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Polypoidal choroidal vasculopathy with drusen

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To study the prevalence and clinical features of drusen in eyes with polypoidal choroidal vasculopathy (PCV).

Methods

Retrospectively, we reviewed the records of 98 consecutive patients with PCV (102 eyes). Drusen were examined in the inner macula, which was defined as an area within 1500µm of the center of the fovea. Eyes that had at least one intermediate or large (≥63µm) soft druse within the inner macula were defined as having drusen.

Results

In these 102 eyes with PCV, 23 (23%) showed soft drusen in the inner macula. In such cases, the fellow eyes, those without a PCV lesion, sometimes also showed soft drusen in the inner macula (11 eyes); 34 (33%) of the eyes with PCV had soft drusen in the inner macula of at least one eye. Comparison of the group of eyes with PCV and drusen in one or both eyes with the group with PCV and no drusen in either eye revealed no significant difference in patient characteristics or in ocular manifestations.

Conclusions

Drusen are not an unusual feature of PCV, at least in Japanese patients, and, when present, they appear to have only a minor effect, if any, on the clinical course.

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References

  1. Smiddy WE, Fine SL. Prognosis of patients with bilateral macular drusen. Ophthalmology 1984;91:271–277.

    Article  CAS  PubMed  Google Scholar 

  2. Bressler NM, Silva JC, Bressler SB, Fine SL, Green WR. Clinicopathologic correlation of drusen and retinal pigment epithelial abnormalities in age-related macular degeneration. Retina 1994;14:130–142.

    Article  CAS  PubMed  Google Scholar 

  3. Klein R, Klein BE, Linton KL. Prevalence of age-related maculopathy. The Beaver Dam Eye Study. Ophthalmology 1992;99:933–943.

    Article  CAS  PubMed  Google Scholar 

  4. Mitchell P, Smith W, Attebo K, Wang JJ. Prevalence of age-related maculopathy in Australia. The Blue Mountains Eye Study. Ophthalmology 1995;102:1450–1460.

    Article  CAS  PubMed  Google Scholar 

  5. Yannuzzi LA, Sorenson J, Spaide RF, Lipson B. Idiopathic polypoidal choroidal vasculopathy. Retina 1990;10:1–8.

    Article  CAS  PubMed  Google Scholar 

  6. Kleiner RC, Brucker AJ, Johnston RL. The posterior uveal bleeding syndrome. Retina 1990;10:9–17.

    Article  CAS  PubMed  Google Scholar 

  7. Perkovich BT, Zakov ZN, Berlin LA, Weidenthal D, Avins LR. An update on multiple recurrent serosanguineous retinal pigment epithelial detachments in black women. Retina 1990;10:18–26.

    Article  CAS  PubMed  Google Scholar 

  8. Spaide RF, Sorenson J, Maranan L. Combined photodynamic therapy with verteporfin and intravitreal triamcinolone acetonide for choroidal neovascularization. Ophthalmology 2003;110:1517–1525.

    Article  PubMed  Google Scholar 

  9. Yuzawa M, Mori R, Kawamura A. The origins of polypoidal choroidal vasculopathy. Br J Ophthalmol 2005;89:602–607.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Uyama M, Matsubara T, Fukushima I, et al. Idiopathic polypoidal choroidal vasculopathy in Japanese patients. Arch Ophthalmol 1999;117:1035–1042.

    Article  CAS  PubMed  Google Scholar 

  11. Uyama M, Wada M, Nagai Y, et al. Polypoidal choroidal vasculopathy: natural history. Am J Ophthalmol 2002;133:639–648.

    Article  PubMed  Google Scholar 

  12. Sho K, Takahashi K, Yamada H, et al. Polypoidal choroidal vasculopathy: incidence, demographic features, and clinical characteristics. Arch Ophthalmol 2003;121:1392–1396.

    Article  PubMed  Google Scholar 

  13. Ahuja RM, Stanga PE, Vingerling JR, Reck AC, Bird AC. Polypoidal choroidal vasculopathy in exudative and haemorrhagic pigment epithelial detachments. Br J Ophthalmol 2000;84:479–484.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Fernandes LH, Freund KB, Yannuzzi LA, et al. The nature of focal areas of hyperfluorescence or hot spots imaged with indocyanine green angiography. Retina 2002;22:557–568.

    Article  PubMed  Google Scholar 

  15. Bird AC, Bressler NM, Bressler SB, et al. An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study Group. Surv Ophthalmol 1995;39:367–374.

