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Comparison of three rheological models of shear flow behavior studied on blood samples from post-infarction patients

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Abstract

Quantitative analysis of blood viscosity was performed on the basis of mathematical models of non-Newtonian fluid shear flow behavior (Casson, Ree-Eyring and Quemada). A total of 100 blood samples were drawn from clinically stable survivors of myocardial infarction, treated with aspirin or acenocoumarol and controls to these drugs. Whole blood and plasma viscosity were measured at a broad range of shear rates using a rotary-oscillating viscometer Contraves LS40. Numerical analysis of the experimental data was carried out by means of linear (for Casson) and non-linear regression for the remaining models. In the evaluation of the results, both the fit quality and physical interpretation of the models’ parameters were considered. The Quemada model fitted most precisely with the experimental findings and, despite the controversies concerning the relationship between in vivo tissue perfusion and in vitro rheological measurements, seemed to be a valuable method enhancing investigation possibilities of cardiovascular patients. Our results suggest that aspirin does not affect blood rheological properties, while acenocoumarol may slightly alter red cell deformability and rouleaux formation.

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Authors and Affiliations

  1. Rheological Laboratory, Department of Neurology, University of Medical Sciences, Przybyszewskiego 49 Str., 60-355, Poznań, Poland

    Anna Marcinkowska-Gapińska

  2. Institute of Physics, Adam Mickiewicz University, Poznań, Poland

    Jacek Gapinski

  3. Department of Internal Medicine, Municipal Hospital, Poznań, Poland

    Waldemar Elikowski

  4. Department of Biophysics, University of Medical Sciences, Poznań, Poland

    Feliks Jaroszyk & Leszek Kubisz

Authors
  1. Anna Marcinkowska-Gapińska
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  2. Jacek Gapinski
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  3. Waldemar Elikowski
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  4. Feliks Jaroszyk
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  5. Leszek Kubisz
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Correspondence to Anna Marcinkowska-Gapińska.

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Marcinkowska-Gapińska, A., Gapinski, J., Elikowski, W. et al. Comparison of three rheological models of shear flow behavior studied on blood samples from post-infarction patients. Med Bio Eng Comput 45, 837–844 (2007). https://doi.org/10.1007/s11517-007-0236-4

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  • DOI: https://doi.org/10.1007/s11517-007-0236-4

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