicine I, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria

    Anna Sophie Berghoff & Matthias Preusser

  24. Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany

    Stefan M. Pfister

  25. Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany

    Stefan M. Pfister

  26. Department of Neurology and Neurooncology Program, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany

    Wolfgang Wick

  27. Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany

    Wolfgang Wick

Authors
  1. Philipp Sievers
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  2. Damian Stichel
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  7. David Reuss
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  8. David T. W. Jones
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  9. Melanie Bewerunge-Hudler
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  10. Christian Hartmann
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  11. Peter Baumgarten
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  13. Bjarne Winther-Kristensen
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  14. Benjamin Brokinkel
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  15. Ralf Ketter
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  16. Miguel Angel Idoate Gastearena
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  17. Katrin Lamszus
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  18. Marcel Seiz-Rosenhagen
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  19. Christian Mawrin
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  20. Patrick N. Harter
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  21. Jörg Felsberg
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  22. Daniel Hänggi
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  23. Christel Herold-Mende
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  24. Anna Sophie Berghoff
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  25. Michael Weller
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  26. Stefan M. Pfister
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  27. Wolfgang Wick
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  28. Guido Reifenberger
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  29. Matthias Preusser
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  30. Andreas von Deimling
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  31. Felix Sahm
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Corresponding author

Correspondence to Felix Sahm.

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Sievers, P., Stichel, D., Hielscher, T. et al. Chordoid meningiomas can be sub-stratified into prognostically distinct DNA methylation classes and are enriched for heterozygous deletions of chromosomal arm 2p. Acta Neuropathol 136, 975–978 (2018). https://doi.org/10.1007/s00401-018-1924-x

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  • DOI: https://doi.org/10.1007/s00401-018-1924-x

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