Activation of ChvG-ChvI regulon by cell wall stress confers resistance to β-lactam antibiotics and initiates surface spreading in Agrobacterium tumefaciens
Fig 3
The response to the depletion of PBP1a mimics transcriptional changes associated with host invasion.
A. Correlation scatterplots depicting relationships between the log2fold-change (L2FC) values in the 6-hour PBP1a depletion and transcriptomic data sets taken under simulated virulence-inducing conditions (AS and AB+AS) and under simulated host-invading conditions (ΔexoR). Each point represents a unique transcript. AS, acetosyrinogone; AB, Agrobacterium minimal media; rho, Spearman correlation coefficient. B. Correlation scatterplots comparing L2FC values of transcripts in the ΔexoR microarray to either the 6-hour or 16-hour PBP1a depletion. Each transcript is colored according to its change in L2FC values from 6 hours of PBP1a depletion to 16 hours of depletion. Gray, no change; Blue, transcript has |L2FC| > 2.0 in the 6-hour but not in the 16-hour depletion; Red, |L2FC| > 2.0 in the 16-hour but not in the 6-hour depletion; Purple, |L2FC| > 2.0 in both the 6-hour and 16-hour depletion.