Signal Regulatory Protein α (SIRPα)+ Cells in the Adaptive Response to ESAT-6/CFP-10 Protein of Tuberculous Mycobacteria
Figure 5
CD172a cells infiltrate rESAT-6:CFP-10 injection sites.
Mycobacterium bovis-infected cattle (n = 5) received 400 µg rESAT-6:CFP-10 intradermally and reactions were characterized after 6 days. Injection sites were collected at necropsy, snap frozen, and evaluated by immunohistochemistry for expression of (A) CD172a, (B) CD11c, (C) CD3, and (D) CD14 on cellular surfaces. Few B cells or γδ T cells were detected (data not shown).