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Proteomanalyse des Myelins, der Isolierschicht der Nerven

Molekulare Neurobiologie

  • Wissenschaft · Special: Proteomics
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Abstract

Rapid signal propagation along vertebrate axons is facilitated by their insulation with myelin, a plasma membrane specialization of glial cells. The recent application of proteomic approaches to biochemically purified myelin established that its protein composition is much more complex than previously thought. Bioinformatic integration of the myelin proteome with other systematic datasets such as mRNA abundance profiles of myelinating glial cells provides valuable resources for the molecular dissection of myelin biology and pathology.

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Author information

Authors and Affiliations

  1. Arbeitsgruppe Proteomics, Max-Planck-Institut Für Experimentelle, Medizin, Göttingen, Deutschland

    Olaf Jahn

  2. Institut für Immunologie, Universitätsmedizin der Universität Mainz, Mainz, Deutschland

    Stefan Tenzer

  3. Abteilung Neurogenetik, Max-Planck-Institut Für experimentelle, Medizin, Göttingen, Deutschland

    Hauke B. Werner

  4. Max-Planck-Institut für Experimentelle Medizin, Hermann-Rein-Straße 3, D-37075, Göttingen, Deutschland

    Olaf Jahn

Authors
  1. Olaf Jahn
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  2. Stefan Tenzer
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  3. Hauke B. Werner
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Corresponding author

Correspondence to Olaf Jahn.

Additional information

Olaf Jahn 1992–1997 Biochemiestudium und 2002 Promotion an der Universität Hannover nach Durchführung der Doktorarbeit am Max-Planck-Institut für Experimentelle Medizin in Göttingen. Dort zunächst Postdoc und seit 2004 Leiter der Arbeitsgruppe Proteomics.

Stefan Tenzer 1994–2000 Biochemiestudium und 2004 Promotion an der Universität Tübingen nach Durchführung der Doktorarbeit am Interfakultären Institut für Zellbiologie. Seit 2004 Postdoc am Institut für Immunologie der Universität Mainz, dort seit 2006 Leiter der Core Facility für Massenspektrometrie und Proteinbiochemie des Forschungszentrums Immunologie.

Hauke B. Werner 1990–1996 Biologiestudium und 2001 Promotion an der Universität Heidelberg. 2001–2003 Postdoc an der Yale Universität, New Haven, CT, USA. 2003–2008 Research Fellow und seither Projektgruppenleiter am Max-Planck-Institut für Experimentelle Medizin in Göttingen.

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Jahn, O., Tenzer, S. & Werner, H.B. Proteomanalyse des Myelins, der Isolierschicht der Nerven. Biospektrum 19, 263–265 (2013). https://doi.org/10.1007/s12268-013-0305-1

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  • DOI: https://doi.org/10.1007/s12268-013-0305-1

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