Phosphoethanolamine Transferase LptA in Haemophilus ducreyi Modifies Lipid A and Contributes to Human Defensin Resistance In Vitro
Fig 1
Deletion of two putative PEA transferase genes in H. ducreyi increases susceptibility to HBD-3.
(A) 35000HPΔlptA ptdA, (B) 35000HPΔlptA ptdB, and (C) 35000HPΔptdA ptdB were compared with 35000HP for resistance to the β-defensin HBD-3. All three mutants lacking two putative PEA transferase genes were significantly more sensitive than 35000HP to HBD-3, indicated by asterisks (P < 0.05). Data represent average ± standard error of 3–4 independent assays, and statistical significance was determined by Student’s t-test.