Modeling Retinal Degeneration Using Patient-Specific Induced Pluripotent Stem Cells
Figure 1
iPS cells derived from RP patients.
Mutations identified in patients K21 (RP1) (A), K11 and K10 (RP9) (B), P101 (PRPH2) (C), and P59 (RHO) (D). Patient-derived fibroblast cells (E) were reprogrammed into iPS cells (F). The iPS cells expressed SSEA-4 (G) and Nanog (H). A teratoma formation test confirmed iPS cells' ability to generate all three germ layers: endoderm (I), mesoderm (J) and ectoderm (K). Karyotype analysis (I). Scale bars, 50 µm.