Abstract
Effects of prolonged photoperiod (18 : 6 model) on the mechanisms regulating microcirculation in the skin were studied in experimental animals. Microcirculation was assessed using laser Doppler flowmetry. It was found that exposure to the prolonged photoperiod regime caused deregulation of blood flow in microvessels, diminishing the amplitudes of endothelial, neurogenic, and myogenic oscillations, and decreased tissue perfusion. The observed hemodynamic abnormalities became more pronounced with longer duration of exposure. Decreased perfusion and progressive impairment of the active factors that regulate microcirculation suggest that exposure to prolonged photoperiod has a negative effect on tissue perfusion, which may be a risk factor for development of cardiovascular diseases.
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Funding
This work was performed as part of the project “Development of a mathematical model to assess the rate at which functional changes in the body due to light-induced desynchronosis transform into irreversible morphological changes in the target organs in a simulation experiment” according to the State Assignment to the Razumovsky Saratov State Medical University of the Ministry of Health of the Russian Federation.
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Translated by D. Timchenko
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Zlobina, O.V., Pakhomii, S.S., Smolina, E.V. et al. Effect of Photoperiod Duration on Microcirculation in the Skin as Assessed Experimentally by Laser Doppler Flowmetry. Opt. Spectrosc. 129, 857–860 (2021). https://doi.org/10.1134/S0030400X21060205
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DOI: https://doi.org/10.1134/S0030400X21060205