Disease Biomarkers in Cerebrospinal Fluid of Patients with First-Onset Psychosis
Figure 5
Transthyretin Levels in Sera of First-Onset, Drug-Naïve Schizophrenia Patients and Prefrontal Cortex Post-Mortem Tissue from Schizophrenia Patients
The serum samples from the same patients whose CSF protein profiles were measured in Figures 1 and 6 were included in this study. Figure 5A shows serum tranythyretin levels in patients with schizophrenia significantly decreased by ~15% compared to control subjects. Data are shown in mean ± standard deviation, and the asterisk denotes p = 0.0007 (t-test). Figure 5B indicates no correlation between serum transthyretin and CSF SELDI signals from one of the transthyretin isoforms (m/z = 13,741) in the second sample set (for demographics, see Table 2). Similar results were found when comparing with signals from other isoforms in CSF (unpublished data). Figure 5C shows an ~40% decrease of transthyretin expression in prefrontal cortex of five patients with schizophrenia and in five control subjects. For demographic details, see Table 5.