Conditional Cooperativity of Toxin - Antitoxin Regulation Can Mediate Bistability between Growth and Dormancy
Figure 1
Heterocomplex formation in a TA system.
(A) Reaction scheme of the heterocomplex formations, implying that the active complex [AT] is constrained by through and
with complex concentrations expressed by eq. (2). (B) Concentration of AT heteromers for a fixed value of
as a function of
with
. Note that it has a peak at
. In the strong binding limit of
with
(
kept constant),
for
is given by
for
and
, where
always has a peak at
. In this limit,
for
. (C) The behavior of
shown in (B) is reflected in the behavior of the repression factor
as a function of
, calculated for fixed
, and dissociation constant for AT-DNA binding
.