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Glycyrrhizin Exerts Antioxidative Effects in H5N1 Influenza A Virus-Infected Cells and Inhibits Virus Replication and Pro-Inflammatory Gene Expression

Figure 2

Influence of glycyrrhizin on H5N1-induced expression of CXCL10, IL6, and IL8 in A549 cells.

Excretion of cytokines by non-infected (Mock) A549 cells or A549 cells infected with different H5N1 strains at different MOIs 24 h post infection determined by ELISA. For each MOI five bars are presented. From the left to the right these bars represent: untreated virus control, glycyrrhizin 25 µg/ml, glycyrrhizin 50 µg/ml, glycyrrhizin 100 µg/ml, glycyrrhizin 200 µg/ml. * P<0.05 relative to non-treated virus control.

Figure 2

doi: https://doi.org/10.1371/journal.pone.0019705.g002