    Article  CAS  PubMed  Google Scholar 

  16. Ciardella AP, Donsoff IM, Huang SJ, Costa DL, Yannuzzi LA. Polypoidal choroidal vasculopathy. Surv Ophthalmol 2004;49:25–37.

    Article  PubMed  Google Scholar 

  17. Lafaut BA, Aisenbrey S, Van den Broecke C, Bartz-Schmidt KU, Heimann K. Polypoidal choroidal vasculopathy pattern in age-related macular degeneration: a clinicopathologic correlation. Retina 2000;20:650–654.

    CAS  PubMed  Google Scholar 

  18. Okubo A, Sameshima M, Uemura A, Kanda S, Ohba N. Clinicopathological correlation of polypoidal choroidal vasculopathy revealed by ultrastructural study. Br J Ophthalmol 2002;86:1093–1098.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Nakajima M, Yuzawa M, Shimada H, Mori R. Correlation between indocyanine green angiographic findings and histopathology of polypoidal choroidal vasculopathy. Jpn J Ophthalmol 2004;48:249–255.

    Article  PubMed  Google Scholar 

  20. Silva RM, Figueira J, Cachulo ML, et al. Polypoidal choroidal vasculopathy and photodynamic therapy with verteporfin. Graefes Arch Clin Exp Ophthalmol 2005;243:973–979.

    Article  CAS  PubMed  Google Scholar 

  21. Chan WM, Lam DS, Lai TY, et al. Photodynamic therapy with verteporfin for symptomatic polypoidal choroidal vasculopathy: one-year results of a prospective case series. Ophthalmology 2004;111:1576–1584.

    Article  PubMed  Google Scholar 

  22. Lafaut BA, Leys AM, Snyers B, Rasquin F, De Laey JJ. Polypoidal choroidal vasculopathy in Caucasians. Graefes Arch Clin Exp Ophthalmol 2000;238:752–759.

    Article  CAS  PubMed  Google Scholar 

  23. Maruko I, Iida T, Saito M, Nagayama D, Saito K. Clinical characteristics of exudative age-related macular degeneration in Japanese patients. Am J Ophthalmol 2007;144:15–22.

    Article  PubMed  Google Scholar 

  24. Bonnet M, Pingault C, Tapissier J. Gradual disappearance of macular hyalin verrucosities. Arch Ophtalmol (Paris) 1976;36:465–474.

    CAS  Google Scholar 

  25. Wang JJ, Mitchell P, Smith W, Cumming RG. Bilateral involvement by age related maculopathy lesions in a population. Br J Ophthalmol 1998;82:743–747.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Pauleikhoff D, Barondes MJ, Minassian D, Chisholm IH, Bird AC. Drusen as risk factors in age-related macular disease. Am J Ophthalmol 1990;109:38–43.

    Article  CAS  PubMed  Google Scholar 

  27. Barondes M, Pauleikhoff D, Chisholm IC, Minassian D, Bird AC. Bilaterality of drusen. Br J Ophthalmol 1990;74:180–182.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Ladas ID, Rouvas AA, Moschos MM, et al. Polypoidal choroidal vasculopathy and exudative age-related macular degeneration in Greek population. Eye 2004;18:455–459.

    Article  CAS  PubMed  Google Scholar 

  29. Scassellati-Sforzolini B, Mariotti C, Bryan R, et al. Polypoidal choroidal vasculopathy in Italy. Retina 2001;21:121–125.

    Article  CAS  PubMed  Google Scholar 

  30. Oshima Y, Ishibashi T, Murata T, et al. Prevalence of age related maculopathy in a representative Japanese population: the Hisayama study. Br J Ophthalmol 2001;85:1153–1157.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, 606-8507, Japan

    Daisuke Iwama, Akitaka Tsujikawa, Manabu Sasahara, Yasuhiko Hirami, Hiroshi Tamura & Nagahisa Yoshimura

Authors
  1. Daisuke Iwama
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  2. Akitaka Tsujikawa
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  3. Manabu Sasahara
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  4. Yasuhiko Hirami
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  5. Hiroshi Tamura
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  6. Nagahisa Yoshimura
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Corresponding author

Correspondence to Akitaka Tsujikawa.

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Cite this article

Iwama, D., Tsujikawa, A., Sasahara, M. et al. Polypoidal choroidal vasculopathy with drusen. Jpn J Ophthalmol 52, 116–121 (2008). https://doi.org/10.1007/s10384-007-0503-9

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  • DOI: https://doi.org/10.1007/s10384-007-0503-9

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