The effect of corn trypsin inhibitor, anti-tissue factor pathway inhibitor antibodies and phospholipids on microvesicle-associated thrombin generation in patients with pancreatic cancer and healthy controls
Fig 2
The effect of inhibiting antibodies against tissue factor (TF) on microvesicle (MV)-associated thrombin generation in pooled normal plasma (PNP) with corn trypsin inhibitor (CTI).
The thrombin generation (lag time) of MVs isolated from pancreatic cancer patients plasma (A) or of MVs isolated from plasma obtained from citrated whole blood that had been incubated with Neisseria meningitidis (108/mL) (B). MVs were analyzed with (circles) or without (squares) preincubation with anti-TF abs, in the presence or absence of phospholipids (MP-reagent) and antibodies against TFPI (anti-TFPI abs). The patient sample with the shortest lag time and the most evident TF-dependent thrombin generation across the four conditions is marked in red.