Identification of a BRCA2-Specific Modifier Locus at 6p24 Related to Breast Cancer Risk
Figure 2
Predicted breast cancer risks for BRCA2 mutation carriers by the combined SNP profile distributions.
Based on the known breast cancer susceptibility loci at FGFR2, TOX3, 12p11, 5q11, CDKN2A/B, LSP1, 8q24, ESR1, ZNF365, 3p24, 12q24, 5p12, 11q13 and the newly identified BRCA2 modifier locus at 6p24. The figure shows the risks at the 5th and 95th percentiles of the combined genotyped distribution as well as minimum, maximum and average risks.