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Functional magnetic resonance imaging of swine brain during change in thiopental anesthesia into EEG burst-suppression level — A preliminary study

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Abstract

Deepening anesthesia produces well known changes in electroencephalogram (EEG) and evoked potentials, differing in pathological and normal brain. Yet, it is not known how the T2*-weighted signal changes in the healthy brain during deepening anesthesia. We studied the effect of thiopental bolus on functional magnetic resonance imaging (fMRI) in the healthy brain using porcine model. In five pigs (2–3 months, 20–25 kg), the control bolus prior to fMRI resulted in a change into burst-suppression. After the recovery of continuous EEG, fMRI (4 min) was performed with a single bolus of thiopental (11.4-17.1 mg/kg) administered 1 min after the onset of imaging. This was repeated in four of five pigs. Positive (6-8%) or negative (-3 to -8%) signal intensity changes correlated to the thiopental bolus injection were seen in the group average fMRI response. Positive response was 1.6% and negative response 2.3% of the total brain region of interest (ROI) voxels. Responding voxels were distributed more prominently in the thalamic ROI (4.5%) than in the cortical ROI (2.2%). The group average of unthresholded voxel time courses showed that the net effect of thiopental bolus was a small (0.5%) but a clear positive change in the thalamic region, while variance changed in the global level. In conclusion, this study is the first to show that significant signal intensity changes occur in fMRI response during the sudden deepening of thiopental anesthesia. However, these responses are neither anatomically constant nor global in the healthy swine brain.

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Authors and Affiliations

  1. Department of Diagnostic Radiology, University of Oulu, Kajaanintie 50, 90220, Oulu, Finland

    Minna J. MÄkiranta, Jarkko T. Oikarinen & Osmo Tervonen

  2. Department of Physicsl Biophysics, University of Oulu, 90570, Oulu, Finland

    Minna J. MÄkiranta

  3. Oulu Polytechnic, Institute of Technology, Kotkantie 1, 90250, Oulu, Finland

    Jukka P. T. Jauhiainen & Kalervo Suominen

  4. Department of Anesthesiology, Oulu University Hospital, Oulu, Finland

    Seppo Alahuhta

  5. Department of Clinical Neurophysiology, Oulu University Hospital, Kajaanintie 50, 90220, Oulu, Finland

    Minna J. MÄkiranta & Ville JÄntti

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  1. Minna J. MÄkiranta
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  2. Jukka P. T. Jauhiainen
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Correspondence to Minna J. MÄkiranta.

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MÄkiranta, M.J., Jauhiainen, J.P.T., Oikarinen, J.T. et al. Functional magnetic resonance imaging of swine brain during change in thiopental anesthesia into EEG burst-suppression level — A preliminary study. MAGMA 15, 27–35 (2002). https://doi.org/10.1007/BF02693841

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  • DOI: https://doi.org/10.1007/BF02693841

